iPTMnet Report for P35968 (KDR)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35968 / VGFR2_HUMAN
Protein Name Vascular endothelial growth factor receptor 2 precursor
Gene Name Name: KDR
Synonyms:FLK1,VEGFR2;
Organism Homo sapiens (Human)

PRO ID PR:P35968
DAG View
PRO Name vascular endothelial growth factor receptor 2 (human)
Definition A vascular endothelial growth factor receptor 2 that is encoded in the genome of human.
Short Label hKDR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35968 (KDR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N96 N-Glycosylation GlyGen 23090970, 24190977
N143 N-Glycosylation GlyGen   UniProt 20145116
S229 Phosphorylation Q00535 (CDK5) PhosphoSitePlus   RLIMS-P+ 27438154
N245 N-Glycosylation GlyGen   UniProt 20145116, 21827946
N318 N-Glycosylation GlyGen   UniProt 20145116, 21827946
T477 O-Glycosylation GlyGen 30459171
S711 Phosphorylation PhosphoSitePlus
Y801 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 18936167, 19526984, 11741094, ...17303569
R819 Methylation PhosphoSitePlus
Y822 Phosphorylation PhosphoSitePlus
S825 Phosphorylation PhosphoSitePlus
Y951 Phosphorylation P35968 (KDR) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10579917, 19015446, 18377662, ...19136612, 23382918, 18936167, 21858086, 35605916, 28869531, 12771128, 16391297, 24648957, 26378810, 24225480, 32184452, 21047416, 26067165, 25158262, 33972548, 7999104, 27882935, 22174934, 20084057, 17658244, 19923922, 11435426, 15962004, 29743977, 24508097, 29964354, 10102632, 21752276, 25874616, 19240722
K960 Acetylation PhosphoSitePlus
S982 Phosphorylation PhosphoSitePlus   UniProt 21406692
S984 Phosphorylation PhosphoSitePlus   UniProt 21406692
Y996 Phosphorylation P35968 (KDR) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 7999104, 18377662, 12771128, ...10579917, 29743977, 35767310, 10102632, 20084057, 18936167, 22356893, 21858086, 19240722
Y1008 Phosphorylation IntAct 12598525
Y1054 Phosphorylation P35968 (KDR) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18083107, 7999104, 17658244, ...15215251, 10506722, 22174934, 21858086, 35767310, 10102632, 15962004, 16835467, 29450744, 17372230, 10579917, 18936167, 10037737, 22393126
K1055 Ubiquitination PhosphoSitePlus
Y1059 Phosphorylation P35968 (KDR) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10579917, 10102632, 23536763, ...25102966, 11435426, 16835467, 18936167, 10368301, 21858086, 28869531, 28101054, 29450744, 7999104, 18377662, 22174934, 22356893, 10037737, 17658244, 15215251, 15962004, 17372230, 18083107, 10506722
Y1175 Phosphorylation P12931 (SRC) , P35968 (KDR) IntAct   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23905676, 30096614, 23536763, ...32274611, 10579917, 28178265, 28695371, 17110601, 24505433, 21653826, 26378810, 25102966, 24225480, 32995772, 32184452, 33076322, 18377662, 19050761, 22174934, 30910851, 27052508, 31060904, 17658244, 12214271, 30800223, 22763125, 23731702, 25910937, 35767310, 18936167, 19372461, 21858086, 26179332, 20657775, 29450744, 27589831, 26804176, 24786599, 20084057, 30282966, 23286511, 25515662, 24312323, 23383198, 32681389, 30518776, 27713170, 28693139, 25967108, 19136612, 28963481, 20843378, 18931684, 28392095, 11387210, 21533119, 22363548, 33787218, 15026417, 25393739, 33846818, 33972548, 14532277, 24358167, 26655500, 26459808, 21505453, 16835467, 23382918, 22304225, 24508097, 29964354, 25415226, 20151671, 28817576, 22016776, 27612418, 27657036, 21539813, 35605916, 29193887, 29628979, 26067165, 25158262, 25354586, 27882935, 25298192, 22382862, 31527750, 18662404, 19367276, 23583373, 31042676, 10749680, 29743977, 21853101, 23139789
Y1214 Phosphorylation P35968 (KDR) IntAct   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16966330, 32274611, 14991896, ...25967108, 28963481, 16835467, 20176926, 21858086, 11387210, 29193887, 20657775, 18936167, 12023952, 24965046, 23059825, 27589831, 26067165, 25158262, 25354586, 27882935, 26655500, 24052076, 22174934, 14724572, 21751212, 19136612, 17658244, 23583373, 15962004, 25415226, 24312323, 28572685
T1217 Phosphorylation PhosphoSitePlus
Y1223 Phosphorylation PhosphoSitePlus
S1231 O-Glycosylation GlyGen 36089631, 35254053
S1235 O-Glycosylation GlyGen 36089631, 35254053
S1235 Phosphorylation PhosphoSitePlus
T1238 Phosphorylation PhosphoSitePlus
K1270 Sumoylation PhosphoSitePlus
S1279 Phosphorylation PhosphoSitePlus
S1281 Phosphorylation PhosphoSitePlus
S1288 Phosphorylation PhosphoSitePlus
S1290 Phosphorylation PhosphoSitePlus
Y1305 Phosphorylation P35968 (KDR) UniProt 15962004
Y1309 Phosphorylation P35968 (KDR) UniProt 15962004
Y1319 Phosphorylation P35968 (KDR) UniProt 15962004
Site PTM Type PTM Enzyme Score Source PMID
Y951 Phosphorylation P35968 (KDR) HPRD 10579917
Y996 Phosphorylation P35968 (KDR) HPRD 10579917
Y1054 Phosphorylation P35968 (KDR) HPRD   PRO 10579917, 25698653
Y1059 Phosphorylation P35968 (KDR) HPRD   PRO 10579917, 25698653, 10368301
Y1175 Phosphorylation HPRD 10749680
Y1214 Phosphorylation HPRD 12023952, 16966330, 11387210
T1238 Phosphorylation HPRD 19664994


