iPTMnet Report for P35590 (TIE1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35590 / TIE1_HUMAN
Protein Name Tyrosine-protein kinase receptor Tie-1 precursor
Gene Name Name: TIE1
Synonyms:TIE;
Organism Homo sapiens (Human)

PRO ID PR:P35590
DAG View
PRO Name tyrosine-protein kinase receptor Tie-1 (human)
Definition A tyrosine-protein kinase receptor Tie-1 that is encoded in the genome of human.
Short Label hTIE1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35590 (TIE1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T393 Phosphorylation PhosphoSitePlus
S397 O-Glycosylation GlyGen 30620550
S472 Phosphorylation PhosphoSitePlus
S478 Phosphorylation PhosphoSitePlus
T539 Phosphorylation PhosphoSitePlus
T540 Phosphorylation PhosphoSitePlus
N596 N-Glycosylation GlyGen 23090970, 24190977
S598 Phosphorylation PhosphoSitePlus
S599 Phosphorylation PhosphoSitePlus
T604 Phosphorylation PhosphoSitePlus
T608 Phosphorylation PhosphoSitePlus
T663 Phosphorylation PhosphoSitePlus
Y912 Phosphorylation PhosphoSitePlus
Y1007 Phosphorylation PhosphoSitePlus
T1011 Phosphorylation PhosphoSitePlus
Y1027 Phosphorylation PhosphoSitePlus
Y1030 Phosphorylation PhosphoSitePlus
T1031 Phosphorylation PhosphoSitePlus
T1032 Phosphorylation PhosphoSitePlus
Y1083 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S516 Phosphorylation HPRD 20068231
Y912 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S397 P397 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S472 F472 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S478 F478 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S598 L598 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T608 M608 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
T663 K663 Biomuta DOID:4159 / skin cancer [ icgc ]
T1011 M1011 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
Y1083 S1083 Biomuta DOID:9256 / colorectal cancer [ icgc ]