iPTMnet Report for P46527 (CDKN1B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P46527 / CDN1B_HUMAN
Protein Name Cyclin-dependent kinase inhibitor 1B
Gene Name Name: CDKN1B
Synonyms:KIP1;
Organism Homo sapiens (Human)

PRO ID PR:P46527
DAG View
PRO Name cyclin-dependent kinase inhibitor 1B (human)
Definition A cyclin-dependent kinase inhibitor 1B that is encoded in the genome of human.
Short Label hCDKN1B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P46527 (CDKN1B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 O-Glycosylation GlyGen   PhosphoSitePlus 27175940
S10 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12482975, 29247167, 19047162, ...25205104, 27279267, 21715331, 30992462, 25483085, 31863533, 14504289, 10831586, 16160006, 23186163, 16780593, 31754404, 25770303, 18285702, 22970236, 18513991, 16618747, 12093740, 12042314, 20851109, 22711815, 20810788, 15735731, 11889117, 23440295, 16842750, 28535625, 11726503, 28762556, 15302935, 21948550, 12700233, 22178131, 12119282, 15010468, 24337067, 28498440, 16326706, 16492801
S10 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus   Signor 10831586, 11726503
S10 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus 16780593, 12042314, 14504289
S10 Phosphorylation Q00534 (CDK6) neXtProt   PhosphoSitePlus   Signor 16160006
S10 Phosphorylation Q00536 (CDK16) PhosphoSitePlus   Signor 25205104
S10 Phosphorylation Q8TAS1 (UHMK1) PhosphoSitePlus   Signor 10831586, 12093740
S10 Phosphorylation Q9H2X6 (HIPK2) neXtProt   PhosphoSitePlus   Signor 21715331
S10 Phosphorylation Q9UQM7 (CAMK2A) PhosphoSitePlus 20851109
S10 Phosphorylation Q9Y463 (DYRK1B) neXtProt 15010468, 22711815
S12 Phosphorylation PhosphoSitePlus
R15 Methylation PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
C29 Methylation IEDB 31844290
K68 Ubiquitination PhosphoSitePlus
K73 Sumoylation PhosphoSitePlus
Y74 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18454177, 18710949, 22276948, ...17254967
Y74 Phosphorylation P07947 (YES1) HPRD   neXtProt   PhosphoSitePlus 17254967
Y74 Phosphorylation P12931 (SRC) HPRD   phospho.ELM   PhosphoSitePlus   Signor 18710949, 22276948, 17254967
K81 Acetylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
S83 Phosphorylation phospho.ELM   PhosphoSitePlus 15034923
S83 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 15034923
Y88 Phosphorylation HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21423214, 16195327, 22276948, ...35597806, 29330290, 33147476, 17908796, 17254966, 17254967
Y88 Phosphorylation O60674 (JAK2) neXtProt 21423214
Y88 Phosphorylation P00519 (ABL1) HPRD   PhosphoSitePlus   Signor 17908796, 17254966, 22276948
Y88 Phosphorylation P07947 (YES1) HPRD   neXtProt   PhosphoSitePlus 17254967
Y88 Phosphorylation P07948 (LYN) HPRD   neXtProt   PhosphoSitePlus   Signor 21423214, 17254966
Y88 Phosphorylation P12931 (SRC) HPRD   phospho.ELM   PhosphoSitePlus   Signor 17254967
Y89 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16195327, 17908796, 21715330, ...17254967
Y89 Phosphorylation P00519 (ABL1) PhosphoSitePlus 17908796, 21715330
Y89 Phosphorylation P07947 (YES1) neXtProt   PhosphoSitePlus 17254967
Y89 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   Signor 17254967
S106 O-Glycosylation GlyGen   PhosphoSitePlus 27175940
S110 O-Glycosylation GlyGen   PhosphoSitePlus 27175940
K134 Ubiquitination PhosphoSitePlus
S140 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P+ 17525332, 27611996
S140 Phosphorylation Q13315 (ATM) RLIMS-P+ 27611996
K153 Ubiquitination PhosphoSitePlus
R154 Methylation PhosphoSitePlus
T157 O-Glycosylation GlyGen   PhosphoSitePlus 27175940
T157 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18285702, 20200561, 18593906, ...15057270, 23707388, 18710949, 16780593, 18570873, 28762556, 30992462, 28701722, 14504289, 20108172, 12244301, 12244302, 12244303, 15579463, 15743786
T157 Phosphorylation O00141 (SGK1) PhosphoSitePlus   Signor 18570873
T157 Phosphorylation P11309 (PIM1) neXtProt   PhosphoSitePlus   Signor 18593906
T157 Phosphorylation P31749 (AKT1) HPRD   neXtProt   PhosphoSitePlus   Signor 18710949, 12244301, 18570873, ...12244302, 12244303, 15579463, 15743786
T157 Phosphorylation P31751 (AKT2) Signor 12244303
T157 Phosphorylation Q14012 (CAMK1) PhosphoSitePlus 23707388
T157 Phosphorylation Q86V86 (PIM3) neXtProt 18593906
T157 Phosphorylation Q9P1W9 (PIM2) neXtProt 18593906
K165 Ubiquitination PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
S178 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor 22067460, 10831586
S178 Phosphorylation P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10831586
S183 Phosphorylation PhosphoSitePlus
T187 Phosphorylation HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 10375532, 16209941, 15011833, ...11726503, 15172637, 14504289, 11641776, 23846431, 10831586, 16160006, 23029392, 23478441, 9192873, 22970236, 15725363, 12042314, 16508017, 21338280, 20200561, 21224344, 16842750, 17254967, 20810788, 17997402, 19556892, 17409098, 15475007, 10323868, 26146988, 10931950, 21948550, 17053782, 12700233, 15611642, 15735731, 29853883, 28498440, 16326706, 17254966, 16492801
T187 Phosphorylation P06493 (CDK1) Signor 10931950
T187 Phosphorylation P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor 10375532, 17409098, 12042314, ...12700233, 11726503, 9192873, 17997402, 17254966
T187 Phosphorylation P27361 (MAPK3) PhosphoSitePlus   Signor 10931950
T187 Phosphorylation P28482 (MAPK1) neXtProt   PhosphoSitePlus 10831586, 10931950
T187 Phosphorylation P31749 (AKT1) neXtProt 14504289
T187 Phosphorylation Q00534 (CDK6) neXtProt   PhosphoSitePlus   Signor 16160006
T187 Phosphorylation Q00535 (CDK5) RLIMS-P+ 20810788
T198 O-Glycosylation GlyGen   PhosphoSitePlus 27175940
T198 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23440295, 12042314, 19047162, ...23707388, 18710949, 18570873, 30992462, 17237771, 14504289, 22970236, 18593906, 17053782, 15280662, 15743786
T198 Phosphorylation O00141 (SGK1) PhosphoSitePlus   Signor 18570873
T198 Phosphorylation P11309 (PIM1) neXtProt   PhosphoSitePlus   Signor 18593906
T198 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 14504289, 12042314, 15743786, ...15280662, 18710949
T198 Phosphorylation P51812 (RPS6KA3) neXtProt 14504289
T198 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus 17237771
T198 Phosphorylation Q14012 (CAMK1) PhosphoSitePlus 23707388
T198 Phosphorylation Q15418 (RPS6KA1) neXtProt 14504289
T198 Phosphorylation Q86V86 (PIM3) neXtProt 18593906
T198 Phosphorylation Q9P1W9 (PIM2) neXtProt 18593906
Site PTM Type PTM Enzyme Score Source PMID
Y88 Phosphorylation PRO 17254966
T157 Phosphorylation PRO 12244301, 15057270
T187 Phosphorylation PRO 17254966


