Protein Information

Cytoscape View


UniProt AC / UniProt ID P40763 / STAT3_HUMAN
Protein Name Signal transducer and activator of transcription 3
Gene Name Name: STAT3
Synonyms:APRF;
Organism Homo sapiens (Human)

PRO ID PR:P40763
DAG View
PRO Name signal transducer and activator of transcription 3 (human)
Definition A signal transducer and activator of transcription 3 that is encoded in the genome of human.
Short Label hSTAT3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P40763 (STAT3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22223895
Y14 Phosphorylation RLIMS-P 29531159
S25 Phosphorylation RLIMS-P 26175331
Y45 Phosphorylation PhosphoSitePlus   RLIMS-P 26384563, 29531159
K49 Acetylation PhosphoSitePlus
K49 Methylation PhosphoSitePlus
Y68 Phosphorylation PhosphoSitePlus   RLIMS-P 29531159
Y79 Phosphorylation PhosphoSitePlus
K87 Acetylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
Y176 Phosphorylation PhosphoSitePlus
K177 Sumoylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
T196 Phosphorylation PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
T236 Phosphorylation PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
K363 Ubiquitination PhosphoSitePlus
K365 Ubiquitination PhosphoSitePlus
K370 Acetylation PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
K383 Acetylation PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus
T440 Phosphorylation PhosphoSitePlus
Y446 Phosphorylation PhosphoSitePlus
K451 Sumoylation PhosphoSitePlus
K495 Sumoylation PhosphoSitePlus
Y539 Phosphorylation PhosphoSitePlus
S540 Phosphorylation PhosphoSitePlus
K551 Ubiquitination PhosphoSitePlus
K574 Ubiquitination PhosphoSitePlus
K601 Acetylation UniProt 28065600
K601 Ubiquitination PhosphoSitePlus
T605 Phosphorylation PhosphoSitePlus
S611 Phosphorylation RLIMS-P 27835873
S613 Phosphorylation RLIMS-P 27835873
K615 Acetylation UniProt 28065600
K615 Ubiquitination PhosphoSitePlus
K626 Ubiquitination PhosphoSitePlus
K631 Acetylation PhosphoSitePlus   UniProt 28065600
K631 Ubiquitination PhosphoSitePlus
T632 Phosphorylation PhosphoSitePlus
S636 Phosphorylation PhosphoSitePlus
Y640 Phosphorylation PhosphoSitePlus   RLIMS-P 29228628, 28284718, 29162862, ...24742922, 32231398
T641 Phosphorylation PhosphoSitePlus
K642 Ubiquitination PhosphoSitePlus
Y674 Phosphorylation PhosphoSitePlus
K679 Ubiquitination PhosphoSitePlus
K685 Acetylation PhosphoSitePlus   UniProt 28065600
K685 Ubiquitination PhosphoSitePlus
Y686 Phosphorylation PhosphoSitePlus
S691 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 17525332, 22279540
S701 Phosphorylation PhosphoSitePlus
Y705 Phosphorylation O60674 (JAK2) , Q15300 (RET/PTC2) , P23458 (JAK1) , P22455 (FGFR4) , Q13882 (PTK6) , P22607 (FGFR3) , Q9UM73 (ALK) , P14618 (PKM) , P16591 (FER) , P12931 (SRC) , P27361 (MAPK3) IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 30251272, 32922036, 28430601, ...30770798, 26430964, 17967179, 24058749, 25393367, 31068940, 27888804, 31575007, 28757590, 29660364, 29229958, 17575268, 21163886, 25661370, 19903761, 27871173, 29950561, 24622734, 29079839, 27216197, 22359610, 31337063, 31655629, 32868906, 31878046, 25327561, 26452542, 23967200, 21486470, 29330478, 30209389, 32526010, 25879763, 26549519, 29207614, 30455690, 31695791, 22351606, 28560454, 24093616, 25622587, 23189171, 24505404, 28345832, 27602766, 23108098, 28903349, 24615012, 31847229, 26667266, 26799670, 23056515, 15527783, 31537377, 29774125, 25512602, 31455240, 24930769, 23831387, 28055016, 20169197, 33818016, 32025217, 29904948, 28000790, 23782265, 24312439, 22484976, 33298620, 29062282, 22870139, 