Protein Information

Cytoscape View


UniProt AC / UniProt ID P32298 / GRK4_HUMAN
Protein Name G protein-coupled receptor kinase 4
Gene Name Name: GRK4
Synonyms:GPRK2L,GPRK4;
Organism Homo sapiens (Human)

PRO ID PR:P32298
DAG View
PRO Name G protein-coupled receptor kinase 4 (human)
Definition A G protein-coupled receptor kinase 4 that is encoded in the genome of human.
Short Label hGRK4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P32298 (GRK4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22223895
S10 Phosphorylation P32298 (GRK4) PhosphoSitePlus 26134571
K14 Ubiquitination PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus
S139 Phosphorylation P32298 (GRK4) PhosphoSitePlus 26134571
K184 Ubiquitination PhosphoSitePlus
K195 Acetylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
S244 Phosphorylation P32298 (GRK4) PhosphoSitePlus 26134571
S249 Phosphorylation P32298 (GRK4) PhosphoSitePlus 26134571
T256 Phosphorylation P32298 (GRK4) PhosphoSitePlus 26134571
T335 Phosphorylation PhosphoSitePlus
Y409 Phosphorylation PhosphoSitePlus
S419 Phosphorylation P32298 (GRK4) PhosphoSitePlus 26134571
T426 Phosphorylation P32298 (GRK4) PhosphoSitePlus 26134571
S430 Phosphorylation P32298 (GRK4) PhosphoSitePlus 26134571
S485 Phosphorylation P32298 (GRK4) PhosphoSitePlus   RLIMS-P 26134571
K527 Acetylation PhosphoSitePlus


P32298 (GRK4) as PTM Enzyme



Substrate Site Score Source PMID
P30411 (BDKRB2) S366 HPRD   PhosphoSitePlus   Signor 11517230
P30411 (BDKRB2) S373 HPRD   PhosphoSitePlus   Signor 11517230
P30411 (BDKRB2) S375 HPRD   PhosphoSitePlus   Signor 11517230
P32298 (GRK4) S10 PhosphoSitePlus 26134571
P32298 (GRK4) S139 PhosphoSitePlus 26134571
P32298 (GRK4) S244 PhosphoSitePlus 26134571
P32298 (GRK4) S249 PhosphoSitePlus 26134571
P32298 (GRK4) T256 PhosphoSitePlus 26134571
P32298 (GRK4) S419 PhosphoSitePlus 26134571
P32298 (GRK4) T426 PhosphoSitePlus 26134571
P32298 (GRK4) S430 PhosphoSitePlus 26134571
P32298 (GRK4) S485 PhosphoSitePlus 26134571


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K184 N184 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K217 R217 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S244 N244 Biomuta DOID:263 / kidney cancer [ cosmic, tcga ]
S249 C249 Biomuta DOID:2394 / ovarian cancer [ tcga ]
T335 K335 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S419 P419 Biomuta DOID:2531 / hematologic cancer [ tcga ]
S485 * Biomuta DOID:1909 / melanoma [ tcga ]