iPTMnet Report for P37268 (FDFT1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P37268 / FDFT_HUMAN
Protein Name Squalene synthase
Gene Name Name: FDFT1
Organism Homo sapiens (Human)

PRO ID PR:P37268
DAG View
PRO Name squalene synthase (human)
Definition A squalene synthase that is encoded in the genome of human.
Short Label hFDFT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P37268 (FDFT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Ubiquitination PhosphoSitePlus
C6 S-Nitrosylation dbSNO 19483679
Y14 Phosphorylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
C43 Methylation IEDB 31844290
K45 Ubiquitination PhosphoSitePlus
C70 Methylation IEDB 31844290
K92 Ubiquitination PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
T127 Phosphorylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
C147 Methylation IEDB 31844290
K160 Ubiquitination PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
C172 Methylation IEDB 31844290
K213 Ubiquitination PhosphoSitePlus
C258 Methylation IEDB 31844290
C289 Methylation IEDB 31844290
C303 Methylation IEDB 31844290
K318 Ubiquitination PhosphoSitePlus
Y346 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y14 C14 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K45 R45 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K93 R93 Biomuta DOID:263 / kidney cancer [ cosmic ]
T127 M127 Biomuta DOID:1612 / breast cancer [ cosmic ]
S129 F129 Biomuta DOID:4159 / skin cancer [ cosmic ]
S129 Y129 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S352 L352 Biomuta DOID:10534 / stomach cancer [ cosmic ]