31018021, 30123428, 31118769, 20371721, 11378264, 16849418, 27036022, 19764570, 33293765, 29228628, 23322008, 18498667, 27384401, 28783167, 27457246, 26755, 25968054, 29263930, 29402895, 27977009, 12670499, 25246098, 33774344, 28785079, 11429593, 24687132, 9531474, 21690253, 29050232, 23279849, 19821497, 23350355, 28367059, 16455651, 32377721, 23326583, 31631580, 10446219, 21253577, 26279438, 32721246, 29464030, 25013907, 25047660, 29540666, 28280036, 22465052, 23889739, 19712481, 31709178, 22280969, 28503147, 31427441, 9575217, 31568643, 21915376, 17173857, 28500786, 24090995, 31899195, 29190960, 26084289, 31990532, 32850477, 21840932, 31924750, 11777539, 25452693, 29805309, 24520293, 14963038, 22259633, 17202361, 23372833, 18463684, 30009856, 23434585, 28397855, 22179221, 24058783, 33174044, 30375708, 24499623, 9083098, 28676732, 27462789, 21685938, 26343524, 33369280, 17311011, 27430527, 29686295, 27419630, 20977777, 24280348, 31277685, 30980700, 27317770, 29234062, 26956050, 32242230, 24324713, 30214513, 30947697, 27626315, 23094050, 16384639, 26610526, 22754353, 24652192, 32252311, 22899991, 21254404, 21098725, 25561562, 28884137, 27845909, 18755267, 15174071, 28588262, 26283544, 29174507, 26486080, 25200966, 23756865, 21538419, 25031733, 29637003, 29142074, 15705894, 32182833, 24129709, 16619044, 26898989, 33658640, 32863764, 23991099, 25928665, 23936533, 23690956, 23528817, 32183406, 32144852, 20228845, 26909608, 29499951, 22349830, 30261753, 24586249, 20507639, 19754877, 21654841, 27009358, 27121055, 31409371, 28134252, 33834359, 22306293, 31277507, 26904942, 28138036, 28350008, 31958364, 32286285, 21738667, 25699542, 25231320, 16846476, 31888532, 21311975, 33277798, 29024195, 27502076, 27748818, 19232485, 15864742, 24533098, 21954831, 17237271, 28781685, 16951338, 32973302, 18525315, 31205408, 32475380, 31226168, 29088733, 26028030, 11553624, 20156552, 24707243, 28388577, 16669628, 18755494, 16150460, 28636670, 22174695, 23923048, 24661007, 17432718, 28881473, 22937084, 28157205, 33193827, 26041409, 31448054, 24317090, 12494267, 31383893, 23440042, 31315045, 30080291, 22905257, 32312954, 32051479, 30948493, 27616044, 26329521, 30953001, 32697823, 33414415, 30622543, 32751884, 10845908, 27687804, 31048139, 26175331, 23446809, 30981183, 33164240, 18941632, 18995957, 27806334, 11850821, 31337349, 23903834, 20877211, 28157698, 33291686, 30106087, 28384648, 30760703, 29807795, 30986607, 25789077, 25849286, 28445952, 29126425, 25252914, 26807955, 30323565, 28276425, 30442941, 15753368, 30783489, 27486258, 30135654, 22987802, 28750624, 26959890, 23947369, 31920333, 29254203, 32075387, 32071920, 32365859, 31982491, 22461519, 27418138, 29270528, 27151455, 30127373, 29423098, 19421230, 27326257, 30675525, 24970801, 25605239, 32972460, 29749438, 31938049, 22110204, 24799285, 17670892, 12244095, 13678425, 27624867, 8662591, 29595328, 33217668, 31182137, 29682112, 28054649, 20851386, 33374980, 22920439, 19903771, 12474230, 19147545, 26166037, 25744297, 28483518, 28720093, 28785380, 33413536, 26459366, 30720080, 32716315, 25597412, 24348829, 26008966, 25216529, 30659097, 25539644, 28228214, 19159681, 31227842, 31306849, 21435102, 18083107, 30234199, 29082496, 31500219, 30857539, 29179471, 31129031, 28223425, 30854231, 28705432, 30015159, 32735617, 30286779, 26700461, 32391256, 19304789, 9305919, 25881314, 15592455, 26657118, 25811798, 32852592, 31252559, 30756445, 21741923, 24736071, 33541421, 28634059, 28150717, 19723038, 26293184, 27537522, 24726840, 29630659, 29158850, 24275569, 12763138, 33053804, 33528916, 29568932, 28469272, 25072782, 33859760, 30720090, 7510216, 30674340, 32587662, 33178223, 30250641, 26068861, 22366233, 32807795, 33038372, 33391507, 24954857, 12637586, 33640759, 31530281, 22799634, 14551213, 25883212, 26090459, 16568091, 10918587, 26215634, 31956373, 21135090, 27660268, 29180818, 16464493, 32491253, 28492557, 24319264, 23776396, 10878010, 20455003, 9582023, 30950039, 29652915, 23125416
