Protein Information

Cytoscape View


UniProt AC / UniProt ID P43403 / ZAP70_HUMAN
Protein Name Tyrosine-protein kinase ZAP-70
Gene Name Name: ZAP70
Synonyms:SRK;
Organism Homo sapiens (Human)

PRO ID PR:P43403
DAG View
PRO Name tyrosine-protein kinase ZAP-70 (human)
Definition A tyrosine-protein kinase ZAP-70 that is encoded in the genome of human.
Short Label hZAP70
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P43403 (ZAP70) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y12 Phosphorylation PhosphoSitePlus
K25 Ubiquitination PhosphoSitePlus
Y46 Phosphorylation PhosphoSitePlus
Y69 Phosphorylation P06239 (LCK) PhosphoSitePlus   RLIMS-P   Signor 7961936, 23874979
K75 Ubiquitination PhosphoSitePlus
Y87 Phosphorylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
Y126 Phosphorylation P43403 (ZAP70) , P06239 (LCK) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 8756661, 10037717, 7961936
K132 Ubiquitination PhosphoSitePlus
Y164 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
S167 Phosphorylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
Y178 Phosphorylation P06239 (LCK) PhosphoSitePlus   RLIMS-P   Signor 7961936
S179 Phosphorylation PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
T197 Phosphorylation PhosphoSitePlus
Y198 Phosphorylation PhosphoSitePlus
Y204 Phosphorylation PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
Y209 Phosphorylation PhosphoSitePlus
Y211 Phosphorylation PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
Y221 Phosphorylation PhosphoSitePlus
Y248 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455, 15659558, 17192257
S257 Phosphorylation PhosphoSitePlus
S258 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
T278 Phosphorylation PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
S289 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15144186
Y292 Phosphorylation P06239 (LCK) , P43403 (ZAP70) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18548611, 7961936, 8943331, ...16094384, 25682964, 10779765, 23874979, 15144186, 15592455, 10037717, 9407100, 8756661, 9199177, 15659558, 26237552, 19690332, 17192257
T293 Phosphorylation PhosphoSitePlus
T300 Phosphorylation PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
T312 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
Y315 Phosphorylation P06239 (LCK) , P43403 (ZAP70) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 7798261, 18779373, 16339550, ...16094384, 9151714, 8756661, 10037717, 21103055, 11828374, 15592455, 12522270, 26237552
S317 Phosphorylation PhosphoSitePlus
Y319 Phosphorylation P00519 (ABL1) , P43403 (ZAP70) , P06239 (LCK) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10318843, 15996927, 18378687, ...26783323, 17942891, 12522270, 27210755, 10202147, 15292262, 21103055, 23758320, 20682913, 17250586, 15337788, 8756661, 10037717, 15592455, 26237552, 16094384, 22665519, 15268851, 11970985
