iPTMnet Report for P40763 (STAT3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P40763 / STAT3_HUMAN
Protein Name Signal transducer and activator of transcription 3
Gene Name Name: STAT3
Synonyms:APRF;
Organism Homo sapiens (Human)

PRO ID PR:P40763
DAG View
PRO Name signal transducer and activator of transcription 3 (human)
Definition A signal transducer and activator of transcription 3 that is encoded in the genome of human.
Short Label hSTAT3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P40763 (STAT3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22223895
S25 Phosphorylation RLIMS-P 26175331
Y45 Phosphorylation PhosphoSitePlus   RLIMS-P 26384563
K49 Acetylation PhosphoSitePlus
K49 Methylation PhosphoSitePlus
Y68 Phosphorylation PhosphoSitePlus
Y79 Phosphorylation PhosphoSitePlus
K87 Acetylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
K163 Methylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
Y176 Phosphorylation PhosphoSitePlus
K177 Sumoylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
T196 Phosphorylation PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
T236 Phosphorylation PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
C328 Methylation IEDB 31844290
K348 Ubiquitination PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
K365 Ubiquitination PhosphoSitePlus
K370 Acetylation PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
K383 Acetylation PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus
T440 Phosphorylation PhosphoSitePlus
Y446 Phosphorylation PhosphoSitePlus
K451 Sumoylation PhosphoSitePlus
K495 Sumoylation PhosphoSitePlus
Y539 Phosphorylation PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus
K551 Ubiquitination PhosphoSitePlus
K574 Ubiquitination PhosphoSitePlus
K601 Acetylation UniProt 28065600
K601 Ubiquitination PhosphoSitePlus
T605 Phosphorylation PhosphoSitePlus
S611 Phosphorylation RLIMS-P 27835873
S613 Phosphorylation RLIMS-P 27835873
K615 Acetylation UniProt 28065600
K615 Ubiquitination PhosphoSitePlus
T622 Phosphorylation PhosphoSitePlus   RLIMS-P 35722967
K626 Ubiquitination PhosphoSitePlus
K631 Acetylation PhosphoSitePlus   UniProt 28065600
K631 Ubiquitination PhosphoSitePlus
T632 Phosphorylation PhosphoSitePlus
S636 Phosphorylation PhosphoSitePlus
Y640 Phosphorylation PhosphoSitePlus   RLIMS-P 29228628, 28284718, 29162862, ...24742922, 32231398
T641 Phosphorylation PhosphoSitePlus
K642 Ubiquitination PhosphoSitePlus
Y674 Phosphorylation PhosphoSitePlus
K679 Ubiquitination PhosphoSitePlus
K685 Acetylation PhosphoSitePlus   UniProt 28065600
K685 Ubiquitination PhosphoSitePlus
Y686 Phosphorylation PhosphoSitePlus
R688 Methylation PhosphoSitePlus
S691 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 17525332, 22279540
S701 Phosphorylation PhosphoSitePlus
P704 Phosphorylation UniProt 15592455, 24275569
Y705 Phosphorylation IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 30251272, 32922036, 28430601, ...30770798, 26430964, 17967179, 24058749, 25393367, 31068940, 27888804, 31575007, 28757590, 29660364, 29229958, 17575268, 21163886, 25661370, 19903761, 27871173, 29950561, 24622734, 27216197, 22359610, 31337063, 31655629, 32868906, 31878046, 24499623, 26452542, 23967200, 21486470, 29330478, 30209389, 32526010, 33469308, 25879763, 26549519, 29207614, 30455690, 31695791, 22351606, 28560454, 25622587, 23189171, 24505404, 28345832, 27602766, 23108098, 28903349, 24615012, 31847229, 26667266, 28157698, 23056515, 15527783, 31537377, 29774125, 25512602, 31455240, 24930769, 23831387, 28055016, 20169197, 33818016, 29904948, 28000790, 23782265, 24312439, 22484976, 