iPTMnet Report for P31431 (SDC4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P31431 / SDC4_HUMAN
Protein Name Syndecan-4 precursor
Gene Name Name: SDC4
Organism Homo sapiens (Human)

PRO ID PR:P31431
DAG View
PRO Name syndecan-4 (human)
Definition A syndecan-4 that is encoded in the genome of human.
Short Label hSDC4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P31431 (SDC4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T24 O-Glycosylation GlyGen 30459171
S95 O-Glycosylation GlyGen   UniProt 36213313, 32337544
S97 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 30459171, 25813380
T101 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
K104 Ubiquitination PhosphoSitePlus
S117 O-Glycosylation PhosphoSitePlus
S126 O-Glycosylation PhosphoSitePlus
T134 Phosphorylation PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
S179 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 25260916, 12377772, 32404004
Y180 Phosphorylation P12931 (SRC) PhosphoSitePlus   RLIMS-P 23453597
K190 Ubiquitination PhosphoSitePlus
T193 Phosphorylation PhosphoSitePlus
Y197 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
Site PTM Type PTM Enzyme Score Source PMID
S179 Phosphorylation P17252 (PRKCA) , Q05655 (PRKCD) HPRD 9556568, 11916978
Y197 Phosphorylation HPRD 17016520, 18083107, 17389395


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P31431 (SDC4) Y180 O00560 (SDCBP) increased_association eFIP 23453597


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S95 Y95 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S117 P117 Biomuta [ cosmic ]
S179 G179 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]