iPTMnet Report P43250 GRK6

Protein Information

UniProt AC / UniProt ID	P43250 / GRK6_HUMAN
Protein Name	G protein-coupled receptor kinase 6
Gene Name	Name: GRK6 Synonyms:GPRK6;
Organism	Homo sapiens (Human)

PRO ID	PR:P43250 DAG View
PRO Name	G protein-coupled receptor kinase 6 (human)
Definition	A G protein-coupled receptor kinase 6 that is encoded in the genome of human.
Short Label	hGRK6
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P43250 (GRK6) as Substrate

Condensed View

Search:

Site Select all By amino acid All Serine All Threonine By position T10 K14 C42 T106 S111 T113 K139 K183 K194 K210 K226 K235 K240 K313 K343 K358 K402 K426 K443 K466 S484 T485 K487 S557 S566 S568	PTM Type Select all Acetylation Methylation Phosphorylation Ubiquitination	PTM Enzyme Select all P43250 (GRK6)	Score Select all 1 3 4	Source Select all IEDB PhosphoSitePlus UniProt neXtProt phospho.ELM	PMID
T10	Phosphorylation		score1	PhosphoSitePlus
K14	Ubiquitination		score1	PhosphoSitePlus
C42	Methylation		score1	IEDB	31844290
T106	Phosphorylation		score1	PhosphoSitePlus
S111	Phosphorylation		score1	PhosphoSitePlus
T113	Phosphorylation		score1	PhosphoSitePlus
K139	Ubiquitination		score1	PhosphoSitePlus
K183	Ubiquitination		score1	PhosphoSitePlus
K194	Ubiquitination		score1	PhosphoSitePlus
K210	Ubiquitination		score1	PhosphoSitePlus
K226	Ubiquitination		score1	PhosphoSitePlus
K235	Acetylation		score1	PhosphoSitePlus
K235	Ubiquitination		score1	PhosphoSitePlus
K240	Acetylation		score1	PhosphoSitePlus
K240	Ubiquitination		score1	PhosphoSitePlus
K313	Ubiquitination		score1	PhosphoSitePlus
K343	Ubiquitination		score1	PhosphoSitePlus
K358	Ubiquitination		score1	PhosphoSitePlus
K402	Ubiquitination		score1	PhosphoSitePlus
K426	Ubiquitination		score1	PhosphoSitePlus
K443	Ubiquitination		score1	PhosphoSitePlus
K466	Ubiquitination		score1	PhosphoSitePlus
S484	Phosphorylation		score4	neXtProt phospho.ELM PhosphoSitePlus UniProt	10334944, 18669648, 17081983, ...19690332
S484	Phosphorylation	P43250 (GRK6)	score3	neXtProt PhosphoSitePlus	10334944
T485	Phosphorylation		score4	neXtProt phospho.ELM PhosphoSitePlus UniProt	10334944, 18669648, 19690332, ...17081983
T485	Phosphorylation	P43250 (GRK6)	score3	neXtProt PhosphoSitePlus	10334944
K487	Ubiquitination		score1	PhosphoSitePlus
S557	Phosphorylation		score1	PhosphoSitePlus
S566	Phosphorylation		score1	PhosphoSitePlus
S568	Phosphorylation		score1	PhosphoSitePlus

Search:

Site Select all By amino acid All Serine All Threonine By position S484 T485	PTM Type Select all Phosphorylation	PTM Enzyme Select all P43250 (GRK6)	Score Select all 2	Source Select all HPRD	PMID
S484	Phosphorylation		score2	HPRD	10334944, 18691976, 18669648
S484	Phosphorylation	P43250 (GRK6)	score2	HPRD	10334944, 18691976, 18669648
T485	Phosphorylation		score2	HPRD	10334944, 18669648
T485	Phosphorylation	P43250 (GRK6)	score2	HPRD	10334944, 18669648

Search:

Site Select all By amino acid All Serine All Threonine By position S484 T485 S573 S578	PTM Type Select all Phosphorylation	PTM Enzyme Select all P43250 (GRK6)	Score Select all 1 2	Source Select all HPRD PhosphoSitePlus	PMID
S484	Phosphorylation		score2	HPRD	10334944, 18691976, 18669648
S484	Phosphorylation	P43250 (GRK6)	score2	HPRD	10334944, 18691976, 18669648
T485	Phosphorylation		score2	HPRD	10334944, 18669648
T485	Phosphorylation	P43250 (GRK6)	score2	HPRD	10334944, 18669648
S573	Phosphorylation		score1	PhosphoSitePlus
S578	Phosphorylation		score1	PhosphoSitePlus