29062282, 22870139, 31018021, 30123428, 31118769, 20371721, 11378264, 16849418, 27036022, 19764570, 33293765, 29228628, 23322008, 18498667, 27384401, 28783167, 27457246, 25968054, 29263930, 29402895, 27977009, 12670499, 25246098, 28785079, 11429593, 24687132, 9531474, 21690253, 29050232, 23279849, 19821497, 23350355, 28367059, 16455651, 23326583, 10446219, 21253577, 26279438, 32721246, 29464030, 25013907, 25047660, 29540666, 28280036, 22465052, 23889739, 19712481, 31709178, 22280969, 28503147, 36179418, 31568643, 21915376, 17173857, 28500786, 24090995, 24319264, 29190960, 26084289, 31990532, 32850477, 21840932, 11777539, 25452693, 29805309, 24520293, 14963038, 22259633, 17202361, 23372833, 18463684, 30009856, 28397855, 22179221, 24058783, 33174044, 30375708, 25327561, 9083098, 28676732, 27462789, 21685938, 26343524, 17311011, 29686295, 27419630, 20977777, 24280348, 31277685, 30980700, 27317770, 29234062, 26956050, 32242230, 24324713, 30214513, 30947697, 27626315, 23094050, 16384639, 26610526, 22754353, 24652192, 32252311, 22899991, 21254404, 21098725, 25561562, 28884137, 27845909, 18755267, 15174071, 30674340, 26283544, 29174507, 26486080, 27624867, 23756865, 21538419, 25031733, 32054489, 29637003, 29142074, 15705894, 32182833, 24129709, 16619044, 26898989, 33658640, 32863764, 23991099, 25928665, 23936533, 23690956, 23528817, 32811873, 20228845, 26909608, 29499951, 22349830, 30261753, 24586249, 20507639, 23947369, 19754877, 21654841, 27009358, 27121055, 31409371, 28134252, 22306293, 31277507, 26904942, 28138036, 32483468, 28350008, 25072782, 21738667, 25699542, 25231320, 16846476, 31888532, 21311975, 33277798, 29024195, 27502076, 27748818, 19232485, 15864742, 24954857, 29518696, 24533098, 21954831, 17237271, 28781685, 16951338, 32973302, 18525315, 28588262, 31205408, 32475380, 31226168, 29088733, 26028030, 11553624, 20156552, 24707243, 28388577, 16669628, 18755494, 16150460, 28636670, 22174695, 23923048, 24661007, 19903771, 17432718, 28881473, 22937084, 28157205, 33193827, 26041409, 31448054, 24317090, 12494267, 31383893, 23440042, 23125416, 30080291, 22905257, 32051479, 30948493, 27616044, 26329521, 22799634, 26799670, 35566660, 30622543, 32751884, 10845908, 27687804, 31048139, 26175331, 23446809, 33164240, 18941632, 18995957, 27806334, 11850821, 31337349, 23903834, 20877211, 33291686, 30106087, 28384648, 30760703, 29807795, 30986607, 25789077, 25849286, 29126425, 25252914, 26807955, 30323565, 28276425, 30442941, 15753368, 30783489, 27486258, 30135654, 22987802, 28750624, 26959890, 32005799, 31920333, 32071920, 32365859, 22461519, 35476936, 26883202, 27418138, 29270528, 27151455, 30127373, 29423098, 19421230, 27326257, 30675525, 24970801, 25605239, 32972460, 29749438, 31938049, 22110204, 24799285, 32716315, 12244095, 13678425, 31306849, 29595328, 33217668, 31182137, 29682112, 28054649, 20851386, 22920439, 33101052, 31816634, 12474230, 19147545, 29449694, 25744297, 28483518, 28720093, 28785380, 26459366, 30720080, 17670892, 25597412, 24348829, 26008966, 25216529, 25539644, 28228214, 19159681, 31227842, 26755645, 34067421, 24048798, 24671465, 31422383, 16247467, 8662591, 28654902, 26485029, 21435102, 33517393, 29606890, 18083107, 30234199, 29082496, 31500219, 35809767, 30857539, 29179471, 31129031, 28223425, 30854231, 28705432, 30015159, 32735617, 30286779, 26700461, 32391256, 19304789, 9305919, 25217, 25881314, 15592455, 26657118, 25811798, 32852592, 30756445, 19440292, 21741923, 24736071, 31438472, 33541421, 28634059, 28150717, 33920736, 19723038, 26293184, 27537522, 24726840, 29630659, 30127519, 29158850, 24275569, 12763138, 33053804, 32929201, 28469272, 24931163, 30720090, 7510216, 30981183, 32587662, 33178223, 30250641, 33040485, 31908417, 26068861, 22366233, 32807795, 33038372, 33391507, 25915430, 33257655, 25200966, 12637586, 32667731, 26418031, 31530281, 14551213, 25883212, 26166037, 26090459, 16568091, 10918587, 9575217, 26215634, 31956373, 21135090, 27660268, 29180818, 16464493, 32491253, 28492557, 31899195, 23776396, 10878010, 20455003, 9582023, 29652915
