Protein Information

Cytoscape View


UniProt AC / UniProt ID P34932 / HSP74_HUMAN
Protein Name Heat shock 70 kDa protein 4
Gene Name Name: HSPA4
Synonyms:APG2;
Organism Homo sapiens (Human)

PRO ID PR:P34932
DAG View
PRO Name heat shock 70 kDa protein 4 (human)
Definition A heat shock 70 kDa protein 4 that is encoded in the genome of human.
Short Label hHSPA4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P34932 (HSPA4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus
Y30 Phosphorylation PhosphoSitePlus
S31 Phosphorylation PhosphoSitePlus
R33 Methylation PhosphoSitePlus
C34 S-Nitrosylation dbSNO 19483679, 26338901
C38 S-Nitrosylation dbSNO 19483679, 26338901
K44 Ubiquitination PhosphoSitePlus
K53 Acetylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
S76 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...19690332
K84 Ubiquitination PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
Y89 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455
T96 Phosphorylation PhosphoSitePlus
T99 Phosphorylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
T113 Phosphorylation PhosphoSitePlus
T114 Phosphorylation PhosphoSitePlus
T118 Phosphorylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
Y184 Phosphorylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
K194 Acetylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
T230 Phosphorylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
C245 S-Nitrosylation dbSNO 20140087
K250 Ubiquitination PhosphoSitePlus
R265 Methylation PhosphoSitePlus
K272 Acetylation PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
K329 Acetylation PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
Y336 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15592455, 19690332
K351 Ubiquitination PhosphoSitePlus
K356 Acetylation PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus
K388 Methylation PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus   UniProt 23186163
S408 Phosphorylation PhosphoSitePlus   RLIMS-P 25900241
S415 Phosphorylation PhosphoSitePlus
C417 S-Nitrosylation dbSNO 19483679, 26338901
K422 Acetylation PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
S429 Phosphorylation PhosphoSitePlus
K430 Acetylation PhosphoSitePlus   UniProt 19608861
K430 Ubiquitination PhosphoSitePlus
T433 Phosphorylation PhosphoSitePlus
Y435 Phosphorylation PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
K517 Ubiquitination PhosphoSitePlus
T538 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K543 Ubiquitination PhosphoSitePlus
S546 Phosphorylation PhosphoSitePlus   UniProt 21406692
S552 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S556 Phosphorylation PhosphoSitePlus
K557 Methylation PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
K559 Methylation PhosphoSitePlus
K568 Ubiquitination PhosphoSitePlus
K573 Ubiquitination PhosphoSitePlus
T576 Phosphorylation phospho.ELM 18669648
K603 Acetylation PhosphoSitePlus
K609 Ubiquitination PhosphoSitePlus
K618 Ubiquitination PhosphoSitePlus
Y624 Phosphorylation PhosphoSitePlus
Y626 Phosphorylation PhosphoSitePlus
K631 Acetylation PhosphoSitePlus
K631 Ubiquitination PhosphoSitePlus
S633 Phosphorylation PhosphoSitePlus
Y636 Phosphorylation PhosphoSitePlus
K638 Ubiquitination PhosphoSitePlus
S641 Phosphorylation PhosphoSitePlus
R645 Methylation PhosphoSitePlus
S647 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y660 Phosphorylation PhosphoSitePlus
K668 Ubiquitination PhosphoSitePlus
Y671 Phosphorylation PhosphoSitePlus
K674 Acetylation PhosphoSitePlus
K674 Ubiquitination PhosphoSitePlus
K679 Acetylation PhosphoSitePlus   UniProt 19608861
K679 Ubiquitination PhosphoSitePlus
K686 Ubiquitination PhosphoSitePlus
S692 Phosphorylation PhosphoSitePlus
K697 Ubiquitination PhosphoSitePlus
K704 Ubiquitination PhosphoSitePlus
K711 Ubiquitination PhosphoSitePlus
K717 Ubiquitination PhosphoSitePlus
K719 Ubiquitination PhosphoSitePlus
Y723 Phosphorylation PhosphoSitePlus
K733 Ubiquitination PhosphoSitePlus
K736 Ubiquitination PhosphoSitePlus
K748 Ubiquitination PhosphoSitePlus
K754 Ubiquitination PhosphoSitePlus
S756 Phosphorylation PhosphoSitePlus   UniProt 23186163
K773 Methylation PhosphoSitePlus   UniProt 24129315
K773 Ubiquitination PhosphoSitePlus
S780 Phosphorylation PhosphoSitePlus
S784 Phosphorylation PhosphoSitePlus
K785 Ubiquitination PhosphoSitePlus
K789 Ubiquitination PhosphoSitePlus
K794 Ubiquitination PhosphoSitePlus
K798 Ubiquitination PhosphoSitePlus
S828 Phosphorylation PhosphoSitePlus
S830 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S54 Phosphorylation HPRD 18767875
S58 Phosphorylation HPRD 18767875
S76 Phosphorylation HPRD 19664994, 18669648, 20058876
T113 Phosphorylation HPRD 19664995
T114 Phosphorylation HPRD 19664995
T118 Phosphorylation HPRD 19664995
Y336 Phosphorylation HPRD 15592455
S384 Phosphorylation HPRD 20068231
T395 Phosphorylation HPRD 20068231
S415 Phosphorylation HPRD 19413330
S429 Phosphorylation HPRD 20068231
S474 Phosphorylation HPRD 20068231
T538 Phosphorylation HPRD 18669648, 20068231
S546 Phosphorylation HPRD 19664994
S552 Phosphorylation HPRD 17525332
T576 Phosphorylation HPRD 18669648
T776 Phosphorylation HPRD 20068231
S777 Phosphorylation HPRD 20068231
S780 Phosphorylation HPRD 20068231
S784 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S54 R54 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K61 N61 Biomuta DOID:363 / uterine cancer [ tcga ]
S85 C85 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
Y89 H89 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
Y184 C184 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
R265 Q265 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ] DOID:1612 / breast cancer [ icgc, tcga ]
S278 C278 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S287 I287 Biomuta DOID:3571 / liver cancer [ icgc ]
K305 T305 Biomuta DOID:363 / uterine cancer [ icgc, tcga ] DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
K329 N329 Biomuta DOID:3571 / liver cancer [ icgc ]
K356 T356 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ tcga ]
C417 S417 Biomuta DOID:5041 / esophageal cancer [ icgc ]
C417 * Biomuta DOID:5041 / esophageal cancer [ icgc ]
K430 N430 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
K477 N477 Biomuta DOID:263 / kidney cancer [ cosmic ]
T538 A538 Biomuta DOID:263 / kidney cancer [ cosmic ]
K573 N573 Biomuta DOID:263 / kidney cancer [ cosmic ]
K603 N603 Biomuta DOID:3571 / liver cancer [ icgc ]
Y626 F626 Biomuta DOID:1909 / melanoma [ cosmic ]
R645 G645 Biomuta DOID:1324 / lung cancer [ cosmic ]
K719 N719 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
K733 N733 Biomuta DOID:363 / uterine cancer [ tcga ]
K748 N748 Biomuta DOID:3070 / malignant glioma [ tcga ]
K748 R748 Biomuta DOID:4362 / cervical cancer [ tcga ]
K754 E754 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S784 * Biomuta DOID:11934 / head and neck cancer [ tcga ]
K789 N789 Biomuta DOID:363 / uterine cancer [ tcga ]
S828 L828 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ] DOID:11934 / head and neck cancer [ tcga ]