iPTMnet Report P35968 KDR

Protein Information

UniProt AC / UniProt ID	P35968 / VGFR2_HUMAN
Protein Name	Vascular endothelial growth factor receptor 2 precursor
Gene Name	Name: KDR Synonyms:FLK1,VEGFR2;
Organism	Homo sapiens (Human)

PRO ID	PR:P35968 DAG View
PRO Name	vascular endothelial growth factor receptor 2 (human)
Definition	A vascular endothelial growth factor receptor 2 that is encoded in the genome of human.
Short Label	hKDR
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P35968 (KDR) as Substrate

Condensed View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position N96 N143 S229 N245 N318 T477 S711 Y801 R819 Y822 S825 Y951 K960 S982 S984 Y996 Y1008 Y1054 K1055 Y1059 Y1175 Y1214 T1217 Y1223 S1231 S1235 T1238 K1270 S1279 S1281 S1288 S1290 Y1305 Y1309 Y1319	PTM Type Select all Acetylation Methylation N-Glycosylation O-Glycosylation Phosphorylation Sumoylation Ubiquitination	PTM Enzyme Select all P12931 (SRC) P35968 (KDR) Q00535 (CDK5)	Score Select all 1 2 3 4	Source Select all GlyGen IntAct PRO PhosphoSitePlus RLIMS-P RLIMS-P+ Signor UniProt phospho.ELM	PMID
N96	N-Glycosylation		score1	GlyGen	23090970, 24190977
N143	N-Glycosylation		score3	GlyGen UniProt	20145116
S229	Phosphorylation		score3	PhosphoSitePlus RLIMS-P+	27438154
S229	Phosphorylation	Q00535 (CDK5)	score2	RLIMS-P+	27438154
N245	N-Glycosylation		score4	GlyGen UniProt	20145116, 21827946
N318	N-Glycosylation		score4	GlyGen UniProt	20145116, 21827946
T477	O-Glycosylation		score1	GlyGen	30459171
S711	Phosphorylation		score1	PhosphoSitePlus
Y801	Phosphorylation		score4	phospho.ELM PRO PhosphoSitePlus RLIMS-P UniProt	18936167, 19526984, 11741094, ...17303569
R819	Methylation		score1	PhosphoSitePlus
Y822	Phosphorylation		score1	PhosphoSitePlus
S825	Phosphorylation		score1	PhosphoSitePlus
Y951	Phosphorylation		score4	phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	10579917, 19015446, 18377662, ...19136612, 23382918, 18936167, 21858086, 35605916, 28869531, 12771128, 16391297, 24648957, 26378810, 24225480, 32184452, 21047416, 26067165, 25158262, 33972548, 7999104, 27882935, 22174934, 20084057, 17658244, 19923922, 11435426, 15962004, 29743977, 24508097, 29964354, 10102632, 21752276, 25874616, 19240722
Y951	Phosphorylation	P35968 (KDR)	score4	phospho.ELM PhosphoSitePlus Signor UniProt	7999104, 10579917, 10102632, ...17658244, 15962004
K960	Acetylation		score1	PhosphoSitePlus
S982	Phosphorylation		score2	PhosphoSitePlus UniProt	21406692
S984	Phosphorylation		score2	PhosphoSitePlus UniProt	21406692
Y996	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	7999104, 18377662, 12771128, ...10579917, 29743977, 35767310, 10102632, 20084057, 18936167, 22356893, 21858086, 19240722
Y996	Phosphorylation	P35968 (KDR)	score4	phospho.ELM PhosphoSitePlus Signor UniProt	7999104, 10579917, 10102632
Y1008	Phosphorylation		score2	IntAct	12598525
Y1054	Phosphorylation		score4	phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	18083107, 7999104, 17658244, ...15215251, 10506722, 22174934, 21858086, 35767310, 10102632, 15962004, 16835467, 29450744, 17372230, 10579917, 18936167, 10037737, 22393126
Y1054	Phosphorylation	P35968 (KDR)	score4	phospho.ELM PhosphoSitePlus Signor UniProt	7999104, 10579917, 17372230, ...10102632, 17658244, 10037737
K1055	Ubiquitination		score1	PhosphoSitePlus
Y1059	Phosphorylation		score4	phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	10579917, 10102632, 23536763, ...25102966, 11435426, 16835467, 18936167, 10368301, 21858086, 28869531, 28101054, 29450744, 7999104, 18377662, 22174934, 22356893, 10037737, 17658244, 15215251, 15962004, 17372230, 18083107, 10506722
Y1059	Phosphorylation	P35968 (KDR)	score4	PhosphoSitePlus Signor UniProt	7999104, 10037737, 10102632, ...17372230, 17658244
Y1175	Phosphorylation		score4	IntAct phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	23905676, 30096614, 23536763, ...32274611, 10579917, 28178265, 28695371, 17110601, 24505433, 21653826, 26378810, 25102966, 24225480, 32995772, 32184452, 33076322, 18377662, 19050761, 22174934, 30910851, 27052508, 31060904, 17658244, 12214271, 30800223, 22763125, 23731702, 25910937, 35767310, 18936167, 19372461, 21858086, 26179332, 20657775, 29450744, 27589831, 26804176, 24786599, 20084057, 30282966, 23286511, 25515662, 24312323, 23383198, 32681389, 30518776, 27713170, 28693139, 25967108, 19136612, 28963481, 20843378, 18931684, 28392095, 11387210, 21533119, 22363548, 33787218, 15026417, 25393739, 33846818, 33972548, 14532277, 24358167, 26655500, 26459808, 21505453, 16835467, 23382918, 22304225, 24508097, 29964354, 25415226, 20151671, 28817576, 22016776, 27612418, 27657036, 21539813, 35605916, 29193887, 29628979, 26067165, 25158262, 25354586, 27882935, 25298192, 22382862, 31527750, 18662404, 19367276, 23583373, 31042676, 10749680, 29743977, 21853101, 23139789
Y1175	Phosphorylation	P12931 (SRC)	score2	PhosphoSitePlus	19050761
Y1175	Phosphorylation	P35968 (KDR)	score4	phospho.ELM PhosphoSitePlus Signor UniProt	17658244, 10579917, 11387210
Y1214	Phosphorylation		score4	IntAct phospho.ELM PRO PhosphoSitePlus RLIMS-P Signor UniProt	16966330, 32274611, 14991896, ...25967108, 28963481, 16835467, 20176926, 21858086, 11387210, 29193887, 20657775, 18936167, 12023952, 24965046, 23059825, 27589831, 26067165, 25158262, 25354586, 27882935, 26655500, 24052076, 22174934, 14724572, 21751212, 19136612, 17658244, 23583373, 15962004, 25415226, 24312323, 28572685
Y1214	Phosphorylation	P35968 (KDR)	score4	phospho.ELM PhosphoSitePlus Signor UniProt	17658244, 12023952, 11387210
T1217	Phosphorylation		score1	PhosphoSitePlus
Y1223	Phosphorylation		score1	PhosphoSitePlus
S1231	O-Glycosylation		score3	GlyGen	36089631, 35254053
S1235	O-Glycosylation		score3	GlyGen	36089631, 35254053
S1235	Phosphorylation		score1	PhosphoSitePlus
T1238	Phosphorylation		score1	PhosphoSitePlus
K1270	Sumoylation		score1	PhosphoSitePlus
S1279	Phosphorylation		score1	PhosphoSitePlus
S1281	Phosphorylation		score1	PhosphoSitePlus
S1288	Phosphorylation		score1	PhosphoSitePlus
S1290	Phosphorylation		score1	PhosphoSitePlus
Y1305	Phosphorylation		score2	UniProt	15962004
Y1305	Phosphorylation	P35968 (KDR)	score2	UniProt	15962004
Y1309	Phosphorylation		score2	UniProt	15962004
Y1309	Phosphorylation	P35968 (KDR)	score2	UniProt	15962004
Y1319	Phosphorylation		score2	UniProt	15962004
Y1319	Phosphorylation	P35968 (KDR)	score2	UniProt	15962004

