Protein Information

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UniProt AC / UniProt ID P46527 / CDN1B_HUMAN
Protein Name Cyclin-dependent kinase inhibitor 1B
Gene Name Name: CDKN1B
Synonyms:KIP1;
Organism Homo sapiens (Human)

PRO ID PR:P46527
DAG View
PRO Name cyclin-dependent kinase inhibitor 1B (human)
Definition A cyclin-dependent kinase inhibitor 1B that is encoded in the genome of human.
Short Label hCDKN1B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P46527 (CDKN1B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 O-Glycosylation PhosphoSitePlus
S10 Phosphorylation Q9UQM7 (CAMK2A) , Q00534 (CDK6) , Q9H2X6 (HIPK2) , Q8TAS1 (UHMK1) , Q00536 (CDK16) , P31749 (AKT1) , P28482 (MAPK1) , Q9Y463 (DYRK1B) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12482975, 18346358, 19047162, ...26279144, 21715331, 12093740, 25483085, 20810788, 12042314, 14504289, 22014979, 10831586, 16160006, 23186163, 16780593, 25205104, 27279267, 25770303, 12119282, 18285702, 22970236, 26244023, 21067268, 16618747, 15010468, 17047061, 16790529, 18513991, 20851109, 22711815, 24018641, 24170542, 15280662, 18272788, 11889117, 23440295, 16842750, 28535625, 11726503, 28762556, 15302935, 18384876, 21948550, 21216562, 22584582, 22178131, 15735731, 23965337, 24337067, 28498440, 16326706, 16492801
S12 Phosphorylation PhosphoSitePlus
R15 Methylation PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
Y74 Phosphorylation P07947 (YES1) , P12931 (SRC) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18454177, 18710949, 22276948, ...17254967
K81 Acetylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
S83 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   RLIMS-P 15034923
Y88 Phosphorylation O60674 (JAK2) , P12931 (SRC) , P00519 (ABL1) , P07947 (YES1) , P07948 (LYN) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21423214, 16195327, 22276948, ...29330290, 17908796, 17254966, 17254967
Y89 Phosphorylation P12931 (SRC) , P00519 (ABL1) , P07947 (YES1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16195327, 17908796, 21715330, ...17254967
S106 O-Glycosylation PhosphoSitePlus
S110 O-Glycosylation PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
S140 Phosphorylation Q13315 (ATM) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P 17525332, 27611996
K153 Ubiquitination PhosphoSitePlus
R154 Methylation PhosphoSitePlus
T157 O-Glycosylation PhosphoSitePlus
T157 Phosphorylation Q14012 (CAMK1) , P31749 (AKT1) , P31751 (AKT2) , P11309-2 (PIM1) , O00141 (SGK1) , Q86V86 (PIM3) , Q9P1W9 (PIM2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 26298725, 14504289, 20200561, ...16780593, 18285702, 15743786, 16790529, 18710949, 20108172, 23339869, 18570873, 18593906, 15579463, 15280662, 28185194, 15057270, 23707388, 19079342, 28762556, 26701207, 12244301, 12244302, 12244303
K165 Ubiquitination PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
S178 Phosphorylation P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 10831586, 22067460
S183 Phosphorylation PhosphoSitePlus
T187 Phosphorylation Q00534 (CDK6) , P31749 (AKT1) , P28482 (MAPK1) , Q00535 (CDK5) , P27361 (MAPK3) , P24941 (CDK2) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 10375532, 9927425, 15011833, ...26279144, 10931950, 11726503, 17456787, 15172637, 14504289, 24037419, 11641776, 23846431, 10831586, 16160006, 16465393, 23707764, 23029392, 23478441, 10772955, 23769441, 9192873, 18171537, 22970236, 25851349, 22492278, 15725363, 12093740, 12042314, 16508017, 15475007, 11682478, 20200561, 21224344, 10323868, 16492801, 20810788, 17997402, 19556892, 17409098, 16209941, 16051867, 16842750, 26146988, 21338280, 19451650, 21948550, 16326706, 12700233, 15611642, 15735731, 19852587, 28498440, 17053782, 17254966, 17254967
T198 O-Glycosylation PhosphoSitePlus
T198 Phosphorylation P11309-2 (PIM1) , P31749 (AKT1) , Q14012 (CAMK1) , P51812 (RPS6KA3) , Q13131 (PRKAA1) , Q86V86 (PIM3) , Q15418 (RPS6KA1) , O00141 (SGK1) , Q9P1W9 (PIM2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23440295, 12042314, 19047162, ...23707388, 18710949, 18570873, 17237771, 14504289, 22970236, 18593906, 26032166, 17053782, 15280662, 15743786
Site PTM Type PTM Enzyme Score Source PMID
Y88 Phosphorylation PRO 17254966
T157 Phosphorylation PRO 12244301, 15057270
T187 Phosphorylation PRO 17254966


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046682 (hCDKN1B/Phos:4) pT187 PRO
PR:000046683 (hCDKN1B/Phos:2) pY88 PRO
PR:000025750 (hCDKN1B/iso:1/Phos:2) pY88 PRO 17254966
PR:000025752 (hCDKN1B/iso:1/Phos:3) pY88,pT187 PRO 17254966
PR:000036634 (hCDKN1B/iso:1/Phos:1) pT157 PRO 12244301, 15057270


