iPTMnet Report for P43681 (CHRNA4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P43681 / ACHA4_HUMAN
Protein Name Neuronal acetylcholine receptor subunit alpha-4 precursor
Gene Name Name: CHRNA4
Synonyms:NACRA4;
Organism Homo sapiens (Human)

PRO ID PR:P43681
DAG View
PRO Name neuronal acetylcholine receptor subunit alpha-4 (human)
Definition A neuronal acetylcholine receptor subunit alpha-4 that is encoded in the genome of human.
Short Label hCHRNA4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P43681 (CHRNA4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R10 Methylation PhosphoSitePlus
R25 Methylation PhosphoSitePlus
R33 Methylation PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
S362 Phosphorylation neXtProt   PhosphoSitePlus 12124445
S380 Phosphorylation IEDB 35494241
S467 Phosphorylation neXtProt   PhosphoSitePlus 12124445
S488 Phosphorylation PhosphoSitePlus
S538 Phosphorylation PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus
S543 Phosphorylation PhosphoSitePlus
T545 Phosphorylation PhosphoSitePlus
S550 Phosphorylation PhosphoSitePlus
S561 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R33 W33 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R33 Q33 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R33 L33 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S196 R196 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S362 P362 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S539 W539 Biomuta DOID:1324 / lung cancer [ cosmic ]
S539 L539 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T545 M545 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
T545 R545 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S561 P561 Biomuta DOID:1324 / lung cancer [ cosmic ]
S561 L561 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]