Protein Information

Cytoscape View


UniProt AC / UniProt ID P45985 / MP2K4_HUMAN
Protein Name Dual specificity mitogen-activated protein kinase kinase 4
Gene Name Name: MAP2K4
Synonyms:JNKK1,MEK4,MKK4,PRKMK4,SEK1,SERK1,SKK1;
Organism Homo sapiens (Human)

PRO ID PR:P45985
DAG View
PRO Name dual specificity mitogen-activated protein kinase kinase 4 (human)
Definition A dual specificity mitogen-activated protein kinase kinase 4 that is encoded in the genome of human.
Short Label hMAP2K4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P45985 (MAP2K4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
S5 Phosphorylation PhosphoSitePlus
S7 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
K42 Methylation PhosphoSitePlus
K45 Methylation PhosphoSitePlus
K54 Methylation PhosphoSitePlus
T56 Phosphorylation PhosphoSitePlus
R58 Methylation PhosphoSitePlus   UniProt 24129315
T78 Phosphorylation PhosphoSitePlus
S80 Phosphorylation P31749 (AKT1) , O00141 (SGK1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 16000309, 22276160, 17568772, ...11707464, 15998799, 25825522, 17276500, 15911620
S83 Phosphorylation RLIMS-P 15911620
S90 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K131 Acetylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
S257 Phosphorylation Q16584 (MAP3K11) , P45985 (MAP2K4) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19369195, 23157661, 26028649, ...10727406, 22539006, 24275569, 23755811, 9003778, 9162092, 15328343
T261 Phosphorylation Q02779 (MAP3K10) , Q16584 (MAP3K11) , Q13233 (MAP3K1) , P45985 (MAP2K4) , Q99683 (MAP3K5) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 26028649, 23157661, 20589745, ...16000309, 9182538, 10727406, 9712898, 11053428, 23755811, 9003778, 8974401, 9162092, 15328343, 15911620
T391 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation HPRD 20068231
S26 Phosphorylation HPRD 19413330, 20068231
S36 Phosphorylation HPRD 20068231
S80 Phosphorylation P31749 (AKT1) HPRD 11707464
S90 Phosphorylation HPRD 18669648
S257 Phosphorylation P45985 (MAP2K4) HPRD 9162092
T261 Phosphorylation P45985 (MAP2K4) HPRD 9162092
T391 Phosphorylation HPRD 20068231
S393 Phosphorylation HPRD 19413330
S394 Phosphorylation HPRD 19413330, 20068231


P45985 (MAP2K4) as PTM Enzyme



Substrate Site Score Source PMID
O15264 (MAPK13) T180 UniProt 9374491
O15264 (MAPK13) Y182 UniProt 9374491
P19793 (RXRA) Y249 phospho.ELM   PhosphoSitePlus   Signor 10938283
P45983 (MAPK8) T183 neXtProt   PhosphoSitePlus   Signor 7839144, 9724739, 23416355, ...11062067
P45983 (MAPK8) Y185 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 7839144, 9724739, 23416355, ...18669648, 16153436, 11062067, 15911620
P45983-3 (MAPK8) T228 PhosphoSitePlus 23416355
P45983-3 (MAPK8) S284 PhosphoSitePlus 23416355
P45983-3 (MAPK8) S377 PhosphoSitePlus 23416355
P45984-1 (MAPK9) Y185 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 15911620, 11062067
P45985-1 (MAP2K4) S257 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 9162092
P45985 (MAP2K4) T261 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 9162092
P53778 (MAPK12) T183 neXtProt 11062067
P53778-1 (MAPK12) Y185 HPRD   neXtProt   phospho.ELM 19413330, 11062067
P53779-3 (MAPK10) T183 HPRD 19651622, 10715136
P53779-3 (MAPK10) Y185 HPRD 19651622, 10715136
P53779-2 (MAPK10) T221 HPRD 19651622, 10715136
P53779 (MAPK10) Y223 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 19651622, 10715136, 11062067, ...15911620
Q15759 (MAPK11) T180 UniProt 15356147
Q15759 (MAPK11) Y182 UniProt 15356147
Q16539 (MAPK14) T180 neXtProt   PhosphoSitePlus   Signor   UniProt 7839144, 18669648, 7535770
Q16539 (MAPK14) Y182 neXtProt   PhosphoSitePlus   UniProt 7839144, 18669648


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048298 (hMAP2K4/Phos:1) pS257,pT261 PRO