iPTMnet Report for P35914 (HMGCL)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35914 / HMGCL_HUMAN
Protein Name Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor
Gene Name Name: HMGCL
Organism Homo sapiens (Human)

PRO ID PR:P35914
DAG View
PRO Name hydroxymethylglutaryl-CoA lyase, mitochondrial (human)
Definition A hydroxymethylglutaryl-CoA lyase, mitochondrial that is encoded in the genome of human.
Short Label hHMGCL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35914 (HMGCL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S17 Phosphorylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
T23 Phosphorylation PhosphoSitePlus
K48 Acetylation PhosphoSitePlus   UniProt 19608861
K48 Ubiquitination PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
K80 Methylation PhosphoSitePlus
K93 Acetylation PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
K137 Acetylation PhosphoSitePlus
Y198 Phosphorylation PhosphoSitePlus
C323 S-Nitrosylation dbSNO 26338901
K324 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K48 Acetylation PRO 19608861


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000025736 (hHMGCL/iso:1/Ac:1) acK48 PRO 19608861


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S17 F17 Biomuta DOID:4159 / skin cancer [ cosmic ]
S78 F78 Biomuta DOID:184 / bone cancer [ cosmic ]
S78 Y78 Biomuta DOID:1319 / brain cancer [ icgc ]
K137 R137 Biomuta DOID:10534 / stomach cancer [ cosmic ]