Search:

Site Select all By amino acid All Threonine All Tyrosine By position Y951 Y996 Y1054 Y1059 Y1175 Y1214 T1238	PTM Type Select all Phosphorylation	PTM Enzyme Select all P35968 (KDR)	Score Select all 0 1 2 4	Source Select all HPRD PRO	PMID
Y951	Phosphorylation		score1	HPRD	10579917
Y951	Phosphorylation	P35968 (KDR)	score1	HPRD	10579917
Y996	Phosphorylation		score1	HPRD	10579917
Y996	Phosphorylation	P35968 (KDR)	score1	HPRD	10579917
Y1054	Phosphorylation		score4	HPRD PRO	10579917, 25698653
Y1054	Phosphorylation	P35968 (KDR)	score1	HPRD	10579917
Y1059	Phosphorylation		score4	HPRD PRO	10579917, 25698653, 10368301
Y1059	Phosphorylation	P35968 (KDR)	score2	HPRD	10579917, 10368301
Y1175	Phosphorylation		score1	HPRD	10749680
Y1214	Phosphorylation		score2	HPRD	12023952, 16966330, 11387210
T1238	Phosphorylation		score0	HPRD	19664994

P35968 (KDR) as PTM Enzyme

Protein as Phosphorylation Enzyme

Search:

