iPTMnet Report for P35914 (HMGCL)
Protein Information
UniProt AC / UniProt ID | P35914 / HMGCL_HUMAN |
Protein Name | Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor |
Gene Name | Name: HMGCL |
Organism | Homo sapiens (Human) |
PRO ID | PR:P35914 |
PRO Name | hydroxymethylglutaryl-CoA lyase, mitochondrial (human) |
Definition | A hydroxymethylglutaryl-CoA lyase, mitochondrial that is encoded in the genome of human. |
Short Label | hHMGCL |
Category | organism-gene |
P35914 (HMGCL) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S17 | Phosphorylation | score1 | PhosphoSitePlus | |||
S22 | Phosphorylation | score1 | PhosphoSitePlus | |||
T23 | Phosphorylation | score1 | PhosphoSitePlus | |||
K48 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K48 | Ubiquitination | score1 | PhosphoSitePlus | |||
S78 | Phosphorylation | score1 | PhosphoSitePlus | |||
K80 | Methylation | score1 | PhosphoSitePlus | |||
K93 | Acetylation | score1 | PhosphoSitePlus | |||
K93 | Ubiquitination | score1 | PhosphoSitePlus | |||
K137 | Acetylation | score1 | PhosphoSitePlus | |||
Y198 | Phosphorylation | score1 | PhosphoSitePlus | |||
C323 | S-Nitrosylation | score0 | dbSNO | 26338901 | ||
K324 | Acetylation | score1 | PhosphoSitePlus |
Proteoforms
PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
---|---|---|---|---|---|
PR:000025736 (hHMGCL/iso:1/Ac:1) | acK48 | PRO | 19608861 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S17 | F17 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
S78 | F78 | Biomuta | DOID:184 / bone cancer [ cosmic ] | |
S78 | Y78 | Biomuta | DOID:1319 / brain cancer [ icgc ] | |
K137 | R137 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] |