iPTMnet Report for P49354 (FNTA)
Protein Information
UniProt AC / UniProt ID | P49354 / FNTA_HUMAN |
Protein Name | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
Gene Name | Name: FNTA |
Organism | Homo sapiens (Human) |
PRO ID | PR:P49354 |
PRO Name | protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (human) |
Definition | A protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha that is encoded in the genome of human. |
Short Label | hFNTA |
Category | organism-gene |
P49354 (FNTA) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
A2 | Acetylation | score1 | UniProt | 19413330 | ||
S49 | Phosphorylation | score1 | PhosphoSitePlus | |||
S60 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y92 | Phosphorylation | score1 | PhosphoSitePlus | |||
S93 | Phosphorylation | score1 | PhosphoSitePlus | |||
K142 | Ubiquitination | score1 | PhosphoSitePlus | |||
K198 | Ubiquitination | score1 | PhosphoSitePlus | |||
K228 | Ubiquitination | score1 | PhosphoSitePlus | |||
T247 | Phosphorylation | score1 | PhosphoSitePlus | |||
T248 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y250 | Phosphorylation | score1 | PhosphoSitePlus | |||
R253 | Methylation | score1 | PhosphoSitePlus | |||
R287 | Methylation | score1 | PhosphoSitePlus | |||
K336 | Ubiquitination | score1 | PhosphoSitePlus | |||
K346 | Ubiquitination | score1 | PhosphoSitePlus | |||
T350 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y358 | Phosphorylation | score1 | PhosphoSitePlus | |||
K366 | Ubiquitination | score1 | PhosphoSitePlus | |||
T369 | Phosphorylation | score1 | PhosphoSitePlus | |||
S373 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 20068231 | ||
T375 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
A2 | S2 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
R253 | H253 | Biomuta | DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ] | |
R253 | C253 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
R287 | C287 | Biomuta | DOID:4159 / skin cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] | |
Y358 | * | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
T369 | S369 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
T369 | I369 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] |