iPTMnet Report for P42771 (CDKN2A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P42771 / CDN2A_HUMAN
Protein Name Cyclin-dependent kinase inhibitor 2A
Gene Name Name: CDKN2A
Synonyms:CDKN2,MTS1;
Organism Homo sapiens (Human)

PRO ID PR:P42771
DAG View
PRO Name cyclin-dependent kinase inhibitor 2A, isoforms h1/h2/h3/h5 (human)
Definition A cyclin-dependent kinase inhibitor 2A (human), isoforms h1, h2, h3, and h5.
Short Label hCDKN2A/iso:[1/2/3/5]
Category organism-seqgroup

Interactive Sequence View

Select/align proteoforms across species


P42771 (CDKN2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378
S7 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 28120917, 21270107, 12529334
S7 Phosphorylation Q13535 (ATR) PhosphoSitePlus 21270107
S8 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21270107, 28120917, 20152798, ...12529334
S8 Phosphorylation O14920 (IKBKB) PhosphoSitePlus   Signor 20152798
S8 Phosphorylation Q13535 (ATR) PhosphoSitePlus 21270107
Y44 Phosphorylation PhosphoSitePlus
R99 Methylation PhosphoSitePlus
R131 Methylation PhosphoSitePlus
R138 Methylation PhosphoSitePlus
S140 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 28120917, 21270107, 12529334
S140 Phosphorylation Q13535 (ATR) PhosphoSitePlus 21270107
S152 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 28120917, 21270107, 12529334
S152 Phosphorylation Q13535 (ATR) PhosphoSitePlus 21270107
Site PTM Type PTM Enzyme Score Source PMID
S76 Phosphorylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P42771 (CDKN2A) S152 P11802 (CDK4) unknown eFIP 28120917


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S7 C7 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S7 R7 Biomuta DOID:1324 / lung cancer [ cosmic ]
S8 I8 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S8 R8 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
Y44 * Biomuta DOID:1324 / lung cancer [ cosmic, tcga ] DOID:2394 / ovarian cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
Y44 C44 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y44 S44 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R99 W99 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
R99 Q99 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
R99 P99 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
R131 P131 Biomuta DOID:1324 / lung cancer [ cosmic ]
R131 C131 Biomuta [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
R131 L131 Biomuta DOID:4362 / cervical cancer [ cosmic ]
R131 H131 Biomuta [ cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
R138 I138 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R138 K138 Biomuta DOID:4159 / skin cancer [ cosmic ]
R138 T138 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
S140 N140 Biomuta DOID:4159 / skin cancer [ cosmic ]
S140 C140 Biomuta DOID:2394 / ovarian cancer [ cosmic ]