iPTMnet Report P41743 PRKCI

Protein Information

UniProt AC / UniProt ID	P41743 / KPCI_HUMAN
Protein Name	Protein kinase C iota type
Gene Name	Name: PRKCI Synonyms:DXS1179E;
Organism	Homo sapiens (Human)

PRO ID	PR:P41743 DAG View
PRO Name	protein kinase C iota type (human)
Definition	A protein kinase C iota type that is encoded in the genome of human.
Short Label	hPRKCI
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P41743 (PRKCI) as Substrate

P41743

Condensed View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
P2	Acetylation		score1	UniProt	20068231
T3	Phosphorylation		score2	HPRD PhosphoSitePlus UniProt	20068231
S7	Phosphorylation		score2	HPRD PhosphoSitePlus UniProt	20068231
S8	Phosphorylation		score2	HPRD PhosphoSitePlus UniProt	20068231
T9	Phosphorylation		score2	HPRD PhosphoSitePlus UniProt	20068231
S11	Phosphorylation		score2	HPRD PhosphoSitePlus	20068231
T13	Phosphorylation		score2	HPRD PhosphoSitePlus	20068231
S19	Phosphorylation		score2	HPRD PhosphoSitePlus	20068231
S44	Phosphorylation		score1	PhosphoSitePlus
S46	Phosphorylation		score1	PhosphoSitePlus
S59	Phosphorylation		score1	PhosphoSitePlus
S82	Phosphorylation		score1	PhosphoSitePlus
Y125	Phosphorylation		score1	PhosphoSitePlus
K134	Acetylation		score1	PhosphoSitePlus
Y136	Phosphorylation		score1	PhosphoSitePlus
T142	Phosphorylation		score1	PhosphoSitePlus
K175	Acetylation		score1	PhosphoSitePlus
K184	Ubiquitination		score1	PhosphoSitePlus
Y219	Phosphorylation		score1	PhosphoSitePlus
S222	Phosphorylation		score1	PhosphoSitePlus
S223	Phosphorylation		score1	PhosphoSitePlus
S226	Phosphorylation		score1	PhosphoSitePlus
K234	Sumoylation		score1	PhosphoSitePlus
K244	Ubiquitination		score1	PhosphoSitePlus
S246	Phosphorylation		score1	PhosphoSitePlus
S247	Phosphorylation		score1	PhosphoSitePlus
Y265	Phosphorylation		score4	HPRD neXtProt Signor UniProt	16452474, 11891849, 11713277
Y265	Phosphorylation	P12931 (SRC)	score4	HPRD neXtProt Signor	16452474, 11713277
Y280	Phosphorylation		score4	HPRD neXtProt Signor UniProt	16452474, 11713277
Y280	Phosphorylation	P12931 (SRC)	score4	HPRD neXtProt Signor	16452474, 11713277
K287	Ubiquitination		score1	PhosphoSitePlus
Y334	Phosphorylation		score4	HPRD neXtProt Signor UniProt	16452474, 11713277
Y334	Phosphorylation	P12931 (SRC)	score4	HPRD neXtProt Signor	16452474, 11713277
K380	Ubiquitination		score1	PhosphoSitePlus
Y397	Phosphorylation		score1	PhosphoSitePlus
T409	Phosphorylation		score2	HPRD PhosphoSitePlus	18691976, 18669648, 20068231
T410	Phosphorylation		score2	HPRD PhosphoSitePlus	18669648
S411	Phosphorylation		score2	HPRD PhosphoSitePlus	18691976, 18669648
T412	Phosphorylation		score4	HPRD PhosphoSitePlus UniProt	16125198, 18669648, 18489133
T416	Phosphorylation		score3	HPRD PhosphoSitePlus	18489133
Y419	Phosphorylation		score1	PhosphoSitePlus
Y430	Phosphorylation		score1	PhosphoSitePlus
S459	Phosphorylation		score3	HPRD PhosphoSitePlus	18489133
K477	Ubiquitination		score1	PhosphoSitePlus
K488	Ubiquitination		score1	PhosphoSitePlus
K499	Ubiquitination		score1	PhosphoSitePlus
T557	Phosphorylation		score1	PhosphoSitePlus
T564	Phosphorylation		score4	HPRD PhosphoSitePlus UniProt	16125198, 21406692, 18452278, ...24275569, 18489133
Y584	Phosphorylation		score1	PhosphoSitePlus
S591	Phosphorylation		score3	HPRD PhosphoSitePlus	18489133
C595	S-Nitrosylation		score0	dbSNO	26338901

