iPTMnet Report P42768 WAS

Protein Information

UniProt AC / UniProt ID	P42768 / WASP_HUMAN
Protein Name	Actin nucleation-promoting factor WAS
Gene Name	Name: WAS Synonyms:IMD2;
Organism	Homo sapiens (Human)

PRO ID	PR:P42768 DAG View
PRO Name	actin nucleation-promoting factor WAS (human)
Definition	An actin nucleation-promoting factor WAS that is encoded in the genome of human.
Short Label	hWAS
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P42768 (WAS) as Substrate

P42768

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S2 K76 K81 Y83 Y102 K144 K147 S221 S234 K235 S277 T282 T286 S287 Y291 S320 R321 R328 R338 T355 R357 R364 R377 R431 R439 S483 S484	PTM Type Select all Methylation Phosphorylation Sumoylation Ubiquitination	PTM Enzyme	Score Select all 1 2 3 4	Source Select all HPRD PRO PhosphoSitePlus RLIMS-P RLIMS-P+ Signor UniProt neXtProt phospho.ELM	PMID
S2	Phosphorylation		score1	PhosphoSitePlus
K76	Sumoylation		score1	PhosphoSitePlus
K76	Ubiquitination		score1	PhosphoSitePlus
K81	Ubiquitination		score1	PhosphoSitePlus
Y83	Phosphorylation		score1	PhosphoSitePlus
Y102	Phosphorylation	Q9UM73 (ALK)	score3	PhosphoSitePlus RLIMS-P+	27694894
K144	Sumoylation		score1	PhosphoSitePlus
K144	Ubiquitination		score1	PhosphoSitePlus
K147	Sumoylation		score1	PhosphoSitePlus
K147	Ubiquitination		score1	PhosphoSitePlus
S221	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
S234	Phosphorylation		score1	PhosphoSitePlus
K235	Ubiquitination		score1	PhosphoSitePlus
S277	Phosphorylation	Q07912 (TNK2)	score3	neXtProt PhosphoSitePlus	16257963
T282	Phosphorylation		score1	PhosphoSitePlus
T286	Phosphorylation		score1	PhosphoSitePlus
S287	Phosphorylation		score1	PhosphoSitePlus
Y291	Phosphorylation	P07948 (LYN) , P06239 (LCK) , P00519 (ABL1) , Q07912 (TNK2) , P08631 (HCK) , P06241 (FYN) , Q06187 (BTK)	score4	HPRD neXtProt phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	17890224, 16257963, 18088087, ...16472662, 12769847, 12769846, 10068673, 22665495, 14707117, 9742969, 12235133, 18083107, 15592455, 19901323, 19690332, 16497976
S320	Phosphorylation		score1	PhosphoSitePlus
R321	Methylation		score1	PhosphoSitePlus
R328	Methylation		score1	PhosphoSitePlus
R338	Methylation		score1	PhosphoSitePlus
T355	Phosphorylation		score2	HPRD PhosphoSitePlus	18452278
R357	Methylation		score1	PhosphoSitePlus
R364	Methylation		score1	PhosphoSitePlus
R377	Methylation		score1	PhosphoSitePlus
R431	Methylation		score1	PhosphoSitePlus
R439	Methylation		score1	PhosphoSitePlus
S483	Phosphorylation	P19784 (CSNK2A2) , P68400 (CSNK2A1)	score4	HPRD phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	18088087, 16606694, 19690332, ...12769847
S484	Phosphorylation	P68400 (CSNK2A1) , P19784 (CSNK2A2)	score4	HPRD phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	18088087, 16606694, 12769847

Proteoforms

Search:

	PRO ID (Short Label) Select all PR:000045784 (hWAS/InitMet-/Phos:1)	Sites Select all pY291	PTM Enzyme	Source Select all PRO	PMID
	PR:000045784 (hWAS/InitMet-/Phos:1)	pY291		PRO	12235133, 12769846

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Tyrosine By position K81 Y102 S221 K235 R321 R338 R377	Variant Select all C338 G321 H102 H338 H377 I235 P321 R221 T81	Source Select all Biomuta	Disease [Sample source] Select all DOID:10283 / prostate cancer [ cosmic, icgc, tcga ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K81	T81	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
Y102	H102	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S221	R221	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K235	I235	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ]
R321	P321	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R321	G321	Biomuta	DOID:1324 / lung cancer [ cosmic ]
R338	C338	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R338	H338	Biomuta	DOID:10283 / prostate cancer [ cosmic, icgc, tcga ]
R377	H377	Biomuta	DOID:1319 / brain cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P42768 (WAS)

Protein Information

Interactive Sequence View

P42768 (WAS) as Substrate

Proteoforms

PTM sites affected in variants