iPTMnet Report for P31645 (SLC6A4)
Protein Information
| UniProt AC / UniProt ID | P31645 / SC6A4_HUMAN |
| Protein Name | Sodium-dependent serotonin transporter |
| Gene Name | Name: SLC6A4 Synonyms:HTT,SERT; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P31645 |
| PRO Name | sodium-dependent serotonin transporter (human) |
| Definition | A sodium-dependent serotonin transporter that is encoded in the genome of human. |
| Short Label | hSLC6A4 |
| Category | organism-gene |
DAG ViewP31645 (SLC6A4) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S13 | Phosphorylation | score2 | PhosphoSitePlus | 24450286 | ||
| S13 | Phosphorylation | Q9UQM7 (CAMK2A) | score2 | PhosphoSitePlus | 24450286 | |
| Y47 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 21992875 | ||
| S48 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T59 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S62 | Phosphorylation | score0 | RLIMS-P | 20118234 | ||
| T81 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus RLIMS-P | 20118234 | ||
| Y142 | Phosphorylation | score3 | PhosphoSitePlus UniProt | 21992875 | ||
| S149 | Phosphorylation | score2 | PhosphoSitePlus | 24450286 | ||
| S149 | Phosphorylation | P17252 (PRKCA) | score2 | PhosphoSitePlus | 24450286 | |
| N208 | N-Glycosylation | score3 | GlyGen UniProt | 27049939 | ||
| N217 | N-Glycosylation | score3 | GlyGen UniProt | 27049939 | ||
| T276 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 35258286, 17310063, 27140629, ... | ||
| T276 | Phosphorylation | Q13976 (PRKG1) | score4 | PhosphoSitePlus Signor | 17913921, 17310063 | |
| S277 | Phosphorylation | score2 | PhosphoSitePlus | 24450286 | ||
| S277 | Phosphorylation | P17252 (PRKCA) | score2 | PhosphoSitePlus | 24450286 | |
| T603 | Phosphorylation | score2 | PhosphoSitePlus | 24450286 | ||
| T603 | Phosphorylation | P17252 (PRKCA) | score2 | PhosphoSitePlus | 24450286 | |
| S611 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus | 19270731 | ||
| T613 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus | 19270731 | ||
| T616 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus | 19270731, 24450286 | ||
| T616 | Phosphorylation | P27361 (MAPK3) | score2 | PhosphoSitePlus | 24450286 | |
| T616 | Phosphorylation | P28482 (MAPK1) | score2 | PhosphoSitePlus | 24450286 | |
| T616 | Phosphorylation | P45984 (MAPK9) | score2 | PhosphoSitePlus | 24450286 | |
| T616 | Phosphorylation | Q16539 (MAPK14) | score2 | PhosphoSitePlus | 24450286 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S13 | L13 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
| Y47 | C47 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| S62 | F62 | Biomuta | [ cosmic ] DOID:1115 / sarcoma [ icgc ] | |
| S277 | Y277 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] |
