Protein Information

Cytoscape View


UniProt AC / UniProt ID P49354 / FNTA_HUMAN
Protein Name Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Gene Name Name: FNTA
Organism Homo sapiens (Human)

PRO ID PR:P49354
DAG View
PRO Name protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (human)
Definition A protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha that is encoded in the genome of human.
Short Label hFNTA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P49354 (FNTA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
S49 Phosphorylation PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
Y92 Phosphorylation PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
T247 Phosphorylation PhosphoSitePlus
T248 Phosphorylation PhosphoSitePlus
Y250 Phosphorylation PhosphoSitePlus
R253 Methylation PhosphoSitePlus
R287 Methylation PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
T350 Phosphorylation PhosphoSitePlus
Y358 Phosphorylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
T369 Phosphorylation PhosphoSitePlus
S373 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
T375 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S373 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R253 H253 Biomuta DOID:363 / uterine cancer [ tcga ]
R287 L287 Biomuta DOID:3571 / liver cancer [ icgc ]
Y358 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T369 I369 Biomuta DOID:11934 / head and neck cancer [ tcga ]
T369 S369 Biomuta DOID:11934 / head and neck cancer [ tcga ]