Protein Information

Cytoscape View


UniProt AC / UniProt ID P36956 / SRBP1_HUMAN
Protein Name Sterol regulatory element-binding protein 1
Gene Name Name: SREBF1
Synonyms:BHLHD1,SREBP1;
Organism Homo sapiens (Human)

PRO ID PR:P36956
DAG View
PRO Name sterol regulatory element-binding protein 1 (human)
Definition A sterol regulatory element-binding protein 1 that is encoded in the genome of human.
Short Label hSREBF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P36956 (SREBF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T59 Phosphorylation PhosphoSitePlus   RLIMS-P 29514980
S63 Phosphorylation PhosphoSitePlus 22384276
S63 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 22384276
S117 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22384276, 10915800, 20863500, ...18669648
S117 Phosphorylation P27361 (MAPK3) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10915800, 20863500
S117 Phosphorylation P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10915800, 20863500
S117 Phosphorylation P45983 (MAPK8) PhosphoSitePlus 22384276
K123 Sumoylation PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
T275 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
R321 Methylation PhosphoSitePlus
K324 Acetylation PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
K333 Acetylation PhosphoSitePlus
S337 Phosphorylation neXtProt 19244231
S337 Phosphorylation P57059 (SIK1) neXtProt 19244231
S338 Phosphorylation neXtProt   PhosphoSitePlus   Signor 19244231, 16381800
S338 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor 16381800
S338 Phosphorylation P57059 (SIK1) neXtProt 19244231
K342 Ubiquitination PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
K365 Ubiquitination PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
S396 Phosphorylation PhosphoSitePlus   Signor 21459323
S396 Phosphorylation P54646 (PRKAA2) Signor 21459323
K398 Ubiquitination PhosphoSitePlus
S402 Phosphorylation neXtProt 19244231
S402 Phosphorylation P57059 (SIK1) neXtProt 19244231
K418 Sumoylation PhosphoSitePlus
T424 Phosphorylation RLIMS-P 27579997
T426 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 22384276, 19126544, 16825193, ...27579997
T426 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   Signor 19126544, 16825193
T426 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 22384276
S430 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 26759235, 19126544, 16825193, ...27579997
S430 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   Signor 19126544, 16825193
S434 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 19126544
S434 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   Signor 19126544
S439 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 16880739
S439 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor 16880739
S448 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S450 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S455 Phosphorylation PhosphoSitePlus
S457 Phosphorylation PhosphoSitePlus
S467 Phosphorylation RLIMS-P+ 27579997
S467 Phosphorylation P53350 (PLK1) RLIMS-P+ 27579997
K470 Ubiquitination PhosphoSitePlus
S486 Phosphorylation RLIMS-P 27579997
Y567 Phosphorylation PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
K675 Ubiquitination PhosphoSitePlus
K727 Ubiquitination PhosphoSitePlus
K924 Methylation PhosphoSitePlus
K924 Ubiquitination PhosphoSitePlus
K934 Ubiquitination PhosphoSitePlus
K947 Ubiquitination PhosphoSitePlus
S1020 Phosphorylation PhosphoSitePlus
S1027 Phosphorylation PhosphoSitePlus
S1049 Phosphorylation PhosphoSitePlus
S1060 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1070 Ubiquitination PhosphoSitePlus
K1121 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S117 Phosphorylation HPRD 10915800, 18669648
S117 Phosphorylation P27361 (MAPK3) HPRD 10915800, 18669648
S117 Phosphorylation P28482 (MAPK1) HPRD 10915800, 18669648
K324 Acetylation PRO 12640139
K324 Acetylation PR:000007102 (EP300) PRO 12640139
K333 Acetylation PRO 12640139
K333 Acetylation PR:000007102 (EP300) PRO 12640139
S448 Phosphorylation HPRD 18669648
S450 Phosphorylation HPRD 18669648
S1019 Phosphorylation HPRD 17081983
S1020 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S39 Phosphorylation PhosphoSitePlus 25353341
S39 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 25353341
T81 Phosphorylation PhosphoSitePlus 25353341
T81 Phosphorylation P28482 (MAPK1) PhosphoSitePlus 25353341
T81 Phosphorylation P45983 (MAPK8) PhosphoSitePlus 25353341
S93 Phosphorylation PhosphoSitePlus 25353341
S93 Phosphorylation P28482 (MAPK1) PhosphoSitePlus 25353341
S93 Phosphorylation P45983 (MAPK8) PhosphoSitePlus 25353341
S314 Phosphorylation PhosphoSitePlus 16381800
S314 Phosphorylation P17612 (PRKACA) PhosphoSitePlus 16381800
S372 Phosphorylation PhosphoSitePlus 21459323
S372 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus 21459323
T402 Phosphorylation neXtProt   PhosphoSitePlus 25353341, 22684109
T402 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 25353341
S410 Phosphorylation PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S147 Phosphorylation HPRD 10915800, 18669648
S147 Phosphorylation P27361 (MAPK3) HPRD 10915800, 18669648
S147 Phosphorylation P28482 (MAPK1) HPRD 10915800, 18669648
S478 Phosphorylation HPRD 18669648
S480 Phosphorylation HPRD 18669648
S1049 Phosphorylation HPRD 17081983
S1050 Phosphorylation HPRD 17081983


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000028630 (hSREBF1/iso:1/Ac:1) acK324,acK333 PR:000007102 (EP300) PRO 12640139


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S117 F117 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S312 G312 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
R321 H321 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K379 I379 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S396 F396 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S467 R467 Biomuta DOID:3571 / liver cancer [ icgc ]
S486 F486 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K587 N587 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]