iPTMnet Report for P35611 (ADD1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35611 / ADDA_HUMAN
Protein Name Alpha-adducin
Gene Name Name: ADD1
Synonyms:ADDA;
Organism Homo sapiens (Human)

PRO ID PR:P35611
DAG View
PRO Name alpha-adducin (human)
Definition An alpha-adducin that is encoded in the genome of human.
Short Label hADD1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35611 (ADD1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
S5 Phosphorylation phospho.ELM 15611095, 16116087, 8810272, ...9679146
T11 Phosphorylation PhosphoSitePlus
S12 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 29925526, 21406692, 23186163, ...24379415, 18669648, 18088087
T16 Phosphorylation PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
Y24 Phosphorylation PhosphoSitePlus
R27 Methylation PhosphoSitePlus
Y35 Phosphorylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
S59 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 24275569, 8810272
S64 Phosphorylation PhosphoSitePlus   UniProt 24275569
K140 Acetylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
T331 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S334 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K348 Ubiquitination PhosphoSitePlus
S353 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 23186163
S355 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 29925526, 24379415, 23186163, ...17287340, 15822905
S358 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 15302935, ...18669648, 24275569, 23186163, 18088087, 15822905
T364 Phosphorylation PhosphoSitePlus
S366 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Y393 Phosphorylation PhosphoSitePlus
Y395 Phosphorylation PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
S408 Phosphorylation P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 8810272
S423 Phosphorylation PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus
T429 Phosphorylation PhosphoSitePlus
S431 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S436 Phosphorylation P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 17081983, 8810272
K439 Ubiquitination PhosphoSitePlus
T445 Phosphorylation Q9Y5S2 (CDC42BPB) , Q13464 (ROCK1) , O75116 (ROCK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10209029, 10947843, 15910744
S457 Phosphorylation PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus
S465 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 17081983, ...15302935, 18669648, 23186163, 19690332, 20068231
T480 Phosphorylation Q13464 (ROCK1) , O75116 (ROCK2) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 10209029
S481 Phosphorylation P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 8810272
T482 Phosphorylation PhosphoSitePlus
S483 Phosphorylation PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
S521 O-Glycosylation GlyGen 23301498, 35008409, 34725712, ...31492838, 29351928, 35132862, 32119511, 35254053, 28657654
C525 S-Nitrosylation dbSNO 26338901
R531 Methylation PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
T540 O-Glycosylation GlyGen 23301498, 35008409, 34725712, ...31492838, 29351928, 35132862, 32119511, 35254053, 28657654
S542 O-Glycosylation GlyGen 23301498, 35008409, 34725712, ...31492838, 29351928, 35132862, 32119511, 35254053, 28657654
Y550 Phosphorylation PhosphoSitePlus
S557 O-Glycosylation GlyGen 23301498, 35008409, 34725712, ...31492838, 29351928, 35132862, 32119511, 35254053, 28657654
T558 O-Glycosylation GlyGen 23301498, 35008409, 34725712, ...31492838, 29351928, 35132862, 32119511, 35254053, 28657654
T559 O-Glycosylation GlyGen 23301498, 35008409, 34725712, ...31492838, 29351928, 35132862, 32119511, 35254053, 28657654
T559 Phosphorylation PhosphoSitePlus
T565 O-Glycosylation GlyGen 23301498, 35008409, 34725712, ...31492838, 29351928, 35132862, 32119511, 35254053, 28657654
T568 O-Glycosylation GlyGen 23301498, 35008409, 34725712, ...31492838, 29351928, 35132862, 32119511, 35254053, 28657654
Y575 Phosphorylation PhosphoSitePlus
S586 Phosphorylation PhosphoSitePlus
S600 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S613 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T614 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
S645 Phosphorylation PhosphoSitePlus
