iPTMnet Report for P33778 (H2BC3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P33778 / H2B1B_HUMAN
Protein Name Histone H2B type 1-B
Gene Name Name: H2BC3
Synonyms:H2BFF,HIST1H2BB;
Organism Homo sapiens (Human)

PRO ID PR:P33778
DAG View
PRO Name histone H2B type 1-B (human)
Definition A histone H2B type 1-B that is encoded in the genome of human.
Short Label hH2BC3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P33778 (H2BC3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Acetylation PRO
K6 Acetylation PRO   UniProt 18552846, 16283522
K12 Acetylation PhosphoSitePlus
K13 Acetylation PRO   UniProt 18552846, 19608861, 20693536, ...16283522
S15 Phosphorylation P26927 (MST1) , Q13043 (STK4) phospho.ELM   PRO   Signor   UniProt 21212262, 12757711
K16 Acetylation PRO   PhosphoSitePlus   UniProt 19608861, 19883641, 16283522
K17 Acetylation PRO   UniProt 19608861, 20693536
K21 Acetylation PRO   UniProt 18552846, 19608861, 16283522
K24 Acetylation PhosphoSitePlus   UniProt 19608861
K28 Acetylation PhosphoSitePlus
S33 Phosphorylation P51812 (RPS6KA3) Signor 21646345
K35 Ubiquitination UniProt 21726816
S37 Phosphorylation P31749 (AKT1) neXtProt 8985174
K47 Acetylation PRO 20693536
S56 Phosphorylation PhosphoSitePlus
S79 O-Glycosylation GlyGen 29351928
T120 O-Glycosylation GlyGen 29351928
K121 Acetylation PRO 18552846
K121 Ubiquitination PRO   UniProt 18400894, 16307923, 19575011, ...16713563, 18923072, 18832071


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000045024 (hHIST1H2BB/InitMet-/Ac:1) acK13 PRO 16283522, 18552846, 20693536
PR:000045025 (hHIST1H2BB/InitMet-/Phos:1) pS15 PRO 12757711
PR:000045026 (hHIST1H2BB/InitMet-/Ac:2) acK21 PRO 16283522, 18552846
PR:000045028 (hHIST1H2BB/InitMet-/Ubiq:1) ubK121 PRO 16307923, 16713563, 18400894, ...18832071, 18923072, 19575011
PR:000045029 (hHIST1H2BB/InitMet-/Ac:3) acK17 PRO 20693536
PR:000045030 (hHIST1H2BB/InitMet-/Ac:4) acK6 PRO 18552846
PR:000045032 (hHIST1H2BB/InitMet-/Ac:5) acK47 PRO 20693536
PR:000045033 (hHIST1H2BB/InitMet-/Ac:6) acK121 PRO 18552846
PR:000045034 (hHIST1H2BB/InitMet-/Ac:7) acK16 PRO 19883641
PR:000047766 (hHIST1H2BB/InitMet-/N6AcLys+) ac PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K6 E6 Biomuta DOID:363 / uterine cancer [ cosmic ]
S15 Y15 Biomuta DOID:363 / uterine cancer [ cosmic ]
K21 E21 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K21 M21 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K24 N24 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K28 N28 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S37 I37 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K121 N121 Biomuta DOID:1612 / breast cancer [ cosmic ]