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046682 (hCDKN1B/Phos:4) pT187 PRO
PR:000046683 (hCDKN1B/Phos:2) pY88 PRO
PR:000025750 (hCDKN1B/iso:1/Phos:2) pY88 PRO 17254966
PR:000025752 (hCDKN1B/iso:1/Phos:3) pY88,pT187 PRO 17254966
PR:000036634 (hCDKN1B/iso:1/Phos:1) pT157 PRO 12244301, 15057270


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P46527 (CDKN1B) S10 O14980 (XPO1) unknown eFIP 11889117
Phosphorylation P46527 (CDKN1B) T198 P16949 (STMN1) unknown eFIP 30992462
Phosphorylation P46527 (CDKN1B) S10 O14980 (XPO1) unknown eFIP 27279267
Phosphorylation P46527 (CDKN1B) S10 O14980 (XPO1) unknown eFIP 25770303


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025750 (hCDKN1B/iso:1/Phos:2) Interaction PR:000026741 (cyclin D1:Cdk4 (human)) PRO 17254966
PR:000025750 (hCDKN1B/iso:1/Phos:2) Interaction PR:P24385 (hCCND1) PRO 17254966
PR:000025750 (hCDKN1B/iso:1/Phos:2) Interaction PR:P24864 (hCCNE1) PRO 17254966
PR:000025750 (hCDKN1B/iso:1/Phos:2) Interaction PR:P20248 (hCCNA2) PRO 17254966
PR:000036634 (hCDKN1B/iso:1/Phos:1) decreased Interaction PR:P52294 (hKPNA1) PRO 15057270
PR:000036634 (hCDKN1B/iso:1/Phos:1) Interaction PR:P61981 (hYWHAG) PRO 15057270
PR:000036634 (hCDKN1B/iso:1/Phos:1) Interaction PR:P62258 (hYWHAE) PRO 15057270
PR:000036634 (hCDKN1B/iso:1/Phos:1) Interaction PR:P31946 (hYWHAB) PRO 15057270
PR:000045370 (hCDKN1B/iso:1/UnPhos:2) Interaction PR:P31749 (hAKT1) PRO 12244301
PR:000045370 (hCDKN1B/iso:1/UnPhos:2) Interaction PR:000026741 (cyclin D1:Cdk4 (human)) PRO 17254966


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S2 L2 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S12 N12 Biomuta DOID:1612 / breast cancer [ cosmic ]
C29 F29 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
C29 Y29 Biomuta [ cosmic ]
C29 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K68 * Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
K73 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K73 N73 Biomuta [ cosmic ]
Y74 * Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
K81 R81 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y88 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y88 C88 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
Y89 * Biomuta DOID:3571 / liver cancer [ cosmic ]
Y89 H89 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K134 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S140 R140 Biomuta DOID:1324 / lung cancer [ cosmic ]
R154 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T157 N157 Biomuta DOID:1612 / breast cancer [ cosmic ]
K165 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S178 F178 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S183 F183 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T198 R198 Biomuta DOID:4159 / skin cancer [ cosmic ]
T198 A198 Biomuta DOID:1612 / breast cancer [ cosmic ]