P35968 (KDR) as PTM Enzyme



Substrate Site Score Source PMID
P07737 (PFN1) Y129 PhosphoSitePlus 23000962
P35916 (FLT4) Y1230 neXtProt 12881528
P35916 (FLT4) Y1231 neXtProt 12881528
P35916 (FLT4) Y1265 neXtProt 12881528
P35916 (FLT4) Y1333 neXtProt 12881528
P35968 (KDR) Y951 HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 7999104, 10579917, 10102632, ...17658244, 15962004
P35968 (KDR) Y996 HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 7999104, 10579917, 10102632
P35968 (KDR) Y1054 HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 7999104, 10579917, 17372230, ...10102632, 17658244, 10037737
P35968 (KDR) Y1059 HPRD   PhosphoSitePlus   Signor   UniProt 7999104, 10579917, 17372230, ...10102632, 17658244, 10368301, 10037737
P35968 (KDR) Y1175 phospho.ELM   PhosphoSitePlus   Signor   UniProt 17658244, 10579917, 11387210
P35968 (KDR) Y1214 phospho.ELM   PhosphoSitePlus   Signor   UniProt 17658244, 12023952, 11387210
P35968 (KDR) Y1305 UniProt 15962004
P35968 (KDR) Y1309 UniProt 15962004
P35968 (KDR) Y1319 UniProt 15962004


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048097 (hKDR/SigPep-/Phos:2) pY801,pY951,pY1054,pY1059,pY1175,pY1214 PRO
PR:000045766 (hKDR/iso:1/Phos:1) pY1059 PRO 10368301
PR:000049804 (hKDR/iso:1/Phos:2) pY1054,pY1059 PRO 25698653


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P35968 (KDR) Y1175 P41159 (LEP) unknown eFIP 21533119
Phosphorylation Q03135 (CAV1) Y14 P35968 (KDR) unknown eFIP 12529448


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036631 (hNRP1/iso:1/ClvOGlyco:1) Interaction PR:P35968 (hKDR) PRO 16763549
PR:000036632 (hNRP1/iso:1/ClvOGlyco:2) decreased Interaction PR:P35968 (hKDR) PRO 16763549
PR:000036635 (hNRP1/iso:1/SigPep-) Interaction PR:P35968 (hKDR) PRO 16763549


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N96 I96 Biomuta DOID:1324 / lung cancer [ cosmic ]
N143 H143 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
N143 K143 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S229 N229 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
N318 I318 Biomuta DOID:1612 / breast cancer [ cosmic ]
R819 * Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3953 / adrenal gland cancer [ cosmic ]
R819 Q819 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y822 C822 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S825 R825 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S982 Y982 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S984 I984 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S984 T984 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1055 T1055 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1231 N1231 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1231 R1231 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1270 N1270 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1279 F1279 Biomuta [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1279 Y1279 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1281 F1281 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S1290 N1290 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1290 R1290 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S1290 I1290 Biomuta DOID:363 / uterine cancer [ icgc ]
Y1309 D1309 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y1319 C1319 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y1319 * Biomuta DOID:3571 / liver cancer [ cosmic ]