Y705 Phosphorylation O60674 (JAK2) phospho.ELM   PhosphoSitePlus   Signor 9575217, 9582023, 16464493
Y705 Phosphorylation P12931 (SRC) Signor 14551213
Y705 Phosphorylation P14618 (PKM) PhosphoSitePlus   Signor 22306293
Y705 Phosphorylation P16591 (FER) neXtProt   PhosphoSitePlus 19147545, 19159681, 10878010
Y705 Phosphorylation P22455 (FGFR4) Signor 10918587
Y705 Phosphorylation P22607 (FGFR3) Signor 10918587
Y705 Phosphorylation P23458 (JAK1) Signor 19723038
Y705 Phosphorylation P27361 (MAPK3) Signor 14551213, 19723038
Y705 Phosphorylation Q13882 (PTK6) neXtProt 21741923, 19304789
Y705 Phosphorylation Q15300 (RET/PTC2) PhosphoSitePlus   Signor 12637586
Y705 Phosphorylation Q9UM73 (ALK) phospho.ELM   PhosphoSitePlus 11850821
K707 Acetylation UniProt 28065600
K707 Ubiquitination PhosphoSitePlus
T708 Phosphorylation PhosphoSitePlus
C712 Methylation IEDB 31844290
T714 O-Glycosylation GlyGen 23301498, 33214551, 30205382, ...22661428, 30397120, 30379171, 32574038, 34725712, 30059200, 29351928, 34391182, 34019948, 35083852, 35289036, 35254053, 28657654
T714 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 22279540, 24275569
T716 O-Glycosylation GlyGen 23301498, 33214551, 32938750, ...30205382, 22661428, 30397120, 30379171, 32574038, 34725712, 30059200, 29351928, 34391182, 34019948, 35083852, 35289036, 35254053, 28657654
T717 O-Glycosylation GlyGen 23301498, 33214551, 32938750, ...30205382, 22661428, 30397120, 30379171, 32574038, 34725712, 30059200, 29351928, 34391182, 34019948, 35083852, 35289036, 35254053, 28657654
T717 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 35131454, 18669648, 22279540, ...28280036
S719 O-Glycosylation GlyGen 23301498, 33214551, 32938750, ...30205382, 22661428, 30397120, 30379171, 32574038, 34725712, 30059200, 29351928, 34391182, 34019948, 35083852, 35289036, 35254053, 28657654
S719 Phosphorylation PhosphoSitePlus   RLIMS-P 22279540
T721 O-Glycosylation GlyGen 23301498, 33214551, 30205382, ...22661428, 30397120, 30379171, 32574038, 34725712, 30059200, 29351928, 34391182, 34019948, 35083852, 35289036, 35254053, 28657654
T721 Phosphorylation PhosphoSitePlus
S727 O-Glycosylation GlyGen 23301498, 33214551, 30205382, ...22661428, 30397120, 30379171, 32574038, 34725712, 30059200, 29351928, 34391182, 34019948, 35083852, 35289036, 35254053, 28657654
S727 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 26430964, 25393367, 17575268, ...19764570, 16418226, 28130399, 25153725, 31655629, 33791043, 31878046, 24499623, 29330478, 25375189, 26799670, 27806334, 15527783, 29774125, 25512602, 23831387, 33818016, 23255093, 18939993, 23782265, 24312439, 23704922, 30846988, 22870139, 22696236, 32171124, 29683208, 21619877, 31780735, 17543278, 19429262, 29212252, 28783167, 25968054, 29263930, 11071637, 31980595, 29636527, 24496235, 10446219, 21253577, 26636769, 22581330, 29464030, 25013907, 25047660, 18599021, 28280036, 22280969, 21915376, 10521505, 24090995, 31899195, 29190960, 22689141, 35125963, 10336453, 25452693, 10727406, 29652915, 29805309, 12748293, 14963038, 20871632, 18499896, 18463684, 33782423, 20979115, 28397855, 22179221, 30375708, 23329648, 30263097, 17311011, 29686295, 20977777, 36017196, 18691976, 