iPTMnet Report for P31645 (SLC6A4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P31645 / SC6A4_HUMAN
Protein Name Sodium-dependent serotonin transporter
Gene Name Name: SLC6A4
Synonyms:HTT,SERT;
Organism Homo sapiens (Human)

PRO ID PR:P31645
DAG View
PRO Name sodium-dependent serotonin transporter (human)
Definition A sodium-dependent serotonin transporter that is encoded in the genome of human.
Short Label hSLC6A4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P31645 (SLC6A4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S13 Phosphorylation Q9UQM7 (CAMK2A) PhosphoSitePlus 24450286
Y47 Phosphorylation PhosphoSitePlus   UniProt 21992875
S48 Phosphorylation PhosphoSitePlus
T59 Phosphorylation PhosphoSitePlus
S62 Phosphorylation RLIMS-P 20118234
T81 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 20118234
Y142 Phosphorylation PhosphoSitePlus   UniProt 21992875
S149 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 24450286
N208 N-Glycosylation GlyGen   UniProt 27049939
N217 N-Glycosylation GlyGen   UniProt 27049939
T276 Phosphorylation Q13976 (PRKG1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 35258286, 17310063, 27140629, ...17913921
S277 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 24450286
T603 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 24450286
S611 Phosphorylation phospho.ELM   PhosphoSitePlus 19270731
T613 Phosphorylation phospho.ELM   PhosphoSitePlus 19270731
T616 Phosphorylation P28482 (MAPK1) , P45984 (MAPK9) , P27361 (MAPK3) , Q16539 (MAPK14) phospho.ELM   PhosphoSitePlus 19270731, 24450286


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S13 L13 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y47 C47 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S62 F62 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S277 Y277 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]