iPTMnet Report P36956 SREBF1

Protein Information

UniProt AC / UniProt ID	P36956 / SRBP1_HUMAN
Protein Name	Sterol regulatory element-binding protein 1
Gene Name	Name: SREBF1 Synonyms:BHLHD1,SREBP1;
Organism	Homo sapiens (Human)

PRO ID	PR:P36956 DAG View
PRO Name	sterol regulatory element-binding protein 1 (human)
Definition	A sterol regulatory element-binding protein 1 that is encoded in the genome of human.
Short Label	hSREBF1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P36956 (SREBF1) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position T59 S63 S117 K123 K256 T275 S312 K313 R321 K324 K333 S337 S338 K342 K347 K356 K359 S360 K365 K379 K381 S396 K398 S402 K418 T424 T426 S430 S434 S439 S448 S450 S455 S457 S467 K470 S486 Y567 K587 C656 K675 K727 T728 C898 K924 K934 K947 S1020 S1027 S1049 S1060 K1070 K1121	PTM Type Select all Acetylation Methylation Phosphorylation Sumoylation Ubiquitination	PTM Enzyme	Score Select all 0 1 2 3 4	Source Select all IEDB PhosphoSitePlus RLIMS-P RLIMS-P+ Signor UniProt neXtProt phospho.ELM	PMID
T59	Phosphorylation		score1	PhosphoSitePlus
S63	Phosphorylation	Q16539 (MAPK14)	score2	PhosphoSitePlus	22384276
S117	Phosphorylation	P27361 (MAPK3) , P28482 (MAPK1) , P45983 (MAPK8)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	22384276, 10915800, 20863500, ...18669648
K123	Sumoylation		score1	PhosphoSitePlus
K256	Ubiquitination		score1	PhosphoSitePlus
T275	Phosphorylation		score1	PhosphoSitePlus
S312	Phosphorylation		score1	PhosphoSitePlus
K313	Ubiquitination		score1	PhosphoSitePlus
R321	Methylation		score1	PhosphoSitePlus
K324	Acetylation		score1	PhosphoSitePlus
K324	Ubiquitination		score1	PhosphoSitePlus
K333	Acetylation		score1	PhosphoSitePlus
S337	Phosphorylation	P57059 (SIK1)	score2	neXtProt	19244231
S338	Phosphorylation	P57059 (SIK1) , P17612 (PRKACA)	score4	neXtProt PhosphoSitePlus RLIMS-P Signor	19244231, 16381800
K342	Ubiquitination		score1	PhosphoSitePlus
K347	Ubiquitination		score1	PhosphoSitePlus
K356	Ubiquitination		score1	PhosphoSitePlus
K359	Ubiquitination		score1	PhosphoSitePlus
S360	Phosphorylation		score1	PhosphoSitePlus
K365	Ubiquitination		score1	PhosphoSitePlus
K379	Ubiquitination		score1	PhosphoSitePlus
K381	Ubiquitination		score1	PhosphoSitePlus
S396	Phosphorylation	P54646 (PRKAA2)	score3	PhosphoSitePlus Signor	21459323
K398	Ubiquitination		score1	PhosphoSitePlus
S402	Phosphorylation	P57059 (SIK1)	score2	neXtProt	19244231
K418	Sumoylation		score1	PhosphoSitePlus
T424	Phosphorylation		score0	RLIMS-P	27579997
T426	Phosphorylation	P49841 (GSK3B) , Q16539 (MAPK14)	score4	PhosphoSitePlus RLIMS-P Signor	22384276, 19126544, 16825193, ...27579997
S430	Phosphorylation	P49841 (GSK3B)	score4	PhosphoSitePlus RLIMS-P Signor	26759235, 19126544, 16825193, ...27579997
S434	Phosphorylation	P49841 (GSK3B)	score3	PhosphoSitePlus RLIMS-P Signor	19126544
S439	Phosphorylation	P06493 (CDK1)	score3	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor	16880739
S448	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S450	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S455	Phosphorylation		score1	PhosphoSitePlus
S457	Phosphorylation		score1	PhosphoSitePlus
S467	Phosphorylation	P53350 (PLK1)	score2	RLIMS-P+	27579997
K470	Ubiquitination		score1	PhosphoSitePlus
S486	Phosphorylation		score0	RLIMS-P	27579997
Y567	Phosphorylation		score1	PhosphoSitePlus
K587	Ubiquitination		score1	PhosphoSitePlus
C656	Methylation		score1	IEDB	31844290
K675	Ubiquitination		score1	PhosphoSitePlus
K727	Ubiquitination		score1	PhosphoSitePlus
T728	Phosphorylation		score1	IEDB	32387766
C898	Methylation		score1	IEDB	31844290
K924	Methylation		score1	PhosphoSitePlus
K924	Ubiquitination		score1	PhosphoSitePlus
K934	Ubiquitination		score1	PhosphoSitePlus
K947	Ubiquitination		score1	PhosphoSitePlus
S1020	Phosphorylation		score1	PhosphoSitePlus
S1027	Phosphorylation		score1	PhosphoSitePlus
S1049	Phosphorylation		score1	PhosphoSitePlus
S1060	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
K1070	Ubiquitination		score1	PhosphoSitePlus
K1121	Ubiquitination		score1	PhosphoSitePlus