35928250, 26028030, 20686606, 18755267, 18668152, 23329839, 11150545, 17027757, 21538419, 25031733, 11429693, 29082496, 22791907, 31817563, 26898989, 32231398, 20228845, 34543857, 22349830, 27824155, 23947369, 30470788, 28134252, 31304451, 28350008, 22393233, 9343414, 35031324, 25383546, 21398617, 27502076, 24954857, 15864742, 33002501, 24533098, 21954831, 17237271, 16951338, 32973302, 18525315, 31205408, 25789853, 31226168, 29088733, 11553624, 20156552, 16669628, 26911335, 22174695, 16720575, 33429003, 31013746, 27185663, 12494267, 31611552, 23125416, 21159613, 22905257, 30948493, 27616044, 35566660, 12562765, 10845908, 31048139, 26175331, 18995957, 32390009, 18448488, 20877211, 28384648, 26792726, 32792856, 25252914, 34908808, 30442941, 20068231, 30783489, 23690956, 26959890, 28640256, 15004007, 29270528, 30127373, 17703129, 29423098, 30675525, 25605239, 32972460, 28086195, 22110204, 24799285, 32807795, 32716315, 29595328, 33217668, 26042668, 22920439, 17258468, 29449694, 25744297, 31681292, 9399961, 29995595, 19440292, 29518129, 18669648, 17502367, 24726840, 31227842, 16247467, 26485029, 11556393, 30687322, 30234199, 29379494, 24487064, 27458171, 16801397, 36443287, 26593962, 25740948, 31284599, 31817171, 25762897, 15764709, 33262462, 32767999, 26359029, 29309895, 26055806, 21677772, 24086526, 27064016, 12474230, 30410767, 21906308, 33692335, 28515148, 32735617, 30286779, 30123428, 26918609, 21783819, 28004755, 16879821, 17875724, 25854938, 26657118, 19875458, 25089666, 15155836, 33066004, 32005799, 24283803, 32377705, 19182994, 20473906, 31760402, 26843613, 32319563, 17931419, 11335711, 19723038, 24069562, 26293184, 32060308, 31025789, 32797246, 29630659, 27918421, 12796477, 28160777, 10537060, 33529218, 28670112, 11470914, 29666362, 27447722, 19121623, 27127727, 17145757, 10878008, 29158850, 24275569, 24423131, 12763138, 27242913, 26904961, 16219639, 30616203, 19427337, 18198175, 23941877, 9322921, 32636937, 28469272, 21702955, 28035720, 33772065, 27708408, 24931163, 20516069, 17563747, 25226283, 33279931, 27840601, 26921179, 28415760, 16846476, 26376676, 33040485, 32565533, 24703937, 17993646, 23379788, 22922995, 31319869, 35670018, 26791143, 27748760, 27080861, 30610554, 18550668, 18519681, 36103247, 23455323, 26949510, 29456240, 18483256, 29488000, 15465816, 21625597, 15115615, 11322950, 24671708, 24288470, 14999683, 15096606, 34440160, 30036966, 16401721, 33098871, 11278353, 33061855, 18829527, 28157712, 27050371, 27658964, 16048438, 25736961, 33660414, 31530281, 15994929, 33640759, 31198634, 25584415, 18365011, 14551213, 22279540, 16740698, 23740979, 30728072, 20712901, 26045618, 28574510, 26575169, 11350938, 28150703, 23226414, 16425286, 25642823, 23352233, 24728078, 31500219, 33357429, 31956373, 19885032, 21135090, 27660268, 25299776, 17341659, 24086494, 30323145, 18204781, 23186163, 25360179, 27145367, 33968084, 31337843, 12130710, 32491253, 28030813, 24058772, 15467762, 25280942, 32304779, 21801384, 26664907, 19901082, 30302278, 36282975, 22142222, 18037959, 28881473, 23614738, 18196976, 24469975, 22937084, 15522880, 20154216, 10660304, 24667661, 29604049, 25544757, 23928694, 22418867, 32774719, 29050266, 25116684, 20595392, 11922392, 28350087, 28542650, 29949238, 16651438, 33446662, 24886617, 21878628, 16288304, 31398350, 21490133, 29571296
S727 Phosphorylation O43293 (DAPK3) neXtProt 16219639
S727 Phosphorylation O75582 (RPS6KA5) neXtProt   Signor 12763138
S727 Phosphorylation P06493 (CDK1) RLIMS-P+ 16669628
S727 Phosphorylation P27361 (MAPK3) RLIMS-P+   Signor 14551213, 19723038, 25584415
S727 Phosphorylation P28482 (MAPK1) RLIMS-P+ 25584415