P41743 (PRKCI) as PTM Enzyme

Protein as Phosphorylation Enzyme

Substrate	Site	Score	Source	PMID
P04083 (ANXA1)	S27	score1	HPRD	2457390
P08151 (GLI1)	S243	score3	neXtProt PhosphoSitePlus	23446420
P08151 (GLI1)	T304	score3	neXtProt PhosphoSitePlus	23446420
P10636-8 (MAPT)	S258	score2	PhosphoSitePlus	11104762
P10636-8 (MAPT)	S293	score2	PhosphoSitePlus	11104762
P10636-8 (MAPT)	S324	score2	PhosphoSitePlus	11104762
P10636-8 (MAPT)	S352	score2	PhosphoSitePlus	11104762
P15311 (EZR)	T567	score3	neXtProt PhosphoSitePlus Signor	18270268
P27448 (MARK3)	T564	score2	PhosphoSitePlus	15084291
P29474 (NOS3)	T495	score1	Signor	24379783
P50613 (CDK7)	T170	score3	neXtProt PhosphoSitePlus	22021906
P51617 (IRAK1)	T66	score2	neXtProt	14684752
Q13464 (ROCK1)	T1024	score2	neXtProt	21685893
Q13464 (ROCK1)	S1333	score2	neXtProt	21685893
Q13464 (ROCK1)	T1334	score2	neXtProt	21685893
Q13464 (ROCK1)	T1337	score2	neXtProt	21685893
Q13464 (ROCK1)	S1341	score2	neXtProt	21685893
Q14247 (CTTN)	S261	score2	PhosphoSitePlus	24753582
Q15334 (LLGL1)	S659	score2	neXtProt	12725730
Q6P1M3 (LLGL2)	S653	score2	neXtProt	12725730
Q6STE5 (SMARCD3)	S247	score2	PhosphoSitePlus	23219531
Q7KZI7 (MARK2)	T596	score4	neXtProt PhosphoSitePlus	15084291, 15324659
Q8TEW0 (PARD3)	S827	score2	neXtProt	22579248
Q92934 (BAD)	S75	score4	neXtProt PhosphoSitePlus Signor	21419810, 15705582
Q92934 (BAD)	S99	score4	neXtProt PhosphoSitePlus Signor	21419810, 15705582
Q92934 (BAD)	S118	score4	neXtProt PhosphoSitePlus Signor	21419810, 15705582
Q969H0 (FBXW7)	S10	score2	PhosphoSitePlus	20815813
Q969H0 (FBXW7)	S18	score2	PhosphoSitePlus	20815813
Q9H8V3 (ECT2)	T359	score3	neXtProt PhosphoSitePlus Signor	21189248
Q9NPB6 (PARD6A)	S345	score2	PhosphoSitePlus	23249950
Q9UBS0 (RPS6KB2)	S473	score2	PhosphoSitePlus	12529391

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
P2	Q2	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S8	N8	Biomuta	DOID:263 / kidney cancer [ cosmic, icgc ]
S11	T11	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K134	R134	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y136	C136	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K234	*	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S246	A246	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S247	F247	Biomuta	DOID:363 / uterine cancer [ icgc ]
S247	P247	Biomuta	DOID:2394 / ovarian cancer [ cosmic, icgc ]
Y265	H265	Biomuta	[ cosmic ]
Y265	*	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
Y280	N280	Biomuta	DOID:4159 / skin cancer [ cosmic ]
Y419	S419	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
Y430	C430	Biomuta	DOID:1324 / lung cancer [ cosmic ]
Y430	D430	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S459	P459	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
S459	F459	Biomuta	DOID:4159 / skin cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic, icgc ]
S591	C591	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P41743 (PRKCI)

Protein Information

Interactive Sequence View

P41743 (PRKCI) as Substrate

P41743 (PRKCI) as PTM Enzyme

PTM sites affected in variants