iPTMnet Report for P35408 (PTGER4)
Protein Information
| UniProt AC / UniProt ID | P35408 / PE2R4_HUMAN |
| Protein Name | Prostaglandin E2 receptor EP4 subtype |
| Gene Name | Name: PTGER4 Synonyms:PTGER2; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P35408 |
| PRO Name | prostaglandin E2 receptor EP4 subtype (human) |
| Definition | A prostaglandin E2 receptor EP4 subtype that is encoded in the genome of human. |
| Short Label | hPTGER4 |
| Category | organism-gene |
P35408 (PTGER4) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S222 | Phosphorylation | score2 | phospho.ELM | 11597569 | ||
| S235 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S245 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S252 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S259 | Phosphorylation | score2 | phospho.ELM | 11597569 | ||
| K308 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T335 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S338 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S354 | Phosphorylation | score2 | phospho.ELM | 11597569 | ||
| S374 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus UniProt | 14709160 | ||
| S377 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus UniProt | 14709160 | ||
| S379 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus UniProt | 14709160 | ||
| S382 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus UniProt | 14709160 | ||
| S389 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 14709160 | ||
| S390 | Phosphorylation | score0 | RLIMS-P | 14709160 | ||
| T391 | Phosphorylation | score0 | RLIMS-P | 14709160 | ||
| S392 | Phosphorylation | score0 | RLIMS-P | 14709160 | ||
| T394 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S400 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S430 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus | 11597569 | ||
| T433 | Phosphorylation | score2 | phospho.ELM | 11597569 | ||
| S460 | Phosphorylation | score2 | phospho.ELM | 11597569 | ||
| K468 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S484 | Phosphorylation | score2 | phospho.ELM | 11597569 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S222 | P222 | Biomuta | DOID:263 / kidney cancer [ cosmic, icgc ] | |
| S222 | A222 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| S235 | P235 | Biomuta | DOID:1319 / brain cancer [ icgc ] | |
| S354 | P354 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| S354 | A354 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| S392 | Y392 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| T394 | I394 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S400 | L400 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S430 | P430 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S430 | * | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
| T433 | N433 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S460 | R460 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
| S484 | L484 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| S484 | A484 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] |
DAG View