Protein Information

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UniProt AC / UniProt ID P35611 / ADDA_HUMAN
Protein Name Alpha-adducin
Gene Name Name: ADD1
Synonyms:ADDA;
Organism Homo sapiens (Human)

PRO ID PR:P35611
DAG View
PRO Name alpha-adducin (human)
Definition An alpha-adducin that is encoded in the genome of human.
Short Label hADD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35611 (ADD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
S5 Phosphorylation phospho.ELM 15611095, 16116087, 8810272, ...9679146
T11 Phosphorylation PhosphoSitePlus
S12 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 29925526, 21406692, 18088087, ...24379415, 18669648, 23186163
S12 Phosphorylation P06493 (CDK1) PhosphoSitePlus 24379415
T16 Phosphorylation PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
Y24 Phosphorylation PhosphoSitePlus
R27 Methylation PhosphoSitePlus
Y35 Phosphorylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
S59 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 24275569, 8810272
S64 Phosphorylation PhosphoSitePlus   UniProt 24275569
K140 Acetylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
T331 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S334 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K348 Ubiquitination PhosphoSitePlus
S353 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 23186163
S355 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 29925526, 24379415, 23186163, ...17287340, 15822905
S355 Phosphorylation P06493 (CDK1) PhosphoSitePlus 24379415
S358 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 18088087, 15302935, ...18669648, 17287340, 24275569, 23186163, 15822905
T364 Phosphorylation PhosphoSitePlus
S366 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Y393 Phosphorylation PhosphoSitePlus
Y395 Phosphorylation PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
S408 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 8810272
S408 Phosphorylation P17612 (PRKACA) neXtProt 8810272
S423 Phosphorylation PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus
T429 Phosphorylation PhosphoSitePlus
S431 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S436 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 17081983, 8810272
S436 Phosphorylation P17612 (PRKACA) neXtProt 8810272
K439 Ubiquitination PhosphoSitePlus
T445 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10209029, 10947843, 15910744
T445 Phosphorylation O75116 (ROCK2) neXtProt 10209029
T445 Phosphorylation Q13464 (ROCK1) phospho.ELM   PhosphoSitePlus   Signor 10209029
T445 Phosphorylation Q9Y5S2 (CDC42BPB) neXtProt 10947843
S457 Phosphorylation PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus
S465 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 28982183, 21406692, 23186163, ...17081983, 15302935, 18669648, 17287340, 19690332, 20068231
T480 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 10209029
T480 Phosphorylation O75116 (ROCK2) neXtProt 10209029
T480 Phosphorylation Q13464 (ROCK1) PhosphoSitePlus   Signor 10209029
S481 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 8810272
S481 Phosphorylation P17612 (PRKACA) neXtProt 8810272
T482 Phosphorylation PhosphoSitePlus
S483 Phosphorylation PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
C525 S-Nitrosylation dbSNO 26338901
R531 Methylation PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
T540 O-Glycosylation GlyGen 23301498, 32119511, 28657654, ...29351928
S542 O-Glycosylation GlyGen 23301498, 32119511, 28657654, ...29351928
Y550 Phosphorylation PhosphoSitePlus
S557 O-Glycosylation GlyGen 23301498, 32119511, 28657654, ...29351928
T558 O-Glycosylation GlyGen 23301498, 32119511, 28657654, ...29351928
T559 O-Glycosylation GlyGen 23301498, 32119511, 28657654, ...29351928
T559 Phosphorylation PhosphoSitePlus
T565 O-Glycosylation GlyGen 23301498, 32119511, 28657654, ...29351928
T568 O-Glycosylation GlyGen 23301498, 32119511, 28657654, ...29351928
Y575 Phosphorylation PhosphoSitePlus
S586 Phosphorylation PhosphoSitePlus
S600 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S613 Phosphorylation PhosphoSitePlus 18847512
