Protein Information

Cytoscape View


UniProt AC / UniProt ID P41743 / KPCI_HUMAN
Protein Name Protein kinase C iota type
Gene Name Name: PRKCI
Synonyms:DXS1179E;
Organism Homo sapiens (Human)

PRO ID PR:P41743
DAG View
PRO Name protein kinase C iota type (human)
Definition A protein kinase C iota type that is encoded in the genome of human.
Short Label hPRKCI
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P41743 (PRKCI) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
P2 Acetylation UniProt 20068231
T3 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
S7 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
S8 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
T9 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
S11 Phosphorylation HPRD   PhosphoSitePlus 20068231
T13 Phosphorylation HPRD   PhosphoSitePlus 20068231
S19 Phosphorylation HPRD   PhosphoSitePlus 20068231
S44 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
Y125 Phosphorylation PhosphoSitePlus
K134 Acetylation PhosphoSitePlus
Y136 Phosphorylation PhosphoSitePlus
T142 Phosphorylation PhosphoSitePlus
K175 Acetylation PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
Y219 Phosphorylation PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
Y265 Phosphorylation P12931 (SRC) HPRD   neXtProt   Signor   UniProt 16452474, 11891849, 11713277
Y280 Phosphorylation P12931 (SRC) HPRD   neXtProt   Signor   UniProt 16452474, 11713277
K287 Ubiquitination PhosphoSitePlus
Y334 Phosphorylation P12931 (SRC) HPRD   neXtProt   Signor   UniProt 16452474, 11713277
K380 Ubiquitination PhosphoSitePlus
Y397 Phosphorylation PhosphoSitePlus
T409 Phosphorylation HPRD   PhosphoSitePlus 18691976, 18669648, 20068231
T410 Phosphorylation HPRD   PhosphoSitePlus 18669648
S411 Phosphorylation HPRD   PhosphoSitePlus 18691976, 18669648
T412 Phosphorylation HPRD   PhosphoSitePlus   UniProt 16125198, 18669648, 18489133
T416 Phosphorylation HPRD   PhosphoSitePlus 18489133
Y419 Phosphorylation PhosphoSitePlus
Y430 Phosphorylation PhosphoSitePlus
S459 Phosphorylation HPRD   PhosphoSitePlus 18489133
K477 Ubiquitination PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
K499 Ubiquitination PhosphoSitePlus
T557 Phosphorylation PhosphoSitePlus
T564 Phosphorylation HPRD   PhosphoSitePlus   UniProt 16125198, 21406692, 18452278, ...24275569, 18489133
Y584 Phosphorylation PhosphoSitePlus
S591 Phosphorylation HPRD   PhosphoSitePlus 18489133
C595 S-Nitrosylation dbSNO 26338901


P41743 (PRKCI) as PTM Enzyme



Substrate Site Score Source PMID
P04083 (ANXA1) S27 HPRD 2457390
P08151 (GLI1) S243 neXtProt   PhosphoSitePlus 23446420
P08151 (GLI1) T304 neXtProt   PhosphoSitePlus 23446420
P10636-8 (MAPT) S258 PhosphoSitePlus 11104762
P10636-8 (MAPT) S293 PhosphoSitePlus 11104762
P10636-8 (MAPT) S324 PhosphoSitePlus 11104762
P10636-8 (MAPT) S352 PhosphoSitePlus 11104762
P15311 (EZR) T567 neXtProt   PhosphoSitePlus   Signor 18270268
P27448 (MARK3) T564 PhosphoSitePlus 15084291
P29474 (NOS3) T495 Signor 24379783
P50613 (CDK7) T170 neXtProt   PhosphoSitePlus 22021906
P51617 (IRAK1) T66 neXtProt 14684752
Q13464 (ROCK1) T1024 neXtProt 21685893
Q13464 (ROCK1) S1333 neXtProt 21685893
Q13464 (ROCK1) T1334 neXtProt 21685893
Q13464 (ROCK1) T1337 neXtProt 21685893
Q13464 (ROCK1) S1341 neXtProt 21685893
Q14247 (CTTN) S261 PhosphoSitePlus 24753582
Q15334 (LLGL1) S659 neXtProt 12725730
Q6P1M3 (LLGL2) S653 neXtProt 12725730
Q6STE5 (SMARCD3) S247 PhosphoSitePlus 23219531
Q7KZI7 (MARK2) T596 neXtProt   PhosphoSitePlus 15084291, 15324659
Q8TEW0 (PARD3) S827 neXtProt 22579248
Q92934 (BAD) S75 neXtProt   PhosphoSitePlus   Signor 21419810, 15705582
Q92934 (BAD) S99 neXtProt   PhosphoSitePlus   Signor 21419810, 15705582
Q92934 (BAD) S118 neXtProt   PhosphoSitePlus   Signor 21419810, 15705582
Q969H0 (FBXW7) S10 PhosphoSitePlus 20815813
Q969H0 (FBXW7) S18 PhosphoSitePlus 20815813
Q9H8V3 (ECT2) T359 neXtProt   PhosphoSitePlus   Signor 21189248
Q9NPB6 (PARD6A) S345 PhosphoSitePlus 23249950
Q9UBS0 (RPS6KB2) S473 PhosphoSitePlus 12529391


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
P2 Q2 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S8 N8 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S11 T11 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K134 R134 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S246 A246 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S247 P247 Biomuta DOID:2394 / ovarian cancer [ tcga ]
S247 F247 Biomuta DOID:363 / uterine cancer [ tcga ]
Y265 * Biomuta DOID:9256 / colorectal cancer [ tcga ]
T410 I410 Biomuta DOID:2531 / hematologic cancer [ icgc ]
Y419 S419 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y430 C430 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y430 D430 Biomuta DOID:363 / uterine cancer [ tcga ]
S459 F459 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S459 P459 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S591 C591 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]