iPTMnet Report for P48431 (SOX2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P48431 / SOX2_HUMAN
Protein Name Transcription factor SOX-2
Gene Name Name: SOX2
Organism Homo sapiens (Human)

PRO ID PR:P48431
DAG View
PRO Name transcription factor SOX-2 (human)
Definition A transcription factor SOX-2 that is encoded in the genome of human.
Short Label hSOX2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P48431 (SOX2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S37 Phosphorylation PhosphoSitePlus
K42 Methylation PhosphoSitePlus   UniProt 29358331
K73 Acetylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
T116 Phosphorylation PhosphoSitePlus   RLIMS-P 29401647, 26498353
K117 Methylation PhosphoSitePlus   UniProt 29358331
T118 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P 20945330, 32194860, 25116380
T118 Phosphorylation P31749 (AKT1) neXtProt 20945330
K121 Ubiquitination PhosphoSitePlus
Y125 Phosphorylation PhosphoSitePlus
T126 Phosphorylation PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
S220 Phosphorylation RLIMS-P 27249336
K245 Sumoylation PhosphoSitePlus
S246 O-Glycosylation GlyGen 34819616, 32574038, 35132862, ...35254053, 31281487, 30620550, 22661428
S246 Phosphorylation PhosphoSitePlus
S249 O-Glycosylation GlyGen 34819616, 32574038, 35132862, ...35254053, 31281487, 30620550, 22661428
S249 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P 19664995, 29556337
S250 O-Glycosylation GlyGen 32574038
S250 Phosphorylation HPRD   PhosphoSitePlus 19664995
S251 O-Glycosylation GlyGen 32574038
S251 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 35944584, 19664995, ...29556337, 27249336
T256 O-Glycosylation GlyGen 34819616, 32574038, 35132862, ...35254053, 31281487, 30620550, 22661428
T256 Phosphorylation PhosphoSitePlus
S257 O-Glycosylation GlyGen 32574038
S259 O-Glycosylation GlyGen 32574038
Y277 Phosphorylation PhosphoSitePlus   RLIMS-P 31823521


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q01860 (POU5F1) T235 P48431 (SOX2) decreased_association eFIP 25116380


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S37 N37 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T116 N116 Biomuta DOID:363 / uterine cancer [ icgc ]
T118 M118 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y125 C125 Biomuta DOID:1319 / brain cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
T126 K126 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T126 M126 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T126 A126 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S251 R251 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y277 H277 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]