iPTMnet Report for P45984 (MAPK9)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P45984 / MK09_HUMAN
Protein Name Mitogen-activated protein kinase 9
Gene Name Name: MAPK9
Synonyms:JNK2,PRKM9,SAPK1A;
Organism Homo sapiens (Human)

PRO ID PR:P45984
DAG View
PRO Name mitogen-activated protein kinase 9 (human)
Definition A mitogen-activated protein kinase 9 that is encoded in the genome of human.
Short Label hMAPK9
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P45984 (MAPK9) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K56 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
S144 Phosphorylation PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
C163 S-Nitrosylation dbSNO 19483679
K166 Ubiquitination PhosphoSitePlus
T178 Phosphorylation PhosphoSitePlus
T183 Phosphorylation P45985 (MAP2K4) , O14733 (MAP2K7) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17761173, 31668396, 17192257, ...30599894, 9890973, 27698876, 15998799, 11062067, 33791043, 19806201, 15755722, 15911620
Y185 Phosphorylation P45985 (MAP2K4) , P07949 (RET) , O14733 (MAP2K7) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16153436, 31668396, 17192257, ...30599894, 18083107, 27698876, 15998799, 11062067, 33791043, 19806201, 22730327, 15755722, 15911620
T188 Phosphorylation PhosphoSitePlus
K250 Acetylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
Y357 Phosphorylation PhosphoSitePlus
N384 N-Glycosylation GlyGen 29741879
T404 Phosphorylation P68400 (CSNK2A1) , O14733 (MAP2K7) phospho.ELM   PhosphoSitePlus   Signor 11062067
S407 Phosphorylation P68400 (CSNK2A1) , O14733 (MAP2K7) phospho.ELM   PhosphoSitePlus   Signor 11062067
Site PTM Type PTM Enzyme Score Source PMID
T183 Phosphorylation O14733 (MAP2K7) HPRD 11062067
Y185 Phosphorylation P07949 (RET) , P45985 (MAP2K4) , O14733 (MAP2K7) HPRD 16153436, 11062067
T404 Phosphorylation O14733 (MAP2K7) HPRD 11062067
S407 Phosphorylation O14733 (MAP2K7) HPRD 11062067
Site PTM Type PTM Enzyme Score Source PMID
T183 Phosphorylation O14733 (MAP2K7) HPRD 11062067
Y185 Phosphorylation P07949 (RET) , P45985 (MAP2K4) , O14733 (MAP2K7) HPRD   PhosphoSitePlus 16153436, 11062067
Site PTM Type PTM Enzyme Score Source PMID
T183 Phosphorylation O14733 (MAP2K7) HPRD 11062067
Y185 Phosphorylation O14733 (MAP2K7) , P45985 (MAP2K4) , P07949 (RET) HPRD 16153436, 11062067
K236 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T183 Phosphorylation O14733 (MAP2K7) HPRD 11062067
Y185 Phosphorylation O14733 (MAP2K7) , P07949 (RET) , P45985 (MAP2K4) HPRD 16153436, 11062067
T404 Phosphorylation O14733 (MAP2K7) HPRD 11062067
S407 Phosphorylation O14733 (MAP2K7) HPRD 11062067


P45984 (MAPK9) as PTM Enzyme



Substrate Site Score Source PMID
O00418 (EEF2K) S396 HPRD 12171600
O43521-2 (BCL2L11) T56 phospho.ELM 12591950
O43521-1 (BCL2L11) S59 HPRD 12818176
O43521 (BCL2L11) S69 HPRD   neXtProt 12818176
O43521-1 (BCL2L11) S77 HPRD 18691976, 12818176
