Protein Information

Cytoscape View


UniProt AC / UniProt ID P48431 / SOX2_HUMAN
Protein Name Transcription factor SOX-2
Gene Name Name: SOX2
Organism Homo sapiens (Human)

PRO ID PR:P48431
DAG View
PRO Name transcription factor SOX-2 (human)
Definition A transcription factor SOX-2 that is encoded in the genome of human.
Short Label hSOX2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P48431 (SOX2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S37 Phosphorylation PhosphoSitePlus
K73 Acetylation PhosphoSitePlus
T118 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   RLIMS-P 20945330, 25116380
Y125 Phosphorylation PhosphoSitePlus
T126 Phosphorylation PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
S220 Phosphorylation RLIMS-P 27249336
K245 Sumoylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
S249 Phosphorylation HPRD   PhosphoSitePlus 19664995
S250 Phosphorylation HPRD   PhosphoSitePlus 19664995
S251 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 27249336, 19664995


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q01860 (POU5F1) T235 P48431 (SOX2) decreased_association eFIP 25116380
Phosphorylation Q01860 (POU5F1) T235 P48431 (SOX2) increased_association eFIP 25116380