Search:

Site Select all By amino acid All Serine All Threonine By position S484 T485	PTM Type Select all Phosphorylation	PTM Enzyme Select all P43250 (GRK6)	Score Select all 2	Source Select all HPRD	PMID
S484	Phosphorylation		score2	HPRD	10334944, 18691976, 18669648
S484	Phosphorylation	P43250 (GRK6)	score2	HPRD	10334944, 18691976, 18669648
T485	Phosphorylation		score2	HPRD	10334944, 18669648
T485	Phosphorylation	P43250 (GRK6)	score2	HPRD	10334944, 18669648

P43250 (GRK6) as PTM Enzyme

Protein as Phosphorylation Enzyme

Search:

Substrate Select all O14745-1 (NHERF1) O75581 (LRP6) P07550 (ADRB2) P08069 (IGF1R) P25963 (NFKBIA) P30411 (BDKRB2) P30411-1 (BDKRB2) P30411-2 (BDKRB2) P37840 (SNCA) P37840-1 (SNCA) P43250 (GRK6) P43250-1 (GRK6) P61073 (CXCR4) Q15722 (LTB4R)	Site Select all By amino acid All Serine All Threonine By position S9 S32 S36 S129 S290 T308 S324 S325 S330 S339 S346 S348 S355 S356 S366 S373 S375 S484 T485 S1321 S1448 S1490 S1508 T1572 S1590	Score Select all 1 2 3 4	Source Select all HPRD PhosphoSitePlus RLIMS-P+ Signor neXtProt	PMID
O14745-1 (NHERF1)	S290	score4	HPRD neXtProt Signor	19413330, 18088087, 10446210, ...15302935, 19664995, 18452278, 18669648, 20166139
O75581 (LRP6)	S1448	score2	neXtProt	19801552
O75581 (LRP6)	S1490	score2	neXtProt	19801552
O75581 (LRP6)	S1508	score2	neXtProt	19801552
O75581 (LRP6)	T1572	score2	neXtProt	19801552
O75581 (LRP6)	S1590	score2	neXtProt	19801552
P07550 (ADRB2)	S355	score3	PhosphoSitePlus	25770216, 21868357
P07550 (ADRB2)	S356	score3	PhosphoSitePlus	25770216, 21868357
P08069 (IGF1R)	S1321	score2	PhosphoSitePlus	22509025
P25963 (NFKBIA)	S32	score2	RLIMS-P+	25881508
P25963 (NFKBIA)	S36	score2	RLIMS-P+	25881508
P30411-2 (BDKRB2)	S346	score2	neXtProt	11517230
P30411-2 (BDKRB2)	S348	score2	neXtProt	11517230
P30411 (BDKRB2)	S366	score2	HPRD Signor	11517230
P30411-1 (BDKRB2)	S373	score2	HPRD Signor	11517230
P30411 (BDKRB2)	S375	score2	HPRD Signor	11517230
P37840-1 (SNCA)	S9	score1	HPRD	10852916
P37840 (SNCA)	S129	score2	neXtProt	19410557
P43250-1 (GRK6)	S484	score4	HPRD neXtProt PhosphoSitePlus	10334944, 18691976, 18669648
P43250 (GRK6)	T485	score4	HPRD neXtProt PhosphoSitePlus	10334944, 18669648
P61073 (CXCR4)	S324	score3	neXtProt PhosphoSitePlus	20048153
P61073 (CXCR4)	S325	score3	neXtProt PhosphoSitePlus	20048153
P61073 (CXCR4)	S330	score2	neXtProt	20048153
P61073 (CXCR4)	S339	score2	neXtProt	20048153
Q15722 (LTB4R)	T308	score4	HPRD PhosphoSitePlus	12077128, 20058876

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine By position K14 K226 K235 K313 K343 K466 K487 S573	Variant Select all N226 N235 N343 N466 N487 P573 R313 T14	Source Select all Biomuta	Disease [Sample source] Select all DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K14	T14	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
K226	N226	Biomuta	DOID:3571 / liver cancer [ cosmic ]
K235	N235	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc ]
K313	R313	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
K343	N343	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K466	N466	Biomuta	DOID:3571 / liver cancer [ cosmic ]
K487	N487	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S573	P573	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P43250 (GRK6)

Protein Information

Interactive Sequence View

P43250 (GRK6) as Substrate

P43250 (GRK6) as PTM Enzyme

PTM sites affected in variants