S320 Phosphorylation PhosphoSitePlus
S351 Phosphorylation PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
Y397 Phosphorylation PhosphoSitePlus   RLIMS-P 23874979
Y451 Phosphorylation PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
Y474 Phosphorylation P06239 (LCK) phospho.ELM   PhosphoSitePlus   Signor 9685404
K476 Ubiquitination PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus
Y492 Phosphorylation P06239 (LCK) , P43403 (ZAP70) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15659558, 9199177, 16094384, ...16049944, 17192257, 23874979, 8756661, 7961936, 7642520, 8955094, 23620790, 15592455, 12522270, 7781602, 11270871, 26237552
Y493 Phosphorylation P06239 (LCK) , P43403 (ZAP70) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18548611, 15659558, 11514606, ...23874979, 8955094, 26783323, 12522270, 7961936, 27941787, 21103055, 7781602, 11270871, 21757751, 23758320, 15144186, 8756661, 15592455, 26237552, 7642520, 11976341, 16094384, 16049944, 27253329, 9199177, 24493801
T494 Phosphorylation PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
Y506 Phosphorylation PhosphoSitePlus
S520 Phosphorylation PhosphoSitePlus   RLIMS-P 14560012
S534 Phosphorylation PhosphoSitePlus
Y535 Phosphorylation PhosphoSitePlus
K538 Ubiquitination PhosphoSitePlus
K544 Ubiquitination PhosphoSitePlus   UniProt 26903241
K556 Ubiquitination PhosphoSitePlus
Y569 Phosphorylation PhosphoSitePlus
Y597 Phosphorylation PhosphoSitePlus
Y598 Phosphorylation PhosphoSitePlus   RLIMS-P 23874979
S599 Phosphorylation PhosphoSitePlus
K603 Acetylation PhosphoSitePlus   UniProt 19608861
K603 Ubiquitination PhosphoSitePlus
T611 Phosphorylation PhosphoSitePlus
K613 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y69 Phosphorylation P06239 (LCK) HPRD 7961936
Y126 Phosphorylation P43403 (ZAP70) HPRD 7961936
Y178 Phosphorylation P06239 (LCK) HPRD 7961936
Y248 Phosphorylation HPRD 15592455
S289 Phosphorylation HPRD 15144186
Y292 Phosphorylation P43403 (ZAP70) HPRD 19901323, 7961936, 15144186
T293 Phosphorylation HPRD 15144186
Y315 Phosphorylation P43403 (ZAP70) HPRD   PRO 10037717
Y319 Phosphorylation P43403 (ZAP70) , P06239 (LCK) HPRD 10318843, 7961936
Y474 Phosphorylation P06239 (LCK) HPRD 7961936, 9685404
Y492 Phosphorylation P06239 (LCK) HPRD 7961936
Y493 Phosphorylation P06239 (LCK) HPRD   PRO 7961936, 15144186
T494 Phosphorylation HPRD 15144186
Site PTM Type PTM Enzyme Score Source PMID
Y8 Phosphorylation P43403 (ZAP70) HPRD 10037717
Y12 Phosphorylation P43403 (ZAP70) , P06239 (LCK) HPRD 10318843, 7961936
Y167 Phosphorylation P29353 (SHC1) , P06239 (LCK) HPRD 7961936, 9685404
Y185 Phosphorylation P06239 (LCK) HPRD 7961936
Y186 Phosphorylation P06239 (LCK) HPRD 7961936, 15144186
T187 Phosphorylation HPRD 15144186