Substrate Select all P07737 (PFN1) P35916 (FLT4) P35968 (KDR)	Site Select all By amino acid All Tyrosine By position Y129 Y951 Y996 Y1054 Y1059 Y1175 Y1214 Y1230 Y1231 Y1265 Y1305 Y1309 Y1319 Y1333	Score Select all 2 4	Source Select all HPRD PhosphoSitePlus Signor UniProt neXtProt phospho.ELM	PMID
P07737 (PFN1)	Y129	score2	PhosphoSitePlus	23000962
P35916 (FLT4)	Y1230	score2	neXtProt	12881528
P35916 (FLT4)	Y1231	score2	neXtProt	12881528
P35916 (FLT4)	Y1265	score2	neXtProt	12881528
P35916 (FLT4)	Y1333	score2	neXtProt	12881528
P35968 (KDR)	Y951	score4	HPRD phospho.ELM PhosphoSitePlus Signor UniProt	7999104, 10579917, 10102632, ...17658244, 15962004
P35968 (KDR)	Y996	score4	HPRD phospho.ELM PhosphoSitePlus Signor UniProt	7999104, 10579917, 10102632
P35968 (KDR)	Y1054	score4	HPRD phospho.ELM PhosphoSitePlus Signor UniProt	7999104, 10579917, 17372230, ...10102632, 17658244, 10037737
P35968 (KDR)	Y1059	score4	HPRD PhosphoSitePlus Signor UniProt	7999104, 10579917, 17372230, ...10102632, 17658244, 10368301, 10037737
P35968 (KDR)	Y1175	score4	phospho.ELM PhosphoSitePlus Signor UniProt	17658244, 10579917, 11387210
P35968 (KDR)	Y1214	score4	phospho.ELM PhosphoSitePlus Signor UniProt	17658244, 12023952, 11387210
P35968 (KDR)	Y1305	score2	UniProt	15962004
P35968 (KDR)	Y1309	score2	UniProt	15962004
P35968 (KDR)	Y1319	score2	UniProt	15962004

Proteoforms

Search:

PRO ID (Short Label) Select all PR:000045766 (hKDR/iso:1/Phos:1) PR:000048097 (hKDR/SigPep-/Phos:2) PR:000049804 (hKDR/iso:1/Phos:2)	Sites Select all pY1054,pY1059 pY1059 pY801,pY951,pY1054,pY1059,pY1175,pY1214	Source Select all PRO	PMID
PR:000048097 (hKDR/SigPep-/Phos:2)	pY801,pY951,pY1054,pY1059,pY1175,pY1214	PRO
PR:000045766 (hKDR/iso:1/Phos:1)	pY1059	PRO	10368301
PR:000049804 (hKDR/iso:1/Phos:2)	pY1054,pY1059	PRO	25698653

PTM-dependent PPI

Search:

	PTM type Select all Phosphorylation	Substrate Select all P35968 (KDR) Q03135 (CAV1)	Site Select all By amino acid All Tyrosine By position Y14 Y1175	Interactant Select all P35968 (KDR) P41159 (LEP)	Association type Select all unknown	Source Select all eFIP	PMID
	Phosphorylation	P35968 (KDR)	Y1175	P41159 (LEP)	unknown	eFIP	21533119
	Phosphorylation	Q03135 (CAV1)	Y14	P35968 (KDR)	unknown	eFIP	12529448

Proteoform PPIs

Search:

Protein 1 Select all PR:000036631 (hNRP1/iso:1/ClvOGlyco:1) PR:000036632 (hNRP1/iso:1/ClvOGlyco:2) PR:000036635 (hNRP1/iso:1/SigPep-)	Relation Select all Interaction decreased Interaction	Protein 2 Select all PR:P35968 (hKDR)	Source Select all PRO	PMID
PR:000036631 (hNRP1/iso:1/ClvOGlyco:1)	Interaction	PR:P35968 (hKDR)	PRO	16763549
PR:000036632 (hNRP1/iso:1/ClvOGlyco:2)	decreased Interaction	PR:P35968 (hKDR)	PRO	16763549
PR:000036635 (hNRP1/iso:1/SigPep-)	Interaction	PR:P35968 (hKDR)	PRO	16763549

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Tyrosine By position N96 N143 S229 N318 R819 Y822 S825 S982 S984 K1055 S1231 K1270 S1279 S1281 S1290 Y1309 Y1319	Variant Select all * C1319 C822 D1309 F1279 F1281 H143 I1290 I318 I96 I984 K143 N1231 N1270 N1290 N229 Q819 R1231 R1290 R825 T1055 T984 Y1279 Y982	Source Select all Biomuta	Disease [Sample source] Select all DOID:1319 / brain cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:3953 / adrenal gland cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
N96	I96	Biomuta	DOID:1324 / lung cancer [ cosmic ]
N143	H143	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
N143	K143	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S229	N229	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
N318	I318	Biomuta	DOID:1612 / breast cancer [ cosmic ]
R819	*	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:3953 / adrenal gland cancer [ cosmic ]
R819	Q819	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
Y822	C822	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S825	R825	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S982	Y982	Biomuta	DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S984	I984	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
S984	T984	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K1055	T1055	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1231	N1231	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S1231	R1231	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K1270	N1270	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1279	F1279	Biomuta	[ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1279	Y1279	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S1281	F1281	Biomuta	DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S1290	N1290	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S1290	R1290	Biomuta	DOID:1319 / brain cancer [ cosmic, icgc ]
S1290	I1290	Biomuta	DOID:363 / uterine cancer [ icgc ]
Y1309	D1309	Biomuta	DOID:4159 / skin cancer [ cosmic ]
Y1319	C1319	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
Y1319	*	Biomuta	DOID:3571 / liver cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P35968 (KDR)

Protein Information

Interactive Sequence View

P35968 (KDR) as Substrate

P35968 (KDR) as PTM Enzyme

Proteoforms

PTM-dependent PPI

Proteoform PPIs

PTM sites affected in variants