Protein Information

Cytoscape View


UniProt AC / UniProt ID P41235 / HNF4A_HUMAN
Protein Name Hepatocyte nuclear factor 4-alpha
Gene Name Name: HNF4A
Synonyms:HNF4,NR2A1,TCF14;
Organism Homo sapiens (Human)

PRO ID PR:P41235
DAG View
PRO Name hepatocyte nuclear factor 4-alpha (human)
Definition A hepatocyte nuclear factor 4-alpha that is encoded in the genome of human.
Short Label hHNF4A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P41235 (HNF4A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y23 Phosphorylation PhosphoSitePlus   Signor 22308320
Y23 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 22308320
Y72 Phosphorylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
S99 Phosphorylation PhosphoSitePlus
K106 Acetylation PhosphoSitePlus
K108 Acetylation PhosphoSitePlus
K126 Acetylation PhosphoSitePlus
K127 Acetylation PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
T139 Phosphorylation PhosphoSitePlus
S142 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 21708125, 16351573, 9234678
S142 Phosphorylation P17612 (PRKACA) neXtProt 9234678
S143 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus 16351573, 9234678
S143 Phosphorylation P17612 (PRKACA) neXtProt 9234678
Y144 Phosphorylation PhosphoSitePlus   UniProt 24275569
S147 Phosphorylation PhosphoSitePlus
S148 Phosphorylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
T166 Phosphorylation PhosphoSitePlus   UniProt 21708125
S167 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 21708125, 17317687, 16351573
S167 Phosphorylation Q15759 (MAPK11) phospho.ELM   PhosphoSitePlus 16351573
S167 Phosphorylation Q16539 (MAPK14) neXtProt   PhosphoSitePlus 17317687, 16351573
S170 Phosphorylation PhosphoSitePlus
S183 Phosphorylation IEDB 35494241
S190 Phosphorylation phospho.ELM   PhosphoSitePlus 16351573
K234 Ubiquitination PhosphoSitePlus   UniProt 21708125
S262 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus
Y286 Phosphorylation PhosphoSitePlus   Signor 22308320
Y286 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 22308320
Y288 Phosphorylation PhosphoSitePlus   Signor 22308320
Y288 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 22308320
S303 Phosphorylation neXtProt   PhosphoSitePlus   Signor 12740371
S303 Phosphorylation Q13131 (PRKAA1) Signor 12740371
K307 Ubiquitination PhosphoSitePlus   UniProt 21708125
K309 Ubiquitination PhosphoSitePlus
S313 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 12740371
S313 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus 12740371
S318 Phosphorylation PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
T429 Phosphorylation PhosphoSitePlus   UniProt 24275569
T432 Phosphorylation PhosphoSitePlus   UniProt 21708125, 24275569
S436 Phosphorylation PhosphoSitePlus   UniProt 21708125, 24275569
S441 Phosphorylation PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
T455 Phosphorylation PhosphoSitePlus
K458 Acetylation PhosphoSitePlus   UniProt 21708125
S461 Phosphorylation PhosphoSitePlus
T467 Phosphorylation PhosphoSitePlus
T469 Phosphorylation phospho.ELM   PhosphoSitePlus 16351573
Site PTM Type PTM Enzyme Score Source PMID
S167 Phosphorylation HPRD 16351573
S167 Phosphorylation Q16539 (MAPK14) HPRD 16351573
S313 Phosphorylation HPRD 12740371
S313 Phosphorylation P54646 (PRKAA2) HPRD 12740371
Site PTM Type PTM Enzyme Score Source PMID
S167 Phosphorylation HPRD 16351573
S167 Phosphorylation Q16539 (MAPK14) HPRD 16351573
S313 Phosphorylation HPRD 12740371
S313 Phosphorylation P54646 (PRKAA2) HPRD 12740371
Site PTM Type PTM Enzyme Score Source PMID
S145 Phosphorylation HPRD 16351573
S145 Phosphorylation Q16539 (MAPK14) HPRD 16351573
Site PTM Type PTM Enzyme Score Source PMID
S145 Phosphorylation HPRD 16351573
S145 Phosphorylation Q16539 (MAPK14) HPRD 16351573
Site PTM Type PTM Enzyme Score Source PMID
S145 Phosphorylation HPRD 16351573
S145 Phosphorylation Q16539 (MAPK14) HPRD 16351573


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y72 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S75 * Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ]
T139 I139 Biomuta [ cosmic ]
S151 Y151 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S170 F170 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S170 C170 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S190 F190 Biomuta DOID:363 / uterine cancer [ icgc ]
Y286 F286 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S313 F313 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T429 P429 Biomuta DOID:4159 / skin cancer [ cosmic ]
T429 I429 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T432 I432 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S443 Y443 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T467 A467 Biomuta DOID:363 / uterine cancer [ icgc ]