S669 Phosphorylation PhosphoSitePlus
T671 Phosphorylation PhosphoSitePlus
S678 Phosphorylation PhosphoSitePlus   UniProt 24275569
S707 Phosphorylation PhosphoSitePlus   UniProt 21406692, 17081983, 24275569
S710 Phosphorylation PhosphoSitePlus   UniProt 21406692, 17081983
S714 Phosphorylation PhosphoSitePlus   UniProt 21406692
S716 Phosphorylation P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   UniProt 17081983, 24711455, 24275569, ...8810272, 9679146
T724 Phosphorylation PhosphoSitePlus   RLIMS-P 31548578
S726 Phosphorylation O14757 (CHEK1) , P17612 (PRKACA) , Q05513 (PRKCZ) , P17252 (PRKCA) , Q05655 (PRKCD) IEDB   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 29925526, 32897882, 17081983, ...16116087, 15611095, 15910744, 17341583, 21851590, 8810272, 31548578, 12743105, 9679146
S731 Phosphorylation IEDB   PhosphoSitePlus 32897882
S735 Phosphorylation PhosphoSitePlus
S737 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T11 Phosphorylation HPRD 20068231
S12 Phosphorylation HPRD 18088087, 18767875, 19664995, ...18669648, 19415658, 20068231
T331 Phosphorylation HPRD 18669648
S334 Phosphorylation HPRD 18669648
S353 Phosphorylation HPRD 17287340, 19664995, 20068231
S355 Phosphorylation HPRD 19413330, 17287340, 20058876, ...19664995, 18510355, 20166139, 20068231
S358 Phosphorylation HPRD 19413330, 18510355, 18491316, ...17287340, 18767875, 15302935, 19664995, 18452278, 19651622, 19664994, 18669648, 20058876, 20166139, 18088087, 19415658, 20068231
T364 Phosphorylation HPRD 20068231
S366 Phosphorylation HPRD 18669648, 19664994
S408 Phosphorylation P17612 (PRKACA) HPRD 8810272
S420 Phosphorylation HPRD 17081983
S423 Phosphorylation HPRD 17081983
T429 Phosphorylation HPRD 17081983
S431 Phosphorylation HPRD 18669648, 19664995
S436 Phosphorylation P17612 (PRKACA) HPRD 18669648, 8810272
T445 Phosphorylation Q13464 (ROCK1) HPRD 10209029
S464 Phosphorylation HPRD 19413330, 19651622, 17081983, ...20068231, 19664995
S465 Phosphorylation HPRD 19413330, 17287340, 15302935, ...19664995, 19651622, 18669648, 20166139, 20068231
T480 Phosphorylation Q13464 (ROCK1) HPRD 10209029
T482 Phosphorylation HPRD 20068231
S586 Phosphorylation HPRD 19651622
S600 Phosphorylation HPRD 18510355
S613 Phosphorylation HPRD 17081983
T614 Phosphorylation HPRD 17081983
S669 Phosphorylation HPRD 17081983
T675 Phosphorylation HPRD 17081983
S695 Phosphorylation Q05655 (PRKCD) HPRD 8810272, 9679146
S707 Phosphorylation HPRD 20058876, 17081983
S710 Phosphorylation HPRD 17081983
S716 Phosphorylation HPRD 17081983
S726 Phosphorylation HPRD 19413330
Site PTM Type PTM Enzyme Score Source PMID
T11 Phosphorylation HPRD 20068231
S12 Phosphorylation HPRD 18088087, 18767875, 19664995, ...18669648, 19415658, 20068231
T331 Phosphorylation HPRD 18669648
S334 Phosphorylation HPRD 18669648
S353 Phosphorylation HPRD 17287340, 19664995, 20068231
S355 Phosphorylation HPRD 19413330, 17287340, 20058876, ...19664995, 18510355, 20166139, 20068231
S358 Phosphorylation HPRD 19413330, 17322306, 18491316, ...18088087, 18767875, 19664994, 19664995, 18452278, 19651622, 18510355, 18669648, 20058876, 20166139, 17287340, 19415658, 20068231
T364 Phosphorylation HPRD 20068231
S366 Phosphorylation HPRD 18669648, 19664994
S408 Phosphorylation P17612 (PRKACA) HPRD 8810272
S420 Phosphorylation HPRD 17081983
S423 Phosphorylation HPRD 17081983
T429 Phosphorylation HPRD 17081983
S431 Phosphorylation HPRD 18669648, 19664995
S436 Phosphorylation P17612 (PRKACA) HPRD 18669648, 8810272
T445 Phosphorylation Q13464 (ROCK1) HPRD 10209029
S464 Phosphorylation HPRD 19413330, 19651622, 17081983, ...20068231, 19664995
S465 Phosphorylation HPRD 19413330, 17287340, 15302935, ...19664995, 19651622, 18669648, 20166139, 20068231
T480 Phosphorylation Q13464 (ROCK1) HPRD 10209029
T482 Phosphorylation HPRD 20068231
Y550 Phosphorylation PhosphoSitePlus
S586 Phosphorylation HPRD 19651622
S600 Phosphorylation HPRD 18510355
S613 Phosphorylation HPRD 17081983
T614 Phosphorylation HPRD 17081983
Y628 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T11 Phosphorylation HPRD 20068231
S12 Phosphorylation HPRD 18088087, 18767875, 19664995, ...18669648, 19415658, 20068231
T331 Phosphorylation HPRD 18669648
S334 Phosphorylation HPRD 18669648