S727 Phosphorylation P42345 (MTOR) Signor 18691976, 16740698
S727 Phosphorylation P45983 (MAPK8) neXtProt   PhosphoSitePlus   Signor 10521505, 23255093, 12562765
S727 Phosphorylation P45984-2 (MAPK9) neXtProt   PhosphoSitePlus   Signor 18691976, 20871632
S727 Phosphorylation P51617 (IRAK1) phospho.ELM   PhosphoSitePlus   Signor 15465816
S727 Phosphorylation P51812 (RPS6KA3) PhosphoSitePlus 12562765
S727 Phosphorylation Q00535 (CDK5) PhosphoSitePlus   RLIMS-P+   Signor 15096606, 23941877, 20516069
S727 Phosphorylation Q02156 (PRKCE) neXtProt   PhosphoSitePlus   Signor 16418226, 20228845, 17875724
S727 Phosphorylation Q05655 (PRKCD) PhosphoSitePlus   Signor 16951338, 16418226
S727 Phosphorylation Q13233 (MAP3K1) Signor 17563747
S727 Phosphorylation Q13555 (CAMK2G) neXtProt 18483256
S727 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus   Signor 18691976, 12748293, 17502367
S727 Phosphorylation Q9HC98 (NEK6) neXtProt   PhosphoSitePlus 20595392
S727 Phosphorylation Q9UBE8 (NLK) neXtProt   Signor 17563747, 15764709, 15004007
S754 Phosphorylation RLIMS-P 28188292, 32404352
Site PTM Type PTM Enzyme Score Source PMID
Y539 Phosphorylation HPRD 19901323
Y657 Phosphorylation HPRD 15037656
Y674 Phosphorylation HPRD 15037656
K685 Acetylation PRO 15653507, 19506034
K685 Acetylation PR:Q09472 (hEP300) PRO 15653507, 19506034
Y686 Phosphorylation HPRD 17016520, 16497976
S691 Phosphorylation HPRD 17525332
Y705 Phosphorylation HPRD 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095, 16497976
Y705 Phosphorylation O60674 (JAK2) HPRD 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095, 16497976
Y705 Phosphorylation P08631 (HCK) HPRD 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095, 16497976
Y705 Phosphorylation P12931 (SRC) HPRD 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095, 16497976
Y705 Phosphorylation P22455 (FGFR4) HPRD 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095, 16497976
Y705 Phosphorylation P22607 (FGFR3) HPRD 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095, 16497976
Y705 Phosphorylation P23458 (JAK1) HPRD 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095, 16497976
Y705 Phosphorylation P29320 (EPHA3) HPRD 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095, 16497976
T714 Phosphorylation HPRD 18691976, 18669648
T717 Phosphorylation HPRD 18669648
S727 Phosphorylation HPRD 19413330, 18691976, 12763138, ...10446219, 12576423, 20058876, 11350938, 9872331, 10521505, 18669648, 18491316, 14551213, 20068231, 9343414
S727 Phosphorylation O75582 (RPS6KA5) HPRD 19413330, 18691976, 12763138, ...10446219, 12576423, 20058876, 11350938, 9872331, 10521505, 18669648, 18491316, 14551213, 20068231, 9343414
S727 Phosphorylation P27361 (MAPK3) HPRD 19413330, 18691976, 12763138, ...10446219, 12576423, 20058876, 11350938, 9872331, 10521505, 18669648, 18491316, 14551213, 20068231, 9343414
S727 Phosphorylation P28482 (MAPK1) HPRD 19413330, 18691976, 12763138, ...10446219, 12576423, 20058876, 11350938, 9872331, 10521505, 18669648, 18491316, 14551213, 20068231, 9343414
S727 Phosphorylation P45983 (MAPK8) HPRD 19413330, 18691976, 12763138, ...10446219, 12576423, 20058876, 11350938, 9872331, 10521505, 18669648, 18491316, 14551213, 20068231, 9343414
S727 Phosphorylation Q05655 (PRKCD) HPRD 19413330, 18691976, 12763138, ...10446219, 12576423, 20058876, 11350938, 9872331, 10521505, 18669648, 18491316, 14551213, 20068231, 9343414
Site PTM Type PTM Enzyme Score Source PMID
Y539 Phosphorylation HPRD   PhosphoSitePlus 19901323
K685 Ubiquitination PhosphoSitePlus
S691 Phosphorylation PhosphoSitePlus
