iPTMnet Report for P34897 (SHMT2)
Protein Information
| UniProt AC / UniProt ID | P34897 / GLYM_HUMAN |
| Protein Name | Serine hydroxymethyltransferase, mitochondrial precursor |
| Gene Name | Name: SHMT2 |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P34897 |
| PRO Name | serine hydroxymethyltransferase, mitochondrial (human) |
| Definition | A serine hydroxymethyltransferase, mitochondrial that is encoded in the genome of human. |
| Short Label | hSHMT2 |
| Category | organism-gene |
P34897 (SHMT2) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| Y3 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S90 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K95 | Acetylation | score1 | PhosphoSitePlus | |||
| K95 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y96 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y100 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K103 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K103 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S178 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K181 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K181 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S184 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S192 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K196 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K200 | Acetylation | score1 | PhosphoSitePlus | |||
| K200 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T212 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y228 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R230 | Methylation | score1 | PhosphoSitePlus | |||
| R236 | Methylation | score1 | PhosphoSitePlus | |||
| K245 | Acetylation | score1 | PhosphoSitePlus | |||
| K262 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S266 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K269 | Acetylation | score1 | PhosphoSitePlus | |||
| K269 | Methylation | score1 | PhosphoSitePlus | |||
| K269 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K280 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K297 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K297 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K302 | Acetylation | score1 | PhosphoSitePlus | |||
| Y350 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K356 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K356 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R368 | Methylation | score1 | PhosphoSitePlus | |||
| K389 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S404 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K409 | Acetylation | score1 | PhosphoSitePlus | |||
| K409 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R416 | Methylation | score1 | PhosphoSitePlus | |||
| T420 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R442 | Methylation | score1 | PhosphoSitePlus | |||
| K459 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K464 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K464 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K469 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K469 | Methylation | score1 | PhosphoSitePlus | |||
| K469 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S470 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| K474 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K474 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| Y3 | H3 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| S90 | Y90 | Biomuta | DOID:1540 / parathyroid carcinoma [ cosmic ] | |
| K200 | N200 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| R236 | H236 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] | |
| R368 | Q368 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| S404 | F404 | Biomuta | DOID:1319 / brain cancer [ cosmic, icgc ] | |
| S404 | C404 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
DAG View