Protein Information

Cytoscape View


UniProt AC / UniProt ID P37268 / FDFT_HUMAN
Protein Name Squalene synthase
Gene Name Name: FDFT1
Organism Homo sapiens (Human)

PRO ID PR:P37268
DAG View
PRO Name squalene synthase (human)
Definition A squalene synthase that is encoded in the genome of human.
Short Label hFDFT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P37268 (FDFT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Ubiquitination PhosphoSitePlus
C6 S-Nitrosylation dbSNO 19483679
Y14 Phosphorylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
T127 Phosphorylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
Y346 Phosphorylation PhosphoSitePlus
S352 Phosphorylation PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K45 R45 Biomuta DOID:3963 / thyroid carcinoma [ icgc ]
K93 R93 Biomuta DOID:263 / kidney cancer [ cosmic ]
T127 M127 Biomuta DOID:1612 / breast cancer [ tcga ]
S129 F129 Biomuta DOID:1909 / melanoma [ tcga ]
S129 Y129 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
S352 L352 Biomuta DOID:10534 / stomach cancer [ cosmic ]