S353 Phosphorylation HPRD 17287340, 19664995, 20068231
S355 Phosphorylation HPRD 19413330, 17287340, 20058876, ...19664995, 18510355, 20166139, 20068231
S358 Phosphorylation HPRD 19413330, 18510355, 18491316, ...17287340, 18767875, 15302935, 19664995, 18452278, 19651622, 19664994, 18669648, 20058876, 20166139, 18088087, 19415658, 20068231
T364 Phosphorylation HPRD 20068231
S366 Phosphorylation HPRD 18669648, 19664994
S408 Phosphorylation P17612 (PRKACA) HPRD 8810272
S420 Phosphorylation HPRD 17081983
S423 Phosphorylation HPRD 17081983
T429 Phosphorylation HPRD 17081983
S431 Phosphorylation HPRD 18669648, 19664995
S436 Phosphorylation P17612 (PRKACA) HPRD 18669648, 8810272
T445 Phosphorylation Q13464 (ROCK1) HPRD 10209029
S464 Phosphorylation HPRD 19413330, 19651622, 17081983, ...20068231, 19664995
S465 Phosphorylation HPRD 19413330, 17287340, 15302935, ...19664995, 19651622, 18669648, 20166139, 20068231
T511 Phosphorylation Q13464 (ROCK1) HPRD 10209029
T513 Phosphorylation HPRD 20068231
S617 Phosphorylation HPRD 19651622
S631 Phosphorylation HPRD 18510355
S644 Phosphorylation HPRD 17081983
T645 Phosphorylation HPRD 17081983
S700 Phosphorylation HPRD 17081983
T706 Phosphorylation HPRD 17081983
S726 Phosphorylation Q05655 (PRKCD) HPRD 8810272, 9679146
S738 Phosphorylation HPRD 20058876, 17081983
S741 Phosphorylation HPRD 17081983
S747 Phosphorylation HPRD 17081983
S757 Phosphorylation HPRD 19413330
Site PTM Type PTM Enzyme Score Source PMID
S557 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T11 Phosphorylation HPRD 20068231
S12 Phosphorylation HPRD 18088087, 18767875, 19664995, ...18669648, 19415658, 20068231
T331 Phosphorylation HPRD 18669648
S334 Phosphorylation HPRD 18669648
S353 Phosphorylation HPRD 17287340, 19664995, 20068231
S355 Phosphorylation HPRD 19413330, 17287340, 20058876, ...19664995, 18510355, 20166139, 20068231
S358 Phosphorylation HPRD 19413330, 17322306, 18491316, ...18088087, 18767875, 19664994, 19664995, 18452278, 19651622, 18510355, 18669648, 20058876, 20166139, 17287340, 19415658, 20068231
T364 Phosphorylation HPRD 20068231
S366 Phosphorylation HPRD 18669648, 19664994
S408 Phosphorylation P17612 (PRKACA) HPRD 8810272
S420 Phosphorylation HPRD 17081983
S423 Phosphorylation HPRD 17081983
T429 Phosphorylation HPRD 17081983
S431 Phosphorylation HPRD 18669648, 19664995
S436 Phosphorylation P17612 (PRKACA) HPRD 18669648, 8810272
T445 Phosphorylation Q13464 (ROCK1) HPRD 10209029
S464 Phosphorylation HPRD 19413330, 19651622, 17081983, ...20068231, 19664995
S465 Phosphorylation HPRD 19413330, 17287340, 15302935, ...19664995, 19651622, 18669648, 20166139, 20068231
T511 Phosphorylation Q13464 (ROCK1) HPRD 10209029
T513 Phosphorylation HPRD 20068231
S617 Phosphorylation HPRD 19651622
S631 Phosphorylation HPRD 18510355
S644 Phosphorylation HPRD 17081983
T645 Phosphorylation HPRD 17081983


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P35611 (ADD1) S726 Q9ULW0 (TPX2) unknown eFIP 29925526


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S408 I408 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S427 P427 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T429 A429 Biomuta DOID:263 / kidney cancer [ cosmic ]
S521 F521 Biomuta DOID:4159 / skin cancer [ cosmic ]
C525 R525 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T540 M540 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
S542 F542 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S557 N557 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T559 M559 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T559 A559 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y575 C575 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S586 C586 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S617 C617 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S695 L695 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S710 F710 Biomuta [ cosmic ]
S714 F714 Biomuta [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1115 / sarcoma [ icgc ] DOID:263 / kidney cancer [ cosmic ]
S726 L726 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S741 F741 Biomuta [ cosmic, cosmic, cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1115 / sarcoma [ icgc ] DOID:263 / kidney cancer [ cosmic ]