iPTMnet Report for P41235 (HNF4A)
Protein Information
| UniProt AC / UniProt ID | P41235 / HNF4A_HUMAN |
| Protein Name | Hepatocyte nuclear factor 4-alpha |
| Gene Name | Name: HNF4A Synonyms:HNF4,NR2A1,TCF14; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P41235 |
| PRO Name | hepatocyte nuclear factor 4-alpha (human) |
| Definition | A hepatocyte nuclear factor 4-alpha that is encoded in the genome of human. |
| Short Label | hHNF4A |
| Category | organism-gene |
DAG ViewP41235 (HNF4A) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Y23 | Phosphorylation | P12931 (SRC) | score3 | PhosphoSitePlus Signor | 22308320 | |
| Y72 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S75 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S76 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S95 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S99 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K106 | Acetylation | score1 | PhosphoSitePlus | |||
| K108 | Acetylation | score1 | PhosphoSitePlus | |||
| K126 | Acetylation | score1 | PhosphoSitePlus | |||
| K127 | Acetylation | score1 | PhosphoSitePlus | |||
| S138 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T139 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S142 | Phosphorylation | P17612 (PRKACA) | score4 | neXtProt phospho.ELM PhosphoSitePlus UniProt | 21708125, 16351573, 9234678 | |
| S143 | Phosphorylation | P17612 (PRKACA) | score4 | neXtProt phospho.ELM PhosphoSitePlus | 16351573, 9234678 | |
| Y144 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| S147 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S148 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S151 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T166 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 21708125 | ||
| S167 | Phosphorylation | Q16539 (MAPK14) , Q15759 (MAPK11) | score4 | neXtProt phospho.ELM PhosphoSitePlus UniProt | 21708125, 17317687, 16351573 | |
| S170 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S183 | Phosphorylation | score1 | IEDB | 35494241 | ||
| S190 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus | 16351573 | ||
| K234 | Ubiquitination | score3 | PhosphoSitePlus UniProt | 21708125 | ||
| S262 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S265 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y286 | Phosphorylation | P12931 (SRC) | score3 | PhosphoSitePlus Signor | 22308320 | |
| Y288 | Phosphorylation | P12931 (SRC) | score3 | PhosphoSitePlus Signor | 22308320 | |
| S303 | Phosphorylation | Q13131 (PRKAA1) | score3 | neXtProt PhosphoSitePlus Signor | 12740371 | |
| K307 | Ubiquitination | score3 | PhosphoSitePlus UniProt | 21708125 | ||
| K309 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S313 | Phosphorylation | Q13131 (PRKAA1) | score3 | phospho.ELM PhosphoSitePlus UniProt | 12740371 | |
| S318 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S378 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T429 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| T432 | Phosphorylation | score4 | PhosphoSitePlus UniProt | 21708125, 24275569 | ||
| S436 | Phosphorylation | score4 | PhosphoSitePlus UniProt | 21708125, 24275569 | ||
| S441 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S443 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T455 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K458 | Acetylation | score3 | PhosphoSitePlus UniProt | 21708125 | ||
| S461 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T467 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T469 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus | 16351573 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S167 | Phosphorylation | Q16539 (MAPK14) | score1 | HPRD | 16351573 | |
| S313 | Phosphorylation | P54646 (PRKAA2) | score1 | HPRD | 12740371 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S167 | Phosphorylation | Q16539 (MAPK14) | score1 | HPRD | 16351573 | |
| S313 | Phosphorylation | P54646 (PRKAA2) | score1 | HPRD | 12740371 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S145 | Phosphorylation | Q16539 (MAPK14) | score1 | HPRD | 16351573 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| Y72 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S75 | * | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ] | |
| T139 | I139 | Biomuta | [ cosmic ] | |
| S151 | Y151 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S170 | F170 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| S170 | C170 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| S190 | F190 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| Y286 | F286 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| S313 | F313 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| T429 | P429 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| T429 | I429 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| T432 | I432 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
| S443 | Y443 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| T467 | A467 | Biomuta | DOID:363 / uterine cancer [ icgc ] |
