iPTMnet Report for P35558 (PCK1)
Protein Information
UniProt AC / UniProt ID | P35558 / PCKGC_HUMAN |
Protein Name | Phosphoenolpyruvate carboxykinase, cytosolic [GTP] |
Gene Name | Name: PCK1 Synonyms:PEPCK1; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P35558 |
PRO Name | phosphoenolpyruvate carboxykinase, cytosolic [GTP] (human) |
Definition | A phosphoenolpyruvate carboxykinase, cytosolic [GTP] that is encoded in the genome of human. |
Short Label | hPCK1 |
Category | organism-gene |
P35558 (PCK1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S19 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
K70 | Acetylation | score4 | PhosphoSitePlus UniProt | 21726808, 20167786 | ||
K71 | Acetylation | score4 | PhosphoSitePlus UniProt | 21726808, 20167786 | ||
S90 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 32809272, 32322062 | ||
K91 | Acetylation | score3 | PhosphoSitePlus UniProt | 30193097 | ||
T92 | Phosphorylation | score1 | PhosphoSitePlus | |||
T102 | O-Glycosylation | score1 | GlyGen | 31492838, 29237092 | ||
T178 | Phosphorylation | score1 | PhosphoSitePlus | |||
K204 | Acetylation | score1 | PhosphoSitePlus | |||
S233 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y235 | Phosphorylation | score1 | PhosphoSitePlus | |||
K243 | Ubiquitination | score1 | PhosphoSitePlus | |||
K244 | Acetylation | score1 | PhosphoSitePlus | |||
K290 | Acetylation | score1 | PhosphoSitePlus | |||
K342 | Acetylation | score1 | PhosphoSitePlus | |||
K342 | Ubiquitination | score1 | PhosphoSitePlus | |||
K349 | Acetylation | score1 | PhosphoSitePlus | |||
K353 | Acetylation | score1 | PhosphoSitePlus | |||
S379 | Phosphorylation | score1 | IEDB | 35494241 | ||
K473 | Acetylation | score1 | PhosphoSitePlus | |||
Y557 | Phosphorylation | score1 | PhosphoSitePlus | |||
K594 | Acetylation | score4 | PhosphoSitePlus UniProt | 21726808, 20167786 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S90 | T90 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S90 | N90 | Biomuta | DOID:1319 / brain cancer [ icgc ] | |
K91 | N91 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
T102 | I102 | Biomuta | DOID:263 / kidney cancer [ cosmic, icgc ] | |
K204 | R204 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
K349 | R349 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
K473 | N473 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
Y557 | H557 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] |