O43602-2 (DCX) T321 neXtProt   PhosphoSitePlus 14765123
O43602-2 (DCX) T331 neXtProt   PhosphoSitePlus 14765123
O43602-2 (DCX) S334 neXtProt   PhosphoSitePlus 14765123
O60239-2 (SH3BP5) S194 HPRD 15158451
O60239-2 (SH3BP5) S264 HPRD 19413330, 18669648, 15158451, ...16964243, 20068231
O60239 (SH3BP5) S351 HPRD   neXtProt 15158451
O60239-1 (SH3BP5) S421 HPRD 19413330, 18669648, 15158451, ...16964243, 20068231
O95140 (MFN2) S27 PhosphoSitePlus   Signor 22748923
P04150 (NR3C1) S226 neXtProt 18337589
P04637 (TP53) S6 Signor 17525747
P04637 (TP53) S20 PhosphoSitePlus   Signor 11896587
P04637 (TP53) S37 neXtProt 9393873
P04637 (TP53) T81 RLIMS-P+ 27147566
P05067-4 (APP) T668 PhosphoSitePlus 14970211
P05067 (APP) T743 neXtProt 14970211
P05412 (JUN) S63 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14617628, 12040039, 7737130, ...9687508, 19118012, 11948398
P05412 (JUN) S73 neXtProt   PhosphoSitePlus   Signor 9687508, 12040039, 7737130
P10636-8 (MAPT) T181 PhosphoSitePlus 12801934
P10636-8 (MAPT) S202 PhosphoSitePlus 12801934
P10636-8 (MAPT) T212 PhosphoSitePlus 16987243
P10636-8 (MAPT) T217 PhosphoSitePlus 16987243
P10636-8 (MAPT) T231 PhosphoSitePlus 12801934
P10636 (MAPT) T498 neXtProt 15228592
P10636 (MAPT) S516 neXtProt 15228592
P10636 (MAPT) S519 neXtProt 15228592
P10636 (MAPT) T529 neXtProt 15228592
P10636 (MAPT) T548 neXtProt 15228592
P10636 (MAPT) S713 neXtProt 15228592
P10636 (MAPT) S721 neXtProt 15228592
P10636 (MAPT) S739 neXtProt 15228592
P15036 (ETS2) T72 neXtProt 11027273
P15336 (ATF2) T69 HPRD   PhosphoSitePlus   Signor 19413330, 18767875, 7535770, ...19651622, 18669648, 12110590, 20068231, 7737130
P15336-1 (ATF2) T71 HPRD   PhosphoSitePlus   Signor 19413330, 18767875, 7535770, ...19651622, 18669648, 12110590, 20068231, 7737130
P15336 (ATF2) S90 PhosphoSitePlus 7737130
P16104 (H2AX) S140 neXtProt   Signor 16818236, 18158901
P16949 (STMN1) S25 neXtProt 20630875
P16949 (STMN1) S38 neXtProt   Signor 20630875
P19419-1 (ELK1) S383 HPRD 8548291, 9130707
P19419-1 (ELK1) S389 HPRD   Signor 8548291, 9130707, 8846788
P19793 (RXRA) S56 neXtProt 10383391
P19793 (RXRA) S70 neXtProt 10383391
P19793 (RXRA) T82 neXtProt 10383391
P19793 (RXRA) S260 neXtProt   PhosphoSitePlus   Signor 16551633, 10383391
P23443 (RPS6KB1) S434 neXtProt 11279232
P29353 (SHC1) S36 neXtProt 11602589
P30307 (CDC25C) S168 neXtProt   PhosphoSitePlus   Signor 12742231, 20220133
P31645 (SLC6A4) T616 PhosphoSitePlus 24450286
P31947 (SFN) S186 Signor 15071501
P35222 (CTNNB1) S191 neXtProt   Signor 18423204
P35222 (CTNNB1) S605 neXtProt   Signor 18423204
P35568 (IRS1) S307 Signor 14579029
P35568 (IRS1) S315 Signor 9335553
P35568 (IRS1) Y612 Signor 14579029
P35568 (IRS1) Y632 Signor 14579029
P40763 (STAT3) S727 neXtProt   PhosphoSitePlus   Signor 18691976, 20871632
P41970 (ELK3) S357 HPRD   neXtProt 11042694
P41970 (ELK3) S363 neXtProt 11042694
P41970 (ELK3) S396 neXtProt 11042694
