iPTMnet Report for P32298 (GRK4)
Protein Information
| UniProt AC / UniProt ID | P32298 / GRK4_HUMAN |
| Protein Name | G protein-coupled receptor kinase 4 |
| Gene Name | Name: GRK4 Synonyms:GPRK2L,GPRK4; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P32298 |
| PRO Name | G protein-coupled receptor kinase 4 (human) |
| Definition | A G protein-coupled receptor kinase 4 that is encoded in the genome of human. |
| Short Label | hGRK4 |
| Category | organism-gene |
DAG ViewP32298 (GRK4) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| M1 | Acetylation | score1 | UniProt | 22223895 | ||
| S10 | Phosphorylation | score2 | PhosphoSitePlus | 26134571 | ||
| S10 | Phosphorylation | P32298 (GRK4) | score2 | PhosphoSitePlus | 26134571 | |
| K14 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S24 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S139 | Phosphorylation | score2 | PhosphoSitePlus | 26134571 | ||
| S139 | Phosphorylation | P32298 (GRK4) | score2 | PhosphoSitePlus | 26134571 | |
| K184 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K195 | Acetylation | score1 | PhosphoSitePlus | |||
| K195 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K211 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K216 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K217 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K227 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S244 | Phosphorylation | score2 | PhosphoSitePlus | 26134571 | ||
| S244 | Phosphorylation | P32298 (GRK4) | score2 | PhosphoSitePlus | 26134571 | |
| S249 | Phosphorylation | score2 | PhosphoSitePlus | 26134571 | ||
| S249 | Phosphorylation | P32298 (GRK4) | score2 | PhosphoSitePlus | 26134571 | |
| T256 | Phosphorylation | score2 | PhosphoSitePlus | 26134571 | ||
| T256 | Phosphorylation | P32298 (GRK4) | score2 | PhosphoSitePlus | 26134571 | |
| C261 | Methylation | score1 | IEDB | 31844290 | ||
| T335 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y409 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S419 | Phosphorylation | score2 | PhosphoSitePlus | 26134571 | ||
| S419 | Phosphorylation | P32298 (GRK4) | score2 | PhosphoSitePlus | 26134571 | |
| T426 | Phosphorylation | score2 | PhosphoSitePlus | 26134571 | ||
| T426 | Phosphorylation | P32298 (GRK4) | score2 | PhosphoSitePlus | 26134571 | |
| S430 | Phosphorylation | score2 | PhosphoSitePlus | 26134571 | ||
| S430 | Phosphorylation | P32298 (GRK4) | score2 | PhosphoSitePlus | 26134571 | |
| S485 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 26134571 | ||
| S485 | Phosphorylation | P32298 (GRK4) | score2 | PhosphoSitePlus | 26134571 | |
| K527 | Acetylation | score1 | PhosphoSitePlus |
P32298 (GRK4) as PTM Enzyme
|
Substrate | Site | Score | Source | PMID |
|---|---|---|---|---|---|
| P30411 (BDKRB2) | S366 | score3 | HPRD PhosphoSitePlus Signor | 11517230 | |
| P30411 (BDKRB2) | S373 | score3 | HPRD PhosphoSitePlus Signor | 11517230 | |
| P30411 (BDKRB2) | S375 | score3 | HPRD PhosphoSitePlus Signor | 11517230 | |
| P32298 (GRK4) | S10 | score2 | PhosphoSitePlus | 26134571 | |
| P32298 (GRK4) | S139 | score2 | PhosphoSitePlus | 26134571 | |
| P32298 (GRK4) | S244 | score2 | PhosphoSitePlus | 26134571 | |
| P32298 (GRK4) | S249 | score2 | PhosphoSitePlus | 26134571 | |
| P32298 (GRK4) | T256 | score2 | PhosphoSitePlus | 26134571 | |
| P32298 (GRK4) | S419 | score2 | PhosphoSitePlus | 26134571 | |
| P32298 (GRK4) | T426 | score2 | PhosphoSitePlus | 26134571 | |
| P32298 (GRK4) | S430 | score2 | PhosphoSitePlus | 26134571 | |
| P32298 (GRK4) | S485 | score2 | PhosphoSitePlus | 26134571 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S139 | F139 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| K184 | N184 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| K217 | R217 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
| K227 | * | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S244 | N244 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ] | |
| T335 | K335 | Biomuta | DOID:3571 / liver cancer [ cosmic ] |
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