S613 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T614 Phosphorylation PhosphoSitePlus 18847512
T614 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
S645 Phosphorylation PhosphoSitePlus
S669 Phosphorylation PhosphoSitePlus
T671 Phosphorylation PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus   UniProt 24275569
S707 Phosphorylation PhosphoSitePlus   UniProt 21406692, 17081983, 24275569
S710 Phosphorylation PhosphoSitePlus   UniProt 21406692, 17081983
S714 Phosphorylation PhosphoSitePlus   UniProt 21406692
S716 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 24711455, 24275569, ...8810272, 9679146
S716 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 24711455, 9679146
T724 Phosphorylation PhosphoSitePlus   RLIMS-P 31548578
S726 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 29925526, 17081983, 16116087, ...15611095, 31548578, 17341583, 21851590, 8810272, 15910744, 12743105, 9679146
S726 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
S726 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   Signor 16116087, 8810272, 12743105, ...9679146
S726 Phosphorylation P17612 (PRKACA) neXtProt 8810272
S726 Phosphorylation Q05513 (PRKCZ) PhosphoSitePlus   Signor 15611095, 8810272, 9679146
S726 Phosphorylation Q05655 (PRKCD) PhosphoSitePlus 17341583
S731 Phosphorylation PhosphoSitePlus
S735 Phosphorylation PhosphoSitePlus
S737 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T11 Phosphorylation HPRD 20068231
S12 Phosphorylation HPRD 18088087, 18767875, 19664995, ...18669648, 19415658, 20068231
T331 Phosphorylation HPRD 18669648
S334 Phosphorylation HPRD 18669648
S353 Phosphorylation HPRD 17287340, 19664995, 20068231
S355 Phosphorylation HPRD 19413330, 17287340, 20058876, ...19664995, 18510355, 20166139, 20068231
S358 Phosphorylation HPRD 19413330, 18510355, 18491316, ...17287340, 18767875, 15302935, 19664995, 18452278, 19651622, 19664994, 18669648, 20058876, 20166139, 18088087, 19415658, 20068231
T364 Phosphorylation HPRD 20068231
S366 Phosphorylation HPRD 18669648, 19664994
S408 Phosphorylation HPRD 8810272
S408 Phosphorylation P17612 (PRKACA) HPRD 8810272
S420 Phosphorylation HPRD 17081983
S423 Phosphorylation HPRD 17081983
T429 Phosphorylation HPRD 17081983
S431 Phosphorylation HPRD 18669648, 19664995
S436 Phosphorylation HPRD 18669648, 8810272
S436 Phosphorylation P17612 (PRKACA) HPRD 18669648, 8810272
T445 Phosphorylation HPRD 10209029
T445 Phosphorylation Q13464 (ROCK1) HPRD 10209029
S464 Phosphorylation HPRD 19413330, 19651622, 17081983, ...20068231, 19664995
S465 Phosphorylation HPRD 19413330, 17287340, 15302935, ...19664995, 19651622, 18669648, 20166139, 20068231
T480 Phosphorylation HPRD 10209029
T480 Phosphorylation Q13464 (ROCK1) HPRD 10209029
T482 Phosphorylation HPRD 20068231
S586 Phosphorylation HPRD 19651622
S600 Phosphorylation HPRD 18510355
S613 Phosphorylation HPRD 17081983
T614 Phosphorylation HPRD 17081983
S669 Phosphorylation HPRD 17081983
T675 Phosphorylation HPRD 17081983
S695 Phosphorylation HPRD 8810272, 9679146
S695 Phosphorylation Q05655 (PRKCD) HPRD 8810272, 9679146
S707 Phosphorylation HPRD 20058876, 17081983
S710 Phosphorylation HPRD 17081983
S716 Phosphorylation HPRD 17081983
S726 Phosphorylation HPRD 19413330
Site PTM Type PTM Enzyme Score Source PMID
T11 Phosphorylation HPRD 20068231
S12 Phosphorylation HPRD 18088087, 18767875, 19664995, ...18669648, 19415658, 20068231
T331 Phosphorylation HPRD 18669648
S334 Phosphorylation HPRD 18669648
S353 Phosphorylation HPRD 17287340, 19664995, 20068231
S355 Phosphorylation HPRD 19413330, 17287340, 20058876, ...19664995, 18510355, 20166139, 20068231
S358 Phosphorylation HPRD 19413330, 17322306, 18491316, ...18088087, 18767875, 19664994, 19664995, 18452278, 19651622, 18510355, 18669648, 20058876, 20166139, 17287340, 19415658, 20068231
T364 Phosphorylation HPRD 20068231
S366 Phosphorylation HPRD 18669648, 19664994
S408 Phosphorylation HPRD 8810272
S408 Phosphorylation P17612 (PRKACA) HPRD 8810272
S420 Phosphorylation HPRD 17081983
S423 Phosphorylation HPRD 17081983
T429 Phosphorylation HPRD 17081983
S431 Phosphorylation HPRD 18669648, 19664995
S436 Phosphorylation HPRD 18669648, 8810272
