Protein Information

Cytoscape View


UniProt AC / UniProt ID P43250 / GRK6_HUMAN
Protein Name G protein-coupled receptor kinase 6
Gene Name Name: GRK6
Synonyms:GPRK6;
Organism Homo sapiens (Human)

PRO ID PR:P43250
DAG View
PRO Name G protein-coupled receptor kinase 6 (human)
Definition A G protein-coupled receptor kinase 6 that is encoded in the genome of human.
Short Label hGRK6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P43250 (GRK6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T10 Phosphorylation PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
T106 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
T113 Phosphorylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
K235 Acetylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K240 Acetylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
S484 Phosphorylation P43250 (GRK6) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 10334944, 18669648, 17081983, ...19690332
T485 Phosphorylation P43250 (GRK6) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 10334944, 18669648, 19690332, ...17081983
K487 Ubiquitination PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
S566 Phosphorylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S484 Phosphorylation P43250 (GRK6) HPRD 10334944, 18691976, 18669648
T485 Phosphorylation P43250 (GRK6) HPRD 10334944, 18669648
Site PTM Type PTM Enzyme Score Source PMID
S484 Phosphorylation P43250 (GRK6) HPRD 10334944, 18691976, 18669648
T485 Phosphorylation P43250 (GRK6) HPRD 10334944, 18669648
S573 Phosphorylation PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S484 Phosphorylation P43250 (GRK6) HPRD 10334944, 18691976, 18669648
T485 Phosphorylation P43250 (GRK6) HPRD 10334944, 18669648


P43250 (GRK6) as PTM Enzyme



Substrate Site Score Source PMID
O14745 (SLC9A3R1) S290 HPRD   neXtProt   Signor 19413330, 18088087, 10446210, ...15302935, 19664995, 18452278, 18669648, 20166139
O75581 (LRP6) S1448 neXtProt 19801552
O75581 (LRP6) S1490 neXtProt 19801552
O75581 (LRP6) S1508 neXtProt 19801552
O75581 (LRP6) T1572 neXtProt 19801552
O75581 (LRP6) S1590 neXtProt 19801552
P07550 (ADRB2) S355 PhosphoSitePlus 25770216, 21868357
P07550 (ADRB2) S356 PhosphoSitePlus 25770216, 21868357
P08069 (IGF1R) S1321 PhosphoSitePlus 22509025
P25963 (NFKBIA) S32 RLIMS-P+ 25881508
P25963 (NFKBIA) S36 RLIMS-P+ 25881508
P30411-2 (BDKRB2) S346 neXtProt 11517230
P30411-2 (BDKRB2) S348 neXtProt 11517230
P30411 (BDKRB2) S366 HPRD   Signor 11517230
P30411 (BDKRB2) S373 HPRD   Signor 11517230
P30411-1 (BDKRB2) S375 HPRD   Signor 11517230
P37840-1 (SNCA) S9 HPRD 10852916
P37840 (SNCA) S129 neXtProt 19410557
P43250 (GRK6) S484 HPRD   neXtProt   PhosphoSitePlus 10334944, 18691976, 18669648
P43250-3 (GRK6) T485 HPRD   neXtProt   PhosphoSitePlus 10334944, 18669648
P61073 (CXCR4) S324 neXtProt   PhosphoSitePlus 20048153
P61073 (CXCR4) S325 neXtProt   PhosphoSitePlus 20048153
P61073 (CXCR4) S330 neXtProt 20048153
P61073 (CXCR4) S339 neXtProt 20048153
Q15722 (LTB4R) T308 HPRD   PhosphoSitePlus 12077128, 20058876


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K226 N226 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K235 N235 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K313 R313 Biomuta DOID:363 / uterine cancer [ tcga ]
K343 N343 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]