Y704 Phosphorylation HPRD   PhosphoSitePlus 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095
Y704 Phosphorylation O60674 (JAK2) HPRD 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095
Y704 Phosphorylation P08631 (HCK) HPRD 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095
Y704 Phosphorylation P12931 (SRC) HPRD 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095
Y704 Phosphorylation P22455 (FGFR4) HPRD 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095
Y704 Phosphorylation P22607 (FGFR3) HPRD 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095
Y704 Phosphorylation P23458 (JAK1) HPRD 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095
K706 Ubiquitination PhosphoSitePlus
T707 Phosphorylation PhosphoSitePlus
T713 Phosphorylation HPRD   PhosphoSitePlus 18691976, 18669648
T716 Phosphorylation HPRD 18669648
S726 Phosphorylation HPRD 19413330, 18691976, 12763138, ...9343414, 12576423, 20058876, 11350938, 9872331, 10521505, 18669648, 18491316, 14551213, 20068231
S726 Phosphorylation O75582 (RPS6KA5) HPRD 19413330, 18691976, 12763138, ...9343414, 12576423, 20058876, 11350938, 9872331, 10521505, 18669648, 18491316, 14551213, 20068231
S726 Phosphorylation P27361 (MAPK3) HPRD 19413330, 18691976, 12763138, ...9343414, 12576423, 20058876, 11350938, 9872331, 10521505, 18669648, 18491316, 14551213, 20068231
S726 Phosphorylation P28482 (MAPK1) HPRD 19413330, 18691976, 12763138, ...9343414, 12576423, 20058876, 11350938, 9872331, 10521505, 18669648, 18491316, 14551213, 20068231
S726 Phosphorylation P45983 (MAPK8) HPRD 19413330, 18691976, 12763138, ...9343414, 12576423, 20058876, 11350938, 9872331, 10521505, 18669648, 18491316, 14551213, 20068231
S726 Phosphorylation Q05655 (PRKCD) HPRD 19413330, 18691976, 12763138, ...9343414, 12576423, 20058876, 11350938, 9872331, 10521505, 18669648, 18491316, 14551213, 20068231
Site PTM Type PTM Enzyme Score Source PMID
Y539 Phosphorylation HPRD 19901323
Y686 Phosphorylation HPRD 17016520, 16497976
S691 Phosphorylation HPRD 17525332
Y705 Phosphorylation HPRD   PhosphoSitePlus 17016520, 10918587, 12576423, ...8626374, 11350938, 14551213, 17389395, 19901323, 12626508, 11294897, 11940572, 12244095, 16497976
Y705 Phosphorylation O60674 (JAK2) HPRD 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095, 16497976
Y705 Phosphorylation P29320 (EPHA3) HPRD 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095, 16497976


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000027924 (hSTAT3/iso:1/Ac:1) acK685 PR:Q09472 (hEP300) PRO 15653507, 19506034


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O15162 (PLSCR1) Y74 P40763 (STAT3) increased_association eFIP 32292520
Phosphorylation P40763 (STAT3) S727 P10275 (AR) unknown eFIP 30470788
Phosphorylation P40763 (STAT3) Y705 inhibited_association eFIP 23125416
Phosphorylation P40763 (STAT3) Y705 Q9QXD6 (Fbp1) decreased_association eFIP 31938049
Phosphorylation P40763 (STAT3) S727 P15692 (VEGFA) unknown eFIP 22696236
Phosphorylation P40763 (STAT3) Y705 Q9Y2H2 (INPP5F) unknown eFIP 25476455
Phosphorylation P40763 (STAT3) Y705 O43474 (KLF4) unknown eFIP 24129709
Phosphorylation P40763 (STAT3) Y705 P19838 (NFKB1) unknown eFIP 33420372
Phosphorylation P40763 (STAT3) Y705 P40763 (STAT3) unknown eFIP 26898989
Phosphorylation P40763 (STAT3) S727 P10275 (AR) unknown eFIP 23941877
Phosphorylation P40763 (STAT3) Y705 P05231 (IL6) unknown eFIP 22280969


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y686 D686 Biomuta DOID:363 / uterine cancer [ icgc ]
Y686 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S691 C691 Biomuta DOID:3571 / liver cancer [ cosmic ]