P43403 (ZAP70) as PTM Enzyme



Substrate Site Score Source PMID
O43561-4 (LAT) Y126 HPRD 11368773
O43561-2 (LAT) Y127 HPRD   neXtProt   PhosphoSitePlus 11368773
O43561-4 (LAT) Y131 HPRD 11368773
O43561-2 (LAT) Y132 HPRD   neXtProt   PhosphoSitePlus 11368773
O43561-1 (LAT) Y156 HPRD   Signor 11368773
O43561 (LAT) Y161 HPRD   Signor 11368773
O43561-3 (LAT) Y163 HPRD 11368773
O43561-3 (LAT) Y168 HPRD 11368773
O43561-4 (LAT) Y170 HPRD 11368773
O43561-2 (LAT) Y171 HPRD   neXtProt   PhosphoSitePlus 11368773
O43561-4 (LAT) Y190 HPRD 11368773
O43561-2 (LAT) Y191 HPRD   neXtProt   PhosphoSitePlus 11368773
O43561-1 (LAT) Y200 HPRD   Signor 11368773
O43561-3 (LAT) Y207 HPRD 11368773
O43561-1 (LAT) Y220 HPRD   Signor 11368773
O43561-4 (LAT) Y225 HPRD 11368773
O43561-2 (LAT) Y226 HPRD   neXtProt   PhosphoSitePlus 11368773
O43561-3 (LAT) Y227 HPRD 11368773
O43561 (LAT) Y255 HPRD   Signor 11368773
O43561-3 (LAT) Y262 HPRD 11368773
P15941-7 (MUC1) Y229 HPRD 14766232
P15941-11 (MUC1) Y238 HPRD 14766232
P15941 (MUC1) Y1203 Signor 14766232
P19174 (PLCG1) Y783 neXtProt 15161916
P19174 (PLCG1) Y1253 neXtProt 15161916
P29353-7 (SHC1) Y239 HPRD   neXtProt   PhosphoSitePlus 17016520, 19901323, 17389395, ...9710204, 10482988, 9388490, 9685404, 20068231, 16497976
P29353-2 (SHC1) Y240 HPRD   neXtProt   PhosphoSitePlus 19901323, 9388490, 17389395, ...9710204, 10482988, 9096689, 16497976, 20068231, 9685404
P29353-2 (SHC1) Y317 PhosphoSitePlus 9710204
P29353 (SHC1) Y349 HPRD   phospho.ELM   Signor 17016520, 19901323, 17389395, ...9710204, 15688026, 16497976, 20068231, 9685404
P29353 (SHC1) Y350 HPRD   phospho.ELM   Signor 19901323, 17389395, 9710204, ...15688026, 9685404, 20068231, 16497976
P29353 (SHC1) Y427 HPRD   phospho.ELM   Signor 18578522, 9710204, 9741627, ...10921922, 10482988, 10764799, 16497976, 20230923, 10896916, 18452278, 9121430, 12237775, 11075717, 17389395, 19651622, 17016520, 10816433, 19664994, 18669648, 9446569, 19901323, 20068231
P43403-2 (ZAP70) Y8 HPRD 10037717
P43403-2 (ZAP70) Y12 HPRD 7961936
P43403 (ZAP70) Y126 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 8756661, 10037717, 7961936
P43403-1 (ZAP70) Y292 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 19901323, 8756661, 10037717, ...7961936, 15144186
P43403 (ZAP70) Y315 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 8756661, 10037717, 7798261, ...11828374
P43403 (ZAP70) Y319 HPRD   neXtProt   PhosphoSitePlus   Signor 8756661, 10037717, 7961936
P43403 (ZAP70) Y492 phospho.ELM   PhosphoSitePlus 8756661, 11270871, 7642520, ...7961936, 16049944
P43403 (ZAP70) Y493 phospho.ELM   PhosphoSitePlus   Signor 8756661, 11270871, 7642520, ...7961936, 16049944
P51452 (DUSP3) Y38 neXtProt   PhosphoSitePlus 12447358
P51452 (DUSP3) Y138 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 12447358
Q13094 (LCP2) Y113 HPRD   phospho.ELM   PhosphoSitePlus   Signor 8702662, 12817019, 10660534, ...9047237
Q13094 (LCP2) Y128 HPRD   phospho.ELM   PhosphoSitePlus   Signor 8702662, 12817019, 10660534, ...9047237
Q13094 (LCP2) Y145 HPRD   phospho.ELM   PhosphoSitePlus   Signor 8702662, 12817019, 8892604
Q13094 (LCP2) Y423 Signor 8702662
Q13094 (LCP2) Y426 Signor 8702662
Q16539 (MAPK14) Y323 neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 15735648
Q8N1K5 (THEMIS) Y540 PhosphoSitePlus 23460737
Q8N1K5 (THEMIS) Y541 PhosphoSitePlus 23460737
Q9UJU6 (DBNL) Y334 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14557276
Q9UJU6-2 (DBNL) Y335 HPRD 14557276
Q9UJU6 (DBNL) Y344 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 14557276
Q9UJU6-2 (DBNL) Y345 HPRD 14557276
Q9UQC2 (GAB2) Y614 HPRD   phospho.ELM   PhosphoSitePlus   Signor 11572860
Q9UQQ2 (SH2B3) Y273 HPRD   phospho.ELM   Signor 9169414


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049722 (hZAP70/Phos:2) pY315,pY493 PRO
PR:000049723 (hZAP70/Phos:3) pY493 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P43403 (ZAP70) Y319 P06239 (LCK) unknown eFIP 10318843


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036592 (hEZR/iso:1/Phos:5) Interaction PR:P43403 (hZAP70) PRO 18025306