iPTMnet Report for P42771 (CDKN2A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P42771 / CDN2A_HUMAN
Protein Name Cyclin-dependent kinase inhibitor 2A
Gene Name Name: CDKN2A
Synonyms:CDKN2,MTS1;
Organism Homo sapiens (Human)

PRO ID PR:P42771
DAG View
PRO Name cyclin-dependent kinase inhibitor 2A, isoforms h1/h2/h3/h5 (human)
Definition A cyclin-dependent kinase inhibitor 2A (human), isoforms h1, h2, h3, and h5.
Short Label hCDKN2A/iso:[1/2/3/5]
Category organism-seqgroup

Interactive Sequence View

Select/align proteoforms across species


P42771 (CDKN2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378
S7 Phosphorylation Q13535 (ATR) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 28120917, 21270107, 12529334
S8 Phosphorylation O14920 (IKBKB) , Q13535 (ATR) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21270107, 28120917, 20152798, ...12529334
Y44 Phosphorylation PhosphoSitePlus
R99 Methylation PhosphoSitePlus
R131 Methylation PhosphoSitePlus
R138 Methylation PhosphoSitePlus
S140 Phosphorylation Q13535 (ATR) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 28120917, 21270107, 12529334
S152 Phosphorylation Q13535 (ATR) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 28120917, 21270107, 12529334
Site PTM Type PTM Enzyme Score Source PMID
S76 Phosphorylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P42771 (CDKN2A) S152 P11802 (CDK4) unknown eFIP 28120917


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S7 C7 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S7 R7 Biomuta DOID:1324 / lung cancer [ cosmic ]
S8 I8 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S8 R8 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
Y44 * Biomuta DOID:1324 / lung cancer [ cosmic, tcga ] DOID:2394 / ovarian cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
Y44 C44 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y44 S44 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R99 W99 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
R99 Q99 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
R99 P99 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
R131 P131 Biomuta DOID:1324 / lung cancer [ cosmic ]
R131 C131 Biomuta [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
R131 L131 Biomuta DOID:4362 / cervical cancer [ cosmic ]
R131 H131 Biomuta [ cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
R138 I138 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R138 K138 Biomuta DOID:4159 / skin cancer [ cosmic ]
R138 T138 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
S140 N140 Biomuta DOID:4159 / skin cancer [ cosmic ]
S140 C140 Biomuta DOID:2394 / ovarian cancer [ cosmic ]