Protein Information

Cytoscape View


UniProt AC / UniProt ID P35408 / PE2R4_HUMAN
Protein Name Prostaglandin E2 receptor EP4 subtype
Gene Name Name: PTGER4
Synonyms:PTGER2;
Organism Homo sapiens (Human)

PRO ID PR:P35408
DAG View
PRO Name prostaglandin E2 receptor EP4 subtype (human)
Definition A prostaglandin E2 receptor EP4 subtype that is encoded in the genome of human.
Short Label hPTGER4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P35408 (PTGER4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S222 Phosphorylation phospho.ELM 11597569
S235 Phosphorylation PhosphoSitePlus
S245 Phosphorylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
S259 Phosphorylation phospho.ELM 11597569
K308 Ubiquitination PhosphoSitePlus
T335 Phosphorylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
S354 Phosphorylation phospho.ELM 11597569
S374 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 14709160
S377 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 14709160
S379 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 14709160
S382 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 14709160
S389 Phosphorylation PhosphoSitePlus   RLIMS-P 14709160
S390 Phosphorylation RLIMS-P 14709160
T391 Phosphorylation RLIMS-P 14709160
S392 Phosphorylation RLIMS-P 14709160
T394 Phosphorylation PhosphoSitePlus
S400 Phosphorylation PhosphoSitePlus
S430 Phosphorylation phospho.ELM   PhosphoSitePlus 11597569
T433 Phosphorylation phospho.ELM 11597569
S460 Phosphorylation phospho.ELM 11597569
K468 Ubiquitination PhosphoSitePlus
S484 Phosphorylation phospho.ELM 11597569


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S222 P222 Biomuta DOID:263 / kidney cancer [ tcga ]
S235 P235 Biomuta DOID:3070 / malignant glioma [ icgc ]
S354 P354 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S354 A354 Biomuta DOID:11054 / urinary bladder cancer [ icgc ]
S389 I389 Biomuta DOID:3571 / liver cancer [ icgc ]
S392 Y392 Biomuta DOID:363 / uterine cancer [ tcga ]
S400 L400 Biomuta DOID:1324 / lung cancer [ cosmic ]
S430 P430 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S430 * Biomuta DOID:363 / uterine cancer [ cosmic ]
T433 N433 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S484 L484 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S484 A484 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]