K707 Acetylation UniProt 28065600
K707 Ubiquitination PhosphoSitePlus
T708 Phosphorylation PhosphoSitePlus
T714 O-Glycosylation GlyGen 23301498, 30205382, 30397120, ...30059200, 29351928, 22661428, 28657654
T714 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 22279540, 24275569
T716 O-Glycosylation GlyGen 23301498, 30205382, 30397120, ...30059200, 29351928, 22661428, 28657654
T717 O-Glycosylation GlyGen 23301498, 30205382, 30397120, ...30059200, 29351928, 22661428, 28657654
T717 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 22279540, 28280036
S719 O-Glycosylation GlyGen 23301498, 30205382, 30397120, ...30059200, 29351928, 22661428, 28657654
S719 Phosphorylation PhosphoSitePlus   RLIMS-P 22279540
T721 O-Glycosylation GlyGen 23301498, 30205382, 30397120, ...30059200, 29351928, 22661428, 28657654
T721 Phosphorylation PhosphoSitePlus
S727 O-Glycosylation GlyGen 23301498, 30205382, 30397120, ...30059200, 29351928, 22661428, 28657654
S727 Phosphorylation Q02156 (PRKCE) , P51812 (RPS6KA3) , P45984 (MAPK9) , O75582 (RPS6KA5) , P28482 (MAPK1) , Q13555 (CAMK2G) , O43293 (DAPK3) , P42345 (MTOR) , P27361 (MAPK3) , P45983 (MAPK8) , P51617 (IRAK1) , Q16539 (MAPK14) , Q05655 (PRKCD) , Q9UBE8 (NLK) , P06493 (CDK1) , Q00535 (CDK5) , Q13233 (MAP3K1) , Q9HC98 (NEK6) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 26430964, 25393367, 31981230, ...17575268, 19764570, 16418226, 28130399, 25153725, 31655629, 33791043, 31878046, 24499623, 29330478, 25375189, 26799670, 27806334, 15527783, 29774125, 25512602, 33284859, 23831387, 33818016, 23255093, 18939993, 23782265, 24312439, 23704922, 30846988, 22870139, 22696236, 32171124, 29683208, 21619877, 31780735, 17543278, 19429262, 29212252, 28783167, 25968054, 29263930, 33813002, 11071637, 31980595, 33279931, 24496235, 32377721, 10446219, 21253577, 26636769, 22581330, 29464030, 25013907, 25047660, 18599021, 31530281, 22280969, 21915376, 10521505, 24090995, 31899195, 29190960, 22689141, 10336453, 25452693, 10727406, 29652915, 29805309, 12748293, 14963038, 20871632, 30242894, 18499896, 18463684, 33782423, 20979115, 28397855, 22179221, 30375708, 23329648, 30263097, 17311011, 29686295, 20977777, 29636527, 18691976, 26028030, 20686606, 18755267, 18668152, 23329839, 11150545, 19885032, 17027757, 21538419, 25031733, 11429693, 29082496, 22791907, 31817563, 26898989, 32144852, 32231398, 20228845, 22349830, 27824155, 28351946, 23947369, 30470788, 28134252, 31304451, 28350008, 22393233, 33639070, 25383546, 21398617, 27502076, 24954857, 15864742, 33002501, 24533098, 21954831, 17237271, 16951338, 32973302, 18525315, 31205408, 25789853, 31226168, 29088733, 11553624, 20156552, 16669628, 26911335, 22174695, 16720575, 33429003, 31013746, 27185663, 12494267, 31611552, 23125416, 21159613, 22905257, 30948493, 27616044, 33414415, 12562765, 10845908, 31048139, 26175331, 18995957, 32390009, 18448488, 20877211, 28384648, 26792726, 32792856, 28445952, 25252914, 30442941, 20068231, 30783489, 23690956, 28640256, 15004007, 29270528, 30127373, 17703129, 29423098, 30675525, 25605239, 32972460, 22110204, 24799285, 32807795, 32716315, 29595328, 33217668, 26042668, 22920439, 17258468, 29449694, 25744297, 31681292, 9399961, 29995595, 29518129, 18669648, 17502367, 