P41970 (ELK3) S401 neXtProt 11042694
P42224 (STAT1) S727 neXtProt 14963018
P46937 (YAP1) T119 neXtProt 21364637
P46937 (YAP1) S138 neXtProt 21364637
P46937 (YAP1) T154 neXtProt 21364637
P46937 (YAP1) S367 neXtProt 21364637
P49768 (PSEN1) S319 neXtProt   PhosphoSitePlus   Signor 18667537
P49768 (PSEN1) T320 neXtProt   PhosphoSitePlus   Signor 18667537
P50616 (TOB1) S152 neXtProt   PhosphoSitePlus   Signor 12151396
P50616 (TOB1) S154 neXtProt   PhosphoSitePlus   Signor 12050114, 12151396
P50616 (TOB1) S164 neXtProt   PhosphoSitePlus   Signor 12050114, 12151396
P52945 (PDX1) S61 neXtProt   PhosphoSitePlus 12810726
P52945 (PDX1) S66 neXtProt   PhosphoSitePlus 12810726
P54259 (ATN1) S739 Signor 12812981
P55957 (BID) T59 neXtProt   PhosphoSitePlus 25077544
P63104 (YWHAZ) S184 Signor 15071501
P68431 (H3C12) S29 neXtProt 11278789
P84243 (H3-3B) S29 HPRD 11278789, 20068231
P98177 (FOXO4) T451 neXtProt   phospho.ELM   PhosphoSitePlus 15538382
P98177 (FOXO4) T455 neXtProt   phospho.ELM   PhosphoSitePlus 15538382
Q06481 (APLP2) T736 neXtProt   PhosphoSitePlus 14970211
Q07817 (BCL2L1) T47 neXtProt   PhosphoSitePlus 10617621
Q07817 (BCL2L1) S62 PhosphoSitePlus 22617334
Q07817 (BCL2L1) T115 neXtProt   PhosphoSitePlus 10617621
Q12968 (NFATC3) S163 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9374467
Q12968 (NFATC3) S165 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 9374467
Q14653 (IRF3) S173 neXtProt 19153595
Q14934 (NFATC4) S213 neXtProt   PhosphoSitePlus 17875713
Q14934 (NFATC4) S217 neXtProt   PhosphoSitePlus 17875713
Q5JR12 (PPM1J) S93 Signor 18553930
Q8IW41 (MAPKAPK5) T182 phospho.ELM   PhosphoSitePlus 9628874
Q8WYK2 (JDP2) T148 HPRD   neXtProt   PhosphoSitePlus 12225289, 11602244
Q9BQQ3 (GORASP1) S274 PhosphoSitePlus 25948586
Q9NYV6 (RRN3) T200 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 15805466
Q9UIG0 (BAZ1B) S158 PhosphoSitePlus   Signor 19776015
Q9UPT6 (MAPK8IP3) T265 neXtProt   Signor 15767678, 10523642
Q9UPT6 (MAPK8IP3) T275 neXtProt   Signor 15767678, 10523642
Q9UPT6 (MAPK8IP3) T286 neXtProt   Signor 15767678, 10523642
Q9UQF2 (MAPK8IP1) T103 phospho.ELM   PhosphoSitePlus   Signor 12756254, 15911620


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048328 (hMAPK9/Phos:1) pT183,pY185 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K56 N56 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc, cosmic, icgc, cosmic, icgc, cosmic, icgc ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
S144 * Biomuta DOID:4159 / skin cancer [ cosmic ]
T183 A183 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K250 N250 Biomuta DOID:363 / uterine cancer [ icgc ]
K251 T251 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K300 E300 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S311 F311 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T404 M404 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S407 * Biomuta DOID:1612 / breast cancer [ cosmic ]