iPTMnet Report for P43681 (CHRNA4)
Protein Information
UniProt AC / UniProt ID | P43681 / ACHA4_HUMAN |
Protein Name | Neuronal acetylcholine receptor subunit alpha-4 precursor |
Gene Name | Name: CHRNA4 Synonyms:NACRA4; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P43681 |
PRO Name | neuronal acetylcholine receptor subunit alpha-4 (human) |
Definition | A neuronal acetylcholine receptor subunit alpha-4 that is encoded in the genome of human. |
Short Label | hCHRNA4 |
Category | organism-gene |
P43681 (CHRNA4) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
R10 | Methylation | score1 | PhosphoSitePlus | |||
R25 | Methylation | score1 | PhosphoSitePlus | |||
R33 | Methylation | score1 | PhosphoSitePlus | |||
S196 | Phosphorylation | score1 | PhosphoSitePlus | |||
S362 | Phosphorylation | score3 | neXtProt PhosphoSitePlus | 12124445 | ||
S380 | Phosphorylation | score1 | IEDB | 35494241 | ||
S467 | Phosphorylation | score3 | neXtProt PhosphoSitePlus | 12124445 | ||
S488 | Phosphorylation | score1 | PhosphoSitePlus | |||
S538 | Phosphorylation | score1 | PhosphoSitePlus | |||
S539 | Phosphorylation | score1 | PhosphoSitePlus | |||
S543 | Phosphorylation | score1 | PhosphoSitePlus | |||
T545 | Phosphorylation | score1 | PhosphoSitePlus | |||
S550 | Phosphorylation | score1 | PhosphoSitePlus | |||
S561 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
R33 | W33 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
R33 | Q33 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
R33 | L33 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S196 | R196 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S362 | P362 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
S539 | W539 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S539 | L539 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
T545 | M545 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] | |
T545 | R545 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
S561 | P561 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S561 | L561 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] |