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P46527 (CDKN1B) S10 unknown eFIP 11889117
Phosphorylation P46527 (CDKN1B) S10 O14980 (XPO1) unknown eFIP 11889117
Phosphorylation P46527 (CDKN1B) S10 O14980 (XPO1) unknown eFIP 11889117
Phosphorylation P46527 (CDKN1B) S10 O14980 (XPO1) unknown eFIP 25770303
Phosphorylation P46527 (CDKN1B) S10 O14980 (XPO1) unknown eFIP 27279267
Phosphorylation P46527 (CDKN1B) T157 P01106 (MYC) inhibited_association eFIP 26701207


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025750 (hCDKN1B/iso:1/Phos:2) Interaction PR:P24864 (hCCNE1) PRO 17254966
PR:000025750 (hCDKN1B/iso:1/Phos:2) Interaction PR:P24864 (hCCNE1) PRO 17254966
PR:000025750 (hCDKN1B/iso:1/Phos:2) Interaction PR:000026741 (cyclin D1:Cdk4 (human)) PRO 17254966
PR:000025750 (hCDKN1B/iso:1/Phos:2) Interaction PR:P20248 (hCCNA2) PRO 17254966
PR:000025750 (hCDKN1B/iso:1/Phos:2) Interaction PR:P24385 (hCCND1) PRO 17254966
PR:000025750 (hCDKN1B/iso:1/Phos:2) Interaction PR:000026741 (cyclin D1:Cdk4 (human)) PRO 17254966
PR:000025750 (hCDKN1B/iso:1/Phos:2) Interaction PR:P20248 (hCCNA2) PRO 17254966
PR:000025750 (hCDKN1B/iso:1/Phos:2) Interaction PR:P24385 (hCCND1) PRO 17254966
PR:000025750 (hCDKN1B/iso:1/Phos:2) Interaction PR:P24864 (hCCNE1) PRO 17254966
PR:000025750 (hCDKN1B/iso:1/Phos:2) Interaction PR:000026741 (cyclin D1:Cdk4 (human)) PRO 17254966
PR:000025750 (hCDKN1B/iso:1/Phos:2) Interaction PR:P20248 (hCCNA2) PRO 17254966
PR:000025750 (hCDKN1B/iso:1/Phos:2) Interaction PR:P24385 (hCCND1) PRO 17254966
PR:000036634 (hCDKN1B/iso:1/Phos:1) decreased Interaction PR:P52294 (hKPNA1) PRO 15057270
PR:000036634 (hCDKN1B/iso:1/Phos:1) Interaction PR:P62258 (hYWHAE) PRO 15057270
PR:000036634 (hCDKN1B/iso:1/Phos:1) Interaction PR:P31946 (hYWHAB) PRO 15057270
PR:000036634 (hCDKN1B/iso:1/Phos:1) Interaction PR:P61981 (hYWHAG) PRO 15057270
PR:000036634 (hCDKN1B/iso:1/Phos:1) decreased Interaction PR:P52294 (hKPNA1) PRO 15057270
PR:000036634 (hCDKN1B/iso:1/Phos:1) Interaction PR:P62258 (hYWHAE) PRO 15057270
PR:000036634 (hCDKN1B/iso:1/Phos:1) Interaction PR:P61981 (hYWHAG) PRO 15057270
PR:000036634 (hCDKN1B/iso:1/Phos:1) Interaction PR:P31946 (hYWHAB) PRO 15057270
PR:000036634 (hCDKN1B/iso:1/Phos:1) decreased Interaction PR:P52294 (hKPNA1) PRO 15057270
PR:000036634 (hCDKN1B/iso:1/Phos:1) Interaction PR:P62258 (hYWHAE) PRO 15057270
PR:000036634 (hCDKN1B/iso:1/Phos:1) Interaction PR:P31946 (hYWHAB) PRO 15057270
PR:000036634 (hCDKN1B/iso:1/Phos:1) Interaction PR:P61981 (hYWHAG) PRO 15057270
PR:000045370 (hCDKN1B/iso:1/UnPhos:2) Interaction PR:P31749 (hAKT1) PRO 12244301
PR:000045370 (hCDKN1B/iso:1/UnPhos:2) Interaction PR:000026741 (cyclin D1:Cdk4 (human)) PRO 17254966
PR:000045370 (hCDKN1B/iso:1/UnPhos:2) Interaction PR:P31749 (hAKT1) PRO 12244301
PR:000045370 (hCDKN1B/iso:1/UnPhos:2) Interaction PR:000026741 (cyclin D1:Cdk4 (human)) PRO 17254966
PR:000045370 (hCDKN1B/iso:1/UnPhos:2) Interaction PR:P31749 (hAKT1) PRO 12244301
PR:000045370 (hCDKN1B/iso:1/UnPhos:2) Interaction PR:000026741 (cyclin D1:Cdk4 (human)) PRO 17254966


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 L2 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K68 R68 Biomuta DOID:9256 / colorectal cancer [ tcga ]
Y74 * Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1612 / breast cancer [ cosmic ]
K81 R81 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S178 F178 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S183 F183 Biomuta DOID:1612 / breast cancer [ tcga ]
T198 A198 Biomuta DOID:1612 / breast cancer [ cosmic ]