Search:

Site Select all By amino acid All Serine By position S117 K324 K333 S448 S450 S1019 S1020	PTM Type Select all Acetylation Phosphorylation	PTM Enzyme	Score Select all 0 2	Source Select all HPRD PRO	PMID
S117	Phosphorylation	P27361 (MAPK3) , P28482 (MAPK1)	score2	HPRD	10915800, 18669648
K324	Acetylation	PR:000007102 (EP300)	score2	PRO	12640139
K333	Acetylation	PR:000007102 (EP300)	score2	PRO	12640139
S448	Phosphorylation		score0	HPRD	18669648
S450	Phosphorylation		score0	HPRD	18669648
S1019	Phosphorylation		score0	HPRD	17081983
S1020	Phosphorylation		score0	HPRD	17081983

Search:

Site Select all By amino acid All Serine All Threonine By position S39 T81 S93 S314 S372 T402 S410 S415	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 1 2 4	Source Select all PhosphoSitePlus neXtProt	PMID
S39	Phosphorylation	Q16539 (MAPK14)	score2	PhosphoSitePlus	25353341
T81	Phosphorylation	P45983 (MAPK8) , P28482 (MAPK1)	score2	PhosphoSitePlus	25353341
S93	Phosphorylation	P45983 (MAPK8) , P28482 (MAPK1)	score2	PhosphoSitePlus	25353341
S314	Phosphorylation	P17612 (PRKACA)	score2	PhosphoSitePlus	16381800
S372	Phosphorylation	Q13131 (PRKAA1)	score2	PhosphoSitePlus	21459323
T402	Phosphorylation	Q16539 (MAPK14)	score4	neXtProt PhosphoSitePlus	25353341, 22684109
S410	Phosphorylation		score1	PhosphoSitePlus
S415	Phosphorylation		score1	PhosphoSitePlus

Search:

Site Select all By amino acid All Serine By position S147 S478 S480 S1049 S1050	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 0 2	Source Select all HPRD	PMID
S147	Phosphorylation	P27361 (MAPK3) , P28482 (MAPK1)	score2	HPRD	10915800, 18669648
S478	Phosphorylation		score0	HPRD	18669648
S480	Phosphorylation		score0	HPRD	18669648
S1049	Phosphorylation		score0	HPRD	17081983
S1050	Phosphorylation		score0	HPRD	17081983

Proteoforms

Search:

	PRO ID (Short Label) Select all PR:000028630 (hSREBF1/iso:1/Ac:1)	Sites Select all acK324,acK333	PTM Enzyme	Source Select all PRO	PMID
	PR:000028630 (hSREBF1/iso:1/Ac:1)	acK324,acK333	PR:000007102 (EP300)	PRO	12640139

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine By position S117 K123 S147 S312 R321 K365 S396 S448 S478 K587	Variant Select all E123 F117 F147 F396 G312 H321 N365 N587 R448 R478	Source Select all Biomuta	Disease [Sample source] Select all DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ] DOID:263 / kidney cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S117	F117	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
K123	E123	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S147	F147	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S312	G312	Biomuta	DOID:263 / kidney cancer [ cosmic, icgc ]
R321	H321	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc ]
K365	N365	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S396	F396	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S448	R448	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S478	R478	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
K587	N587	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P36956 (SREBF1)

Protein Information

Interactive Sequence View

P36956 (SREBF1) as Substrate

Proteoforms

PTM sites affected in variants