24726840, 31227842, 33923020, 16247467, 26485029, 11556393, 30687322, 30234199, 29379494, 32298693, 24487064, 27458171, 23740979, 26593962, 25740948, 31284599, 31817171, 25762897, 15764709, 33262462, 32767999, 26359029, 31252559, 27835873, 26055806, 21677772, 24086526, 27064016, 12474230, 30410767, 21906308, 33692335, 28515148, 32735617, 30286779, 30123428, 26918609, 21783819, 28004755, 16879821, 17875724, 25854938, 26657118, 19875458, 25089666, 17209045, 15155836, 22142222, 24283803, 32377705, 19182994, 20473906, 31760402, 26843613, 32319563, 17931419, 11335711, 19723038, 24069562, 26293184, 32060308, 31025789, 32797246, 29630659, 27918421, 12796477, 28160777, 10537060, 33529218, 28670112, 11470914, 29666362, 27447722, 19121623, 27127727, 17145757, 10878008, 29158850, 15467762, 24423131, 12763138, 27242913, 26904961, 16219639, 30616203, 19427337, 18198175, 23941877, 9322921, 28469272, 21702955, 28035720, 33772065, 27708408, 33859760, 24931163, 30428347, 20516069, 17563747, 25226283, 31498440, 27840601, 26921179, 28322925, 28415760, 24260381, 16846476, 26376676, 32565533, 24703937, 17993646, 31678681, 23379788, 22922995, 31319869, 26791143, 27748760, 27080861, 30610554, 18550668, 18519681, 23455323, 26949510, 29456240, 18483256, 29488000, 15465816, 21625597, 33327495, 15115615, 11322950, 32308756, 24288470, 24655440, 14999683, 15096606, 30036966, 16401721, 33098871, 11278353, 33061855, 18829527, 28157712, 27050371, 27658964, 16048438, 25736961, 33660414, 28280036, 15994929, 33640759, 31198634, 25584415, 18365011, 14551213, 22279540, 16740698, 16801397, 30728072, 20712901, 26045618, 28574510, 31520555, 26575169, 11350938, 28150703, 32123862, 33689932, 23226414, 16425286, 25642823, 23352233, 24728078, 31500219, 33357429, 31956373, 32041943, 21135090, 27660268, 25299776, 17341659, 24086494, 30323145, 18204781, 23186163, 25360179, 27145367, 31337843, 12130710, 32491253, 28030813, 24058772, 24275569, 25280942, 32304779, 21801384, 26664907, 19901082, 30302278, 33066004, 29309895, 9343414, 18037959, 23614738, 18196976, 24469975, 22937084, 15522880, 20154216, 10660304, 24667661, 29604049, 25544757, 23928694, 22418867, 32774719, 29050266, 25116684, 20595392, 11922392, 28350087, 28542650, 29949238, 16651438, 33446662, 21878628, 16288304, 31398350, 21490133, 29571296
S754 Phosphorylation RLIMS-P 28188292
Site PTM Type PTM Enzyme Score Source PMID
Y539 Phosphorylation HPRD 19901323
Y657 Phosphorylation HPRD 15037656
Y674 Phosphorylation HPRD 15037656
K685 Acetylation PR:Q09472 (hEP300) PRO 15653507, 19506034
Y686 Phosphorylation HPRD 17016520, 16497976
S691 Phosphorylation HPRD 17525332
Y705 Phosphorylation P23458 (JAK1) , P12931 (SRC) , O60674 (JAK2) , P22607 (FGFR3) , P08631 (HCK) , P29320 (EPHA3) , P22455 (FGFR4) HPRD 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095, 16497976
T714 Phosphorylation HPRD 18691976, 18669648
T717 Phosphorylation HPRD 18669648
S727 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) , O75582 (RPS6KA5) , P45983 (MAPK8) , Q05655 (PRKCD) HPRD 19413330, 18691976, 12763138, ...10446219, 12576423, 20058876, 11350938, 9872331, 10521505, 18669648, 18491316, 14551213, 20068231, 9343414
Site PTM Type PTM Enzyme Score Source PMID
Y539 Phosphorylation HPRD   PhosphoSitePlus 19901323
K685 Ubiquitination PhosphoSitePlus
S691 Phosphorylation PhosphoSitePlus
Y704 Phosphorylation P12931 (SRC) , O60674 (JAK2) , P08631 (HCK) , P22455 (FGFR4) , P23458 (JAK1) , P22607 (FGFR3) HPRD   PhosphoSitePlus 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095
K706 Ubiquitination PhosphoSitePlus
T707 Phosphorylation PhosphoSitePlus