S436 Phosphorylation P17612 (PRKACA) HPRD 18669648, 8810272
T445 Phosphorylation HPRD 10209029
T445 Phosphorylation Q13464 (ROCK1) HPRD 10209029
S464 Phosphorylation HPRD 19413330, 19651622, 17081983, ...20068231, 19664995
S465 Phosphorylation HPRD 19413330, 17287340, 15302935, ...19664995, 19651622, 18669648, 20166139, 20068231
T480 Phosphorylation HPRD 10209029
T480 Phosphorylation Q13464 (ROCK1) HPRD 10209029
T482 Phosphorylation HPRD 20068231
Y550 Phosphorylation PhosphoSitePlus
S586 Phosphorylation HPRD 19651622
S600 Phosphorylation HPRD 18510355
S613 Phosphorylation HPRD 17081983
T614 Phosphorylation HPRD 17081983
Y628 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T11 Phosphorylation HPRD 20068231
S12 Phosphorylation HPRD 18088087, 18767875, 19664995, ...18669648, 19415658, 20068231
T331 Phosphorylation HPRD 18669648
S334 Phosphorylation HPRD 18669648
S353 Phosphorylation HPRD 17287340, 19664995, 20068231
S355 Phosphorylation HPRD 19413330, 17287340, 20058876, ...19664995, 18510355, 20166139, 20068231
S358 Phosphorylation HPRD 19413330, 18510355, 18491316, ...17287340, 18767875, 15302935, 19664995, 18452278, 19651622, 19664994, 18669648, 20058876, 20166139, 18088087, 19415658, 20068231
T364 Phosphorylation HPRD 20068231
S366 Phosphorylation HPRD 18669648, 19664994
S408 Phosphorylation HPRD 8810272
S408 Phosphorylation P17612 (PRKACA) HPRD 8810272
S420 Phosphorylation HPRD 17081983
S423 Phosphorylation HPRD 17081983
T429 Phosphorylation HPRD 17081983
S431 Phosphorylation HPRD 18669648, 19664995
S436 Phosphorylation HPRD 18669648, 8810272
S436 Phosphorylation P17612 (PRKACA) HPRD 18669648, 8810272
T445 Phosphorylation HPRD 10209029
T445 Phosphorylation Q13464 (ROCK1) HPRD 10209029
S464 Phosphorylation HPRD 19413330, 19651622, 17081983, ...20068231, 19664995
S465 Phosphorylation HPRD 19413330, 17287340, 15302935, ...19664995, 19651622, 18669648, 20166139, 20068231
T511 Phosphorylation HPRD 10209029
T511 Phosphorylation Q13464 (ROCK1) HPRD 10209029
T513 Phosphorylation HPRD 20068231
S617 Phosphorylation HPRD 19651622
S631 Phosphorylation HPRD 18510355
S644 Phosphorylation HPRD 17081983
T645 Phosphorylation HPRD 17081983
S700 Phosphorylation HPRD 17081983
T706 Phosphorylation HPRD 17081983
S726 Phosphorylation HPRD 8810272, 9679146
S726 Phosphorylation Q05655 (PRKCD) HPRD 8810272, 9679146
S738 Phosphorylation HPRD 20058876, 17081983
S741 Phosphorylation HPRD 17081983
S747 Phosphorylation HPRD 17081983
S757 Phosphorylation HPRD 19413330
Site PTM Type PTM Enzyme Score Source PMID
S557 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T11 Phosphorylation HPRD 20068231
S12 Phosphorylation HPRD 18088087, 18767875, 19664995, ...18669648, 19415658, 20068231
T331 Phosphorylation HPRD 18669648
S334 Phosphorylation HPRD 18669648
S353 Phosphorylation HPRD 17287340, 19664995, 20068231
S355 Phosphorylation HPRD 19413330, 17287340, 20058876, ...19664995, 18510355, 20166139, 20068231
S358 Phosphorylation HPRD 19413330, 17322306, 18491316, ...18088087, 18767875, 19664994, 19664995, 18452278, 19651622, 18510355, 18669648, 20058876, 20166139, 17287340, 19415658, 20068231
T364 Phosphorylation HPRD 20068231
S366 Phosphorylation HPRD 18669648, 19664994
S408 Phosphorylation HPRD 8810272
S408 Phosphorylation P17612 (PRKACA) HPRD 8810272
S420 Phosphorylation HPRD 17081983
S423 Phosphorylation HPRD 17081983
T429 Phosphorylation HPRD 17081983
S431 Phosphorylation HPRD 18669648, 19664995
S436 Phosphorylation HPRD 18669648, 8810272
S436 Phosphorylation P17612 (PRKACA) HPRD 18669648, 8810272
T445 Phosphorylation HPRD 10209029
T445 Phosphorylation Q13464 (ROCK1) HPRD 10209029
S464 Phosphorylation HPRD 19413330, 19651622, 17081983, ...20068231, 19664995
S465 Phosphorylation HPRD 19413330, 17287340, 15302935, ...19664995, 19651622, 18669648, 20166139, 20068231
T511 Phosphorylation HPRD 10209029
T511 Phosphorylation Q13464 (ROCK1) HPRD 10209029
T513 Phosphorylation HPRD 20068231
S617 Phosphorylation HPRD 19651622
S631 Phosphorylation HPRD 18510355
S644 Phosphorylation HPRD 17081983
T645 Phosphorylation HPRD 17081983


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P35611 (ADD1) S726 Q9ULW0 (TPX2) unknown eFIP 29925526