iPTMnet Report for P35558 (PCK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P35558 / PCKGC_HUMAN
Protein Name Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Gene Name Name: PCK1
Synonyms:PEPCK1;
Organism Homo sapiens (Human)

PRO ID PR:P35558
DAG View
PRO Name phosphoenolpyruvate carboxykinase, cytosolic [GTP] (human)
Definition A phosphoenolpyruvate carboxykinase, cytosolic [GTP] that is encoded in the genome of human.
Short Label hPCK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35558 (PCK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation PhosphoSitePlus   UniProt 24275569
K70 Acetylation PhosphoSitePlus   UniProt 21726808, 20167786
K71 Acetylation PhosphoSitePlus   UniProt 21726808, 20167786
S90 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 32809272, 32322062
K91 Acetylation PhosphoSitePlus   UniProt 30193097
T92 Phosphorylation PhosphoSitePlus
T102 O-Glycosylation GlyGen 31492838, 29237092
T178 Phosphorylation PhosphoSitePlus
K204 Acetylation PhosphoSitePlus
S233 Phosphorylation PhosphoSitePlus
Y235 Phosphorylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K244 Acetylation PhosphoSitePlus
K290 Acetylation PhosphoSitePlus
K342 Acetylation PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
K349 Acetylation PhosphoSitePlus
K353 Acetylation PhosphoSitePlus
S379 Phosphorylation IEDB 35494241
K473 Acetylation PhosphoSitePlus
Y557 Phosphorylation PhosphoSitePlus
K594 Acetylation PhosphoSitePlus   UniProt 21726808, 20167786
Site PTM Type PTM Enzyme Score Source PMID
Y557 Phosphorylation HPRD 20068231
Y595 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S90 T90 Biomuta DOID:1324 / lung cancer [ cosmic ]
S90 N90 Biomuta DOID:1319 / brain cancer [ icgc ]
K91 N91 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T102 I102 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K204 R204 Biomuta DOID:4159 / skin cancer [ cosmic ]
K349 R349 Biomuta DOID:363 / uterine cancer [ icgc ]
K473 N473 Biomuta DOID:363 / uterine cancer [ icgc ]
Y557 H557 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]