T713 Phosphorylation HPRD   PhosphoSitePlus 18691976, 18669648
T716 Phosphorylation HPRD 18669648
S726 Phosphorylation O75582 (RPS6KA5) , P45983 (MAPK8) , Q05655 (PRKCD) , P27361 (MAPK3) , P28482 (MAPK1) HPRD 19413330, 18691976, 12763138, ...9343414, 12576423, 20058876, 11350938, 9872331, 10521505, 18669648, 18491316, 14551213, 20068231
Site PTM Type PTM Enzyme Score Source PMID
Y539 Phosphorylation HPRD 19901323
Y686 Phosphorylation HPRD 17016520, 16497976
S691 Phosphorylation HPRD 17525332
Y705 Phosphorylation O60674 (JAK2) , P29320 (EPHA3) HPRD   PhosphoSitePlus 17016520, 10918587, 12576423, ...8626374, 11350938, 14551213, 17389395, 19901323, 12626508, 11294897, 11940572, 12244095, 16497976


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000027924 (hSTAT3/iso:1/Ac:1) acK685 PR:Q09472 (hEP300) PRO 15653507, 19506034


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P00533 (EGFR) Y1092 P40763 (STAT3) unknown eFIP 14966128
Phosphorylation P04626 (ERBB2) Y1139 P40763 (STAT3) unknown eFIP 11940572
Phosphorylation P07949 (RET) Y928 P40763 (STAT3) unknown eFIP 11536047
Phosphorylation P40763 (STAT3) Y705 P42224 (STAT1) unknown eFIP 8662591
Phosphorylation P40763 (STAT3) Y705 P09467 (FBP1) decreased_association eFIP 31938049
Phosphorylation P40763 (STAT3) Y705 P42227 (Stat3) unknown eFIP 8662591
Phosphorylation P40763 (STAT3) Y705 unknown eFIP 8662591
Phosphorylation P40763 (STAT3) Y705 P40763 (STAT3) unknown eFIP 7510216
Phosphorylation P40763 (STAT3) Y705 inhibited_association eFIP 23125416
Phosphorylation P40763 (STAT3) S727 P10275 (AR) unknown eFIP 23941877
Phosphorylation P40763 (STAT3) S727 P10275 (AR) unknown eFIP 30470788
Phosphorylation P40763 (STAT3) S727 P15692 (VEGFA) unknown eFIP 22696236
Phosphorylation P40763 (STAT3) Y705 Q9Y2H2 (INPP5F) unknown eFIP 25476455
Phosphorylation P40763 (STAT3) Y705 P05231 (IL6) unknown eFIP 22280969
Phosphorylation P40763 (STAT3) Y705 P40763 (STAT3) unknown eFIP 26898989
Phosphorylation P40763 (STAT3) Y705 O43474 (KLF4) unknown eFIP 24129709
Phosphorylation Q08345 (DDR1) Y869 P40763 (STAT3) unknown eFIP 22057045
Phosphorylation Q99062 (CSF3R) Y727 P40763 (STAT3) unknown eFIP 9864141


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S25 I25 Biomuta DOID:3070 / malignant glioma [ tcga ]
S25 N25 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
Y45 C45 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K363 I363 Biomuta DOID:1324 / lung cancer [ cosmic ]
K365 Q365 Biomuta DOID:363 / uterine cancer [ tcga ]
T440 I440 Biomuta DOID:169 / neuroendocrine tumor [ tcga ]
K495 N495 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S540 L540 Biomuta DOID:2394 / ovarian cancer [ tcga ]
K615 N615 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K615 R615 Biomuta DOID:2531 / hematologic cancer [ icgc ]
T632 I632 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S636 F636 Biomuta DOID:1612 / breast cancer [ tcga ]
Y640 F640 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:2531 / hematologic cancer [ tcga ] DOID:0070003 / blastoma [ cosmic ]
T641 R641 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
T641 I641 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
K642 E642 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K679 N679 Biomuta DOID:363 / uterine cancer [ tcga ]
Y686 D686 Biomuta DOID:363 / uterine cancer [ tcga ]
S691 C691 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T717 N717 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S719 N719 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S727 P727 Biomuta DOID:2531 / hematologic cancer [ icgc ]