iPTMnet Report for P35590 (TIE1)
Protein Information
UniProt AC / UniProt ID | P35590 / TIE1_HUMAN |
Protein Name | Tyrosine-protein kinase receptor Tie-1 precursor |
Gene Name | Name: TIE1 Synonyms:TIE; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P35590 |
PRO Name | tyrosine-protein kinase receptor Tie-1 (human) |
Definition | A tyrosine-protein kinase receptor Tie-1 that is encoded in the genome of human. |
Short Label | hTIE1 |
Category | organism-gene |
P35590 (TIE1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
T393 | Phosphorylation | score1 | PhosphoSitePlus | |||
S397 | O-Glycosylation | score1 | GlyGen | 30620550 | ||
S472 | Phosphorylation | score1 | PhosphoSitePlus | |||
S478 | Phosphorylation | score1 | PhosphoSitePlus | |||
T539 | Phosphorylation | score1 | PhosphoSitePlus | |||
T540 | Phosphorylation | score1 | PhosphoSitePlus | |||
N596 | N-Glycosylation | score1 | GlyGen | 23090970, 24190977 | ||
S598 | Phosphorylation | score1 | PhosphoSitePlus | |||
S599 | Phosphorylation | score1 | PhosphoSitePlus | |||
T604 | Phosphorylation | score1 | PhosphoSitePlus | |||
T608 | Phosphorylation | score1 | PhosphoSitePlus | |||
T663 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y912 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y1007 | Phosphorylation | score1 | PhosphoSitePlus | |||
T1011 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y1027 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y1030 | Phosphorylation | score1 | PhosphoSitePlus | |||
T1031 | Phosphorylation | score1 | PhosphoSitePlus | |||
T1032 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y1083 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S397 | P397 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
S472 | F472 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S478 | F478 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
S598 | L598 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
T608 | M608 | Biomuta | DOID:2394 / ovarian cancer [ cosmic, icgc ] | |
T663 | K663 | Biomuta | DOID:4159 / skin cancer [ icgc ] | |
T1011 | M1011 | Biomuta | DOID:9253 / gastrointestinal stromal tumor [ cosmic ] | |
Y1083 | S1083 | Biomuta | DOID:9256 / colorectal cancer [ icgc ] |