Protein Information

Cytoscape View

UniProt AC / UniProt ID P42768 / WASP_HUMAN
Protein Name Wiskott-Aldrich syndrome protein
Gene Name Name: WAS
Organism Homo sapiens (Human)

PRO ID PR:P42768
DAG View
PRO Name Wiskott-Aldrich syndrome protein (human)
Definition A Wiskott-Aldrich syndrome protein that is encoded in the genome of human.
Short Label hWAS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P42768 (WAS) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
K76 Sumoylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
Y83 Phosphorylation PhosphoSitePlus
Y102 Phosphorylation Q9UM73 (ALK) PhosphoSitePlus   RLIMS-P+ 27694894
K144 Sumoylation PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
K147 Sumoylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus   UniProt 23186163
S234 Phosphorylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
S277 Phosphorylation Q07912 (TNK2) neXtProt   PhosphoSitePlus 16257963
T282 Phosphorylation PhosphoSitePlus
T286 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
Y291 Phosphorylation P07948 (LYN) , P06239 (LCK) , P00519 (ABL1) , Q07912 (TNK2) , Q06187 (BTK) , P08631 (HCK) , P06241 (FYN) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17890224, 16257963, 18088087, ...16472662, 12769847, 12769846, 10068673, 22665495, 14707117, 9742969, 12235133, 18083107, 15592455, 19901323, 19690332, 16497976
S320 Phosphorylation PhosphoSitePlus
R321 Methylation PhosphoSitePlus
R328 Methylation PhosphoSitePlus
R338 Methylation PhosphoSitePlus
T355 Phosphorylation HPRD   PhosphoSitePlus 18452278
R357 Methylation PhosphoSitePlus
R364 Methylation PhosphoSitePlus
R377 Methylation PhosphoSitePlus
R431 Methylation PhosphoSitePlus
R439 Methylation PhosphoSitePlus
S483 Phosphorylation P19784 (CSNK2A2) , P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18088087, 16606694, 19690332, ...12769847
S484 Phosphorylation P68400 (CSNK2A1) , P19784 (CSNK2A2) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18088087, 16606694, 12769847

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K81 T81 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y83 H83 Biomuta DOID:363 / uterine cancer [ tcga ]
S221 R221 Biomuta DOID:1324 / lung cancer [ cosmic ]
K235 I235 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R321 P321 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
R338 C338 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
R338 H338 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
R377 H377 Biomuta DOID:3070 / malignant glioma [ tcga ]
S483 F483 Biomuta DOID:3070 / malignant glioma [ tcga ]