iPTMnet Report for P33778 (H2BC3)
Protein Information
| UniProt AC / UniProt ID | P33778 / H2B1B_HUMAN |
| Protein Name | Histone H2B type 1-B |
| Gene Name | Name: H2BC3 Synonyms:H2BFF,HIST1H2BB; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P33778 |
| PRO Name | histone H2B type 1-B (human) |
| Definition | A histone H2B type 1-B that is encoded in the genome of human. |
| Short Label | hH2BC3 |
| Category | organism-gene |
DAG ViewP33778 (H2BC3) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Acetylation | score1 | PRO | ||||
| K6 | Acetylation | score2 | PRO UniProt | 18552846, 16283522 | ||
| K12 | Acetylation | score1 | PhosphoSitePlus | |||
| K13 | Acetylation | score2 | PRO UniProt | 18552846, 19608861, 20693536, ... | ||
| S15 | Phosphorylation | score4 | phospho.ELM PRO Signor UniProt | 21212262, 12757711 | ||
| S15 | Phosphorylation | P26927 (MST1) | score4 | phospho.ELM Signor | 21212262, 12757711 | |
| S15 | Phosphorylation | Q13043 (STK4) | score1 | Signor | 21212262 | |
| K16 | Acetylation | score2 | PRO PhosphoSitePlus UniProt | 19608861, 19883641, 16283522 | ||
| K17 | Acetylation | score2 | PRO UniProt | 19608861, 20693536 | ||
| K21 | Acetylation | score2 | PRO UniProt | 18552846, 19608861, 16283522 | ||
| K24 | Acetylation | score2 | PhosphoSitePlus UniProt | 19608861 | ||
| K28 | Acetylation | score1 | PhosphoSitePlus | |||
| S33 | Phosphorylation | score1 | Signor | 21646345 | ||
| S33 | Phosphorylation | P51812 (RPS6KA3) | score1 | Signor | 21646345 | |
| K35 | Ubiquitination | score1 | UniProt | 21726816 | ||
| S37 | Phosphorylation | score2 | neXtProt | 8985174 | ||
| S37 | Phosphorylation | P31749 (AKT1) | score2 | neXtProt | 8985174 | |
| K47 | Acetylation | score1 | PRO | 20693536 | ||
| S56 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S79 | O-Glycosylation | score1 | GlyGen | 29351928 | ||
| T120 | O-Glycosylation | score1 | GlyGen | 29351928 | ||
| K121 | Acetylation | score1 | PRO | 18552846 | ||
| K121 | Ubiquitination | score2 | PRO UniProt | 18400894, 16307923, 19575011, ... |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000045024 (hHIST1H2BB/InitMet-/Ac:1) | acK13 | PRO | 16283522, 18552846, 20693536 | ||
| PR:000045025 (hHIST1H2BB/InitMet-/Phos:1) | pS15 | PRO | 12757711 | ||
| PR:000045026 (hHIST1H2BB/InitMet-/Ac:2) | acK21 | PRO | 16283522, 18552846 | ||
| PR:000045028 (hHIST1H2BB/InitMet-/Ubiq:1) | ubK121 | PRO | 16307923, 16713563, 18400894, ... | ||
| PR:000045029 (hHIST1H2BB/InitMet-/Ac:3) | acK17 | PRO | 20693536 | ||
| PR:000045030 (hHIST1H2BB/InitMet-/Ac:4) | acK6 | PRO | 18552846 | ||
| PR:000045032 (hHIST1H2BB/InitMet-/Ac:5) | acK47 | PRO | 20693536 | ||
| PR:000045033 (hHIST1H2BB/InitMet-/Ac:6) | acK121 | PRO | 18552846 | ||
| PR:000045034 (hHIST1H2BB/InitMet-/Ac:7) | acK16 | PRO | 19883641 | ||
| PR:000047766 (hHIST1H2BB/InitMet-/N6AcLys+) | ac | PRO |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K6 | E6 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
| S15 | Y15 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
| K21 | E21 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
| K21 | M21 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] | |
| K24 | N24 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
| K28 | N28 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
| S37 | I37 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| K121 | N121 | Biomuta | DOID:1612 / breast cancer [ cosmic ] |
