iPTMnet Report for P34897 (SHMT2)
Protein Information
UniProt AC / UniProt ID | P34897 / GLYM_HUMAN |
Protein Name | Serine hydroxymethyltransferase, mitochondrial precursor |
Gene Name | Name: SHMT2 |
Organism | Homo sapiens (Human) |
PRO ID | PR:P34897 |
PRO Name | serine hydroxymethyltransferase, mitochondrial (human) |
Definition | A serine hydroxymethyltransferase, mitochondrial that is encoded in the genome of human. |
Short Label | hSHMT2 |
Category | organism-gene |
P34897 (SHMT2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y3 | Phosphorylation | score1 | PhosphoSitePlus | |||
S90 | Phosphorylation | score1 | PhosphoSitePlus | |||
K95 | Acetylation | score1 | PhosphoSitePlus | |||
K95 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y96 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y100 | Phosphorylation | score1 | PhosphoSitePlus | |||
K103 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K103 | Ubiquitination | score1 | PhosphoSitePlus | |||
S178 | Phosphorylation | score1 | PhosphoSitePlus | |||
K181 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K181 | Ubiquitination | score1 | PhosphoSitePlus | |||
S184 | Phosphorylation | score1 | PhosphoSitePlus | |||
S192 | Phosphorylation | score1 | PhosphoSitePlus | |||
K196 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K200 | Acetylation | score1 | PhosphoSitePlus | |||
K200 | Ubiquitination | score1 | PhosphoSitePlus | |||
T212 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y228 | Phosphorylation | score1 | PhosphoSitePlus | |||
R230 | Methylation | score1 | PhosphoSitePlus | |||
R236 | Methylation | score1 | PhosphoSitePlus | |||
K245 | Acetylation | score1 | PhosphoSitePlus | |||
K262 | Ubiquitination | score1 | PhosphoSitePlus | |||
S266 | Phosphorylation | score1 | PhosphoSitePlus | |||
K269 | Acetylation | score1 | PhosphoSitePlus | |||
K269 | Methylation | score1 | PhosphoSitePlus | |||
K269 | Ubiquitination | score1 | PhosphoSitePlus | |||
K280 | Ubiquitination | score1 | PhosphoSitePlus | |||
K297 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K297 | Ubiquitination | score1 | PhosphoSitePlus | |||
K302 | Acetylation | score1 | PhosphoSitePlus | |||
Y350 | Phosphorylation | score1 | PhosphoSitePlus | |||
K356 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K356 | Ubiquitination | score1 | PhosphoSitePlus | |||
R368 | Methylation | score1 | PhosphoSitePlus | |||
K389 | Ubiquitination | score1 | PhosphoSitePlus | |||
S404 | Phosphorylation | score1 | PhosphoSitePlus | |||
K409 | Acetylation | score1 | PhosphoSitePlus | |||
K409 | Ubiquitination | score1 | PhosphoSitePlus | |||
R416 | Methylation | score1 | PhosphoSitePlus | |||
T420 | Phosphorylation | score1 | PhosphoSitePlus | |||
R442 | Methylation | score1 | PhosphoSitePlus | |||
K459 | Ubiquitination | score1 | PhosphoSitePlus | |||
K464 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K464 | Ubiquitination | score1 | PhosphoSitePlus | |||
K469 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K469 | Methylation | score1 | PhosphoSitePlus | |||
K469 | Ubiquitination | score1 | PhosphoSitePlus | |||
S470 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K474 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
K474 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
Y3 | H3 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
S90 | Y90 | Biomuta | DOID:1540 / parathyroid carcinoma [ cosmic ] | |
K200 | N200 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
R236 | H236 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] | |
R368 | Q368 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
S404 | F404 | Biomuta | DOID:1319 / brain cancer [ cosmic, icgc ] | |
S404 | C404 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |