iPTMnet Report for P42768 (WAS)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P42768 / WASP_HUMAN
Protein Name Actin nucleation-promoting factor WAS
Gene Name Name: WAS
Synonyms:IMD2;
Organism Homo sapiens (Human)

PRO ID PR:P42768
DAG View
PRO Name actin nucleation-promoting factor WAS (human)
Definition An actin nucleation-promoting factor WAS that is encoded in the genome of human.
Short Label hWAS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P42768 (WAS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
K76 Sumoylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
Y83 Phosphorylation PhosphoSitePlus
Y102 Phosphorylation PhosphoSitePlus   RLIMS-P+ 27694894
Y102 Phosphorylation Q9UM73 (ALK) RLIMS-P+ 27694894
K144 Sumoylation PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
K147 Sumoylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus   UniProt 23186163
S234 Phosphorylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
S277 Phosphorylation neXtProt   PhosphoSitePlus 16257963
S277 Phosphorylation Q07912 (TNK2) neXtProt 16257963
T282 Phosphorylation PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
Y291 Phosphorylation HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17890224, 16257963, 18088087, ...16472662, 12769847, 12769846, 10068673, 22665495, 14707117, 9742969, 12235133, 18083107, 15592455, 19901323, 19690332, 16497976
Y291 Phosphorylation P00519 (ABL1) PhosphoSitePlus 12769846
Y291 Phosphorylation P06239 (LCK) PhosphoSitePlus 12769846
Y291 Phosphorylation P06241 (FYN) neXtProt 14707117
Y291 Phosphorylation P07948 (LYN) PhosphoSitePlus 12769846
Y291 Phosphorylation P08631 (HCK) HPRD   phospho.ELM 19901323, 18088087, 12769846, ...10068673, 9742969, 12235133, 16497976
Y291 Phosphorylation Q06187 (BTK) HPRD   phospho.ELM   Signor 19901323, 18088087, 12769846, ...10068673, 9742969, 12235133, 16497976
Y291 Phosphorylation Q07912 (TNK2) neXtProt   PhosphoSitePlus 16257963, 16472662
S320 Phosphorylation PhosphoSitePlus
R321 Methylation PhosphoSitePlus
R328 Methylation PhosphoSitePlus
R338 Methylation PhosphoSitePlus
T355 Phosphorylation HPRD   PhosphoSitePlus 18452278
R357 Methylation PhosphoSitePlus
R364 Methylation PhosphoSitePlus
R377 Methylation PhosphoSitePlus
R431 Methylation PhosphoSitePlus
R439 Methylation PhosphoSitePlus
S483 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18088087, 16606694, 19690332, ...12769847
S483 Phosphorylation P19784 (CSNK2A2) HPRD   Signor 18088087, 12769847
S483 Phosphorylation P68400 (CSNK2A1) HPRD   PhosphoSitePlus   Signor 18088087, 12769847
S484 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18088087, 16606694, 12769847
S484 Phosphorylation P19784 (CSNK2A2) HPRD   Signor 18088087, 12769847
S484 Phosphorylation P68400 (CSNK2A1) HPRD   PhosphoSitePlus   Signor 18088087, 12769847


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000045784 (hWAS/InitMet-/Phos:1) pY291 PRO 12235133, 12769846


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K81 T81 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y102 H102 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S221 R221 Biomuta DOID:1324 / lung cancer [ cosmic ]
K235 I235 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
R321 P321 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R321 G321 Biomuta DOID:1324 / lung cancer [ cosmic ]
R338 C338 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R338 H